Molecular design, chemical synthesis, and biological action of enediynes

1992 ◽  
Vol 25 (11) ◽  
pp. 497-503 ◽  
Author(s):  
Kyriacos C. Nicolaou ◽  
Adrian L. Smith
Keyword(s):  
Chemical Synthesis ◽  
Molecular Design ◽  
Biological Action

Designer drugs: pipe-dreams or realities?

Parasitology ◽  
1997 ◽  
Vol 114 (7) ◽  
pp. 145-151 ◽  
Author(s):  
W. E. GUTTERIDGE
Keyword(s):  
Chemical Synthesis ◽  
Rational Design ◽  
Molecular Design ◽  
Designer Drugs ◽  
Rational Approach ◽  
Parasitic Infections ◽  
Tropical Diseases ◽  
Track Record ◽  
Discovery Research ◽  
Long Run

New chemotherapies are urgently needed for the parasitic infections of animals and for the tropical diseases of man. Rational molecular design approaches to attempt to discover such products require a massive investment of resources up-front of actual chemical synthesis. However, such investment is justified, since chemical synthesis itself is highly resource-consuming. The fact that few targets have yet been validated to justify a rational approach is an argument only to get on and validate more. Not all the components of molecular design can yet be done totally rationally, but this is not an argument against applying this approach where it is possible. Absence of a successful track record is inevitable for any newly emerging technology. It is too early to draw conclusions about the relative costs of rational design versus empirical synthesis, since the former is only now beginning to become reality and the latter is in the middle of a (combinatorial) revolution. Similarly, it is too soon to predict with certainty which of these two approaches will prevail in the long run. However, they lend themselves to parallel tracks, so both may well continue for the foreseeable future. Current concerns about who would develop successful discoveries are not reasons for stopping discovery research. Indeed, a string of putative products held at the discovery/development interface would be useful ammunition to those trying to develop partnerships such as a Tropical Diseases R&D Alliance aimed at carrying out such work and sharing costs.

scholarly journals Molecular design of a eukaryotic messenger RNA and its chemical synthesis

1992 ◽  
Vol 20 (7) ◽  
pp. 1643-1648 ◽  
Author(s):  
Reiko Iwase ◽  
Masayuki Maeda ◽  
Toshiki Fujiwara ◽  
Mitsuo Sekine ◽  
Tsujiaki Hata ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Messenger Rna ◽  
Molecular Design

ChemInform Abstract: Novel Dienediyne Systems Related to the Neocarzinostatin Chromophore: Molecular Design, Chemical Synthesis, and Evaluation.

ChemInform ◽  
2010 ◽  
Vol 27 (11) ◽  
pp. no-no
Author(s):  
K. TOSHIMA ◽  
K. OHTA ◽  
K. YANAGAWA ◽  
T. KANO ◽  
M. NAKATA ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Molecular Design

Molecular design and chemical synthesis of potent enediynes. 1. Dynemicin model systems equipped with N-tethered triggering devices

1992 ◽  
Vol 114 (23) ◽  
pp. 8890-8907 ◽  
Author(s):  
K. C. Nicolaou ◽  
P. Maligres ◽  
T. Suzuki ◽  
S. V. Wendeborn ◽  
W. M. Dai ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Molecular Design ◽  
Model Systems

RADIATION, THE CELLULAR APPROACH

1960 ◽  
Vol 38 (3) ◽  
pp. 320-325
Author(s):  
Gordon M. Clark ◽  
Donald G. Baker
Keyword(s):  
Cell Division ◽  
Chemical Synthesis ◽  
Dose Rate ◽  
Current Trend ◽  
Biological Action ◽  
Cellular Level ◽  
Chromosome Breaks ◽  
Effect Of Oxygen ◽  
Almost All ◽  
Dose Rate Effect

The basic biological action of radiation must initially involve particular cells. The sensitivity of various cells differs but some of the differences may be due to a dose-rate effect. When cells are irradiated with doses in the lethal range, inhibition of cell division occurs. A notable feature of mitotic inhibition is that it depends not only on dose but on dose rate. Chromosome breaks produced in cells may be a visible manifestation of an interruption in chemical synthesis produced by the passage of ionizing particles. The effect of oxygen is apparently of primary importance in biological changes produced by irradiation. Almost all are decreased in its absence. The current trend in research on the cellular level is towards determining the more obscure injuries which cannot be seen under the microscope.

Novel designed enediynes: Molecular design, chemical synthesis, mode of cycloaromatization and guanine-specific DNA cleavage

1996 ◽  
Vol 4 (1) ◽  
pp. 105-113 ◽  
Author(s):  
Kazunobu Toshima ◽  
Kazumi Ohta ◽  
Takaaki Kano ◽  
Takatsugu Nakamura ◽  
Masaya Nakata ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Dna Cleavage ◽  
Molecular Design

Novel Dienediyne Systems Related to the Neocarzinostatin Chromophore: Molecular Design, Chemical Synthesis, and Evaluation

1995 ◽  
Vol 117 (44) ◽  
pp. 10825-10831 ◽  
Author(s):  
Kazunobu Toshima ◽  
Kazumi Ohta ◽  
Koji Yanagawa ◽  
Takaaki Kano ◽  
Masaya Nakata ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Molecular Design
Sign in / Sign up

Export Citation Format

Share Document