ChemInform Abstract: Molecular Design and Chemical Synthesis of Potent Enediynes. Part 2. Dynemicin Model Systems Equipped with C-3 Triggering Devices and Evidence for Quinone Methide Formation in the Mechanism of Action of Dynemicin A.

ChemInform ◽  
2010 ◽  
Vol 24 (9) ◽  
pp. no-no
Author(s):  
K. C. NICOLAOU ◽  
W.-M. DAI
Keyword(s):  
Chemical Synthesis ◽  
Mechanism Of Action ◽  
Molecular Design ◽  
Model Systems ◽  
Quinone Methide

Molecular design and chemical synthesis of potent enediynes. 1. Dynemicin model systems equipped with N-tethered triggering devices

1992 ◽  
Vol 114 (23) ◽  
pp. 8890-8907 ◽  
Author(s):  
K. C. Nicolaou ◽  
P. Maligres ◽  
T. Suzuki ◽  
S. V. Wendeborn ◽  
W. M. Dai ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Molecular Design ◽  
Model Systems

ChemInform Abstract: Molecular Design and Chemical Synthesis of Potent Enediynes. Part 1. Dynemicin Model Systems Equipped with N-Tethered Triggering Devices.

ChemInform ◽  
2010 ◽  
Vol 24 (9) ◽  
pp. no-no
Author(s):  
K. C. NICOLAOU ◽  
P. MALIGRES ◽  
T. SUZUKI ◽  
S. V. WENDEBORN ◽  
W.-M. DAI ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Molecular Design ◽  
Model Systems

Designer drugs: pipe-dreams or realities?

Parasitology ◽  
1997 ◽  
Vol 114 (7) ◽  
pp. 145-151 ◽  
Author(s):  
W. E. GUTTERIDGE
Keyword(s):  
Chemical Synthesis ◽  
Rational Design ◽  
Molecular Design ◽  
Designer Drugs ◽  
Rational Approach ◽  
Parasitic Infections ◽  
Tropical Diseases ◽  
Track Record ◽  
Discovery Research ◽  
Long Run

New chemotherapies are urgently needed for the parasitic infections of animals and for the tropical diseases of man. Rational molecular design approaches to attempt to discover such products require a massive investment of resources up-front of actual chemical synthesis. However, such investment is justified, since chemical synthesis itself is highly resource-consuming. The fact that few targets have yet been validated to justify a rational approach is an argument only to get on and validate more. Not all the components of molecular design can yet be done totally rationally, but this is not an argument against applying this approach where it is possible. Absence of a successful track record is inevitable for any newly emerging technology. It is too early to draw conclusions about the relative costs of rational design versus empirical synthesis, since the former is only now beginning to become reality and the latter is in the middle of a (combinatorial) revolution. Similarly, it is too soon to predict with certainty which of these two approaches will prevail in the long run. However, they lend themselves to parallel tracks, so both may well continue for the foreseeable future. Current concerns about who would develop successful discoveries are not reasons for stopping discovery research. Indeed, a string of putative products held at the discovery/development interface would be useful ammunition to those trying to develop partnerships such as a Tropical Diseases R&D Alliance aimed at carrying out such work and sharing costs.

scholarly journals Molecular design of a eukaryotic messenger RNA and its chemical synthesis

1992 ◽  
Vol 20 (7) ◽  
pp. 1643-1648 ◽  
Author(s):  
Reiko Iwase ◽  
Masayuki Maeda ◽  
Toshiki Fujiwara ◽  
Mitsuo Sekine ◽  
Tsujiaki Hata ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Messenger Rna ◽  
Molecular Design

ChemInform Abstract: Novel Dienediyne Systems Related to the Neocarzinostatin Chromophore: Molecular Design, Chemical Synthesis, and Evaluation.

ChemInform ◽  
2010 ◽  
Vol 27 (11) ◽  
pp. no-no
Author(s):  
K. TOSHIMA ◽  
K. OHTA ◽  
K. YANAGAWA ◽  
T. KANO ◽  
M. NAKATA ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Molecular Design

Novel designed enediynes: Molecular design, chemical synthesis, mode of cycloaromatization and guanine-specific DNA cleavage

1996 ◽  
Vol 4 (1) ◽  
pp. 105-113 ◽  
Author(s):  
Kazunobu Toshima ◽  
Kazumi Ohta ◽  
Takaaki Kano ◽  
Takatsugu Nakamura ◽  
Masaya Nakata ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Dna Cleavage ◽  
Molecular Design

scholarly journals Interaction of Viscotoxins A3 and B with Membrane Model Systems: Implications to Their Mechanism of Action

2003 ◽  
Vol 85 (2) ◽  
pp. 971-981 ◽  
Author(s):  
Marcela Giudici ◽  
Roberto Pascual ◽  
Laura de la Canal ◽  
Karola Pfüller ◽  
Uwe Pfüller ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Model Systems ◽  
Membrane Model

Molecular design, chemical synthesis, and biological action of enediynes

1992 ◽  
Vol 25 (11) ◽  
pp. 497-503 ◽  
Author(s):  
Kyriacos C. Nicolaou ◽  
Adrian L. Smith
Keyword(s):  
Chemical Synthesis ◽  
Molecular Design ◽  
Biological Action
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