ChemInform Abstract: Reaction of Sulfoxides with Nitriles in Presence of Trifluor-acetic Anhydride and Trifluoroacetic Acid: A Case of Ritter Reaction on Pummerer Intermediate.

1985 ◽  
Vol 16 (49) ◽  
Author(s):  
Y. D. VANKAR ◽  
C. T. RAO
Keyword(s):  
Acetic Anhydride ◽  
Trifluoroacetic Acid ◽  
Ritter Reaction

Base-catalyzed Degradations of Carbohydrates. III. Formation of a Novel Perester from 1-O-Acetyl-3-deoxy-2,4,6-tri-O-methyl-α-D-erytho-hex-2-enopyranose

1973 ◽  
Vol 51 (3) ◽  
pp. 388-393 ◽  
Author(s):  
G. O. Aspinall ◽  
R. R. King ◽  
Zofia Pawlak
Keyword(s):  
Acetic Anhydride ◽  
Spectral Data ◽  
Trifluoroacetic Acid ◽  
Oxidative Degradation ◽  
Chemical Degradation ◽  
Reductive Decomposition

1-O-Acetyl-3-deoxy-2,4,6-tri-O-methyl-α-D-erythro-hex-2-enopyranose (1) reacts with m-chloroperbenzoic acid to give a novel perester, which has been assigned the structure 1,2-O-(1′-m-chloroperbenzoyl-oxyethylidene)-2-methoxy-4,6-di-O-methyl-α-D-glucopyranose (2), on the basis of spectral data and chemical degradation. The perester 2 and the derived acetate 3 undergo oxidative degradation on treatment with trifluoroacetic acid to give 3,5-di-O-methyl- (4) and 2-O-acetyl-3,5-di-O-methyl-D-arabinonolactone (5), respectively. Reductive decomposition of the acetylated perester 3 yields 1,3-di-O-acetyl-4,6-di-O-methyl-α-D-arabino-hexopyranosulose (6), which, on treatment with acetic anhydride in pyridine, gives successively 1,2,3-tri-O-acetyl-4,6-di-O-methyl-α-D-erythro-hex-2-enopyranose (7), 2-O-acetyl-1-deoxy-4,6-di-O-methyl-α-D-erythro-hex-1-enopyranose-3-ulose (8), and 5-acetoxy-2-(methoxy-methyl)-4H-pyran-4-one (9).

Reaction of 1,6-anhydro-4-O-benzyl-2-deoxy-2-isothiocyanato-β-D-glucopyranose; Preparation of 2-amino-1,6-anhydro-2,3-dideoxy-2,3-dideoxy-β-D-ribo-hexopyranose

1985 ◽  
Vol 50 (9) ◽  
pp. 2000-2009 ◽  
Author(s):  
Tomáš Elbert ◽  
Miloslav Černý
Keyword(s):  
Acetic Anhydride ◽  
Raney Nickel ◽  
Carbon Disulfide ◽  
Trifluoroacetic Acid

1,6-Anhydro-4-O-benzyl-2-deoxy-2-isothiocyanato-β-D-glucopyranose (IV), prepared from 2-amino-1,6-anhydro-4-O-benzyl-2-deoxy-β-D-glucopyranose (I) by reaction with carbon disulfide followed by oxidation with iodine, was converted into the 3-O-p-toluenesulfonate VII. This was cyclized to give either the 2,3-epimino derivative X or the thiazoline XII. 2-Acetamido-3-S-acetyl-1,6-anhydro-4-O-benzyl-2-deoxy-3-thio-β-D-glucopyranose (XVI), obtained from compound XII, was desulfurized with Raney nickel to afford 2-acetamido-1,6-anhydro-2,3-dideoxy-β-D-ribo-hexopyranose (XVII). The isothiocyanato group was not affected upon acetylation of compound IV and acetolysis of the 1,6-anhydride bond with acetic anhydride and trifluoroacetic acid.

Cyclization of cysteinylglycine sulfoxides under Pummerer reaction conditions

1979 ◽  
Vol 57 (18) ◽  
pp. 2412-2425 ◽  
Author(s):  
Saul Wolfe ◽  
Peter Michael Kazmaier ◽  
Hillar Auksi
Keyword(s):  
Acetic Anhydride ◽  
Trifluoroacetic Acid ◽  
Carboxyl Group ◽  
Reaction Conditions ◽  
Pummerer Reaction ◽  
Peptide Cyclization

A number of sulfoxides derived from 3-benzylthiopropionic acid, S-benzylcysteine, and S-phenylcystelne have been synthesized and exposed to typical Pummerer reaction conditions. Cyclization of the S-benzyl sulfoxides to six-membered or seven-membered heterocyclic rings (1,3-thiazin-4-ones and 1,3,6-oxathiazepines) is observed only in acetic anhydride solvent and only after conversion of the carboxyl group to an amide or peptide. Cyclization of S-phenylcysteinyl amides to β-lactams could not be achieved. The thiazolidine isomers of the six- and seven-membered rings have been synthesized and found not to be intermediates in the acetic anhydride reactions. The thiazolidines do rearrange to the six- and (or) seven-membered rings in anhydrous trifluoroacetic acid solvent. S-Benzylphthalimidocysteinylglycine sulfoxide, a 3:2 mixture of epimers at sulfur, affords a 3:2 mixture of isomeric thiazinones. A mechanism for these cyclizations is proposed, and it is suggested that the configuration at sulfur controls the configuration at the new asymmetric centre in the product.

Zn(ClO 4 ) 2 ⋅6H 2 O‐Catalyzed One‐Pot Synthesis of Amides via Ritter Reaction with Alcohols, Acetic Anhydride and Nitriles

2018 ◽  
Vol 3 (42) ◽  
pp. 11775-11778 ◽  
Author(s):  
Chengliang Feng ◽  
Bin Yan ◽  
Wenjin Yao ◽  
Junqing Chen ◽  
Min Ji
Keyword(s):  
Acetic Anhydride ◽  
Ritter Reaction ◽  
One Pot ◽  
One Pot Synthesis
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