ChemInform Abstract: SUBSTITUTED ACRYLONITRILES IN HETEROCYCLIC SYNTHESIS. THE REACTION OF α-SUBSTITUTED β-(2-FURYL)ACRYLONITRILES WITH SOME ACTIVE METHYLENE HETEROCYCLES

1985 ◽  
Vol 16 (38) ◽  
Author(s):  
F. M. ABDELRAZEK ◽  
Z. E.-S. KANDEEL ◽  
K. M. H. HIMLY ◽  
M. H. ELNAGDI
Keyword(s):  
Heterocyclic Synthesis ◽  
Active Methylene

Nitriles in Heterocyclic Synthesis: A New Synthesis of Some 4H-Naphthopyrans, 2H-Benzothiopyrans and Their Fused Derivatives

1992 ◽  
Vol 57 (7) ◽  
pp. 1570-1574 ◽  
Author(s):  
Abdel-Fattah A. Harb ◽  
Awatef M. El-Maghraby ◽  
Saoud A. Metwally
Keyword(s):  
Heterocyclic Synthesis ◽  
New Synthesis ◽  
Active Methylene

α,β-Unsaturated nitriles are versatile reagents and their chemistry has received considerable attention. The reactivity of cinnamonitriles I toward active methylene reagents has been extensively utilised for synthesis of pyranes.

Pyrazolo[3,4-b]pyridine in heterocyclic synthesis: synthesis of new pyrazolo[3,4-b]pyridines, imidazo[1',2':1,5]pyrazolo[3,4-b]pyridines, and pyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidines

2007 ◽  
Vol 85 (9) ◽  
pp. 592-599 ◽  
Author(s):  
Mohamed A.M Gad-Elkareem ◽  
Azza M Abdel-Fattah ◽  
Mohamed A.A Elneairy
Keyword(s):  
Pyridine Derivative ◽  
Pyridine Derivatives ◽  
Heterocyclic Synthesis ◽  
Acetyl Acetone ◽  
Active Methylene

Pyrazolo[3,4-b]pyridine derivatives 7 and 9 were synthesized via the reaction of 3-amino-1H-pyrazolo-[3,4-b]pyridine derivative 2 with ω-bromoacetophenones. Reaction of 7 and 9 with Ac2O afforded the imidazo[1',2':1,5]py razolo[3,4-b]pyridine derivative 8 and pyrazolo[3,4-b]pyridine derivative 10, respectively. Reaction of 2 with chloroacetonitrile followed by DMF-DMA gave imidazo[1',2':1,5]pyrazolo[3,4-b]pyridines 4 and 5, respectively. Acetyl acetone and 1,1-dicyano-2,2-dimethylthioethene were reacted with 2 to afford the pyrido[2',3':3,4]pyrazolo-[1,5-a]-pyrimidines 11 and 14, respectively. Also, 2 reacted with DMF-DMA to yield the formamidine 15, which in turn, reacted with active methylene reagents, yielding the corresponding pyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidines 18 and 23a-23d.Key words: 1H-pyrazolo[3,4-b]pyridines, imidazo[1',2':1,5]pyrazolo[3,4-b]pyridines, pyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidines.

Substituted Acrylonitriles in Heterocyclic Synthesis. The Reaction of α-Substituted β-(2-Furyl)-acrylonitriles with Some Active-Methylene Heterocycles

Synthesis ◽  
1985 ◽  
Vol 1985 (04) ◽  
pp. 432-434 ◽  
Author(s):  
Fathy Mohamed Abdelrazek ◽  
Zaghloul El-Shahat Kandeel ◽  
Khalid Mohamed Hassan Himly ◽  
Mohamed Hilmy Elnagdi
Keyword(s):  
Heterocyclic Synthesis ◽  
Active Methylene

Activated Nitriles in Heterocyclic Syntheses, I Novel Synthesis of Pyrrolones and 1,2,4-Triazol-3-oyl nitriles

1983 ◽  
Vol 38 (6) ◽  
pp. 764-768 ◽  
Author(s):  
Mohamed Rifaat Hamza Elmoghayar ◽  
Mohamed Kamal Ahmed Ibrahim ◽  
Mahmoud Mohamed Mahfouz Ramiz ◽  
Mohamed Hilmy Elnagdi
Keyword(s):  
Heterocyclic Synthesis ◽  
Novel Synthesis ◽  
Active Methylene

Abstract Heterocyclic Synthesis, Pyrrolones The behaviour of 4-benzylidene-2-oxazolin-5-one (2) and of 4-phenylazo-2-oxazolin-5-one (3) toward a variety of active methylene reagents is reported. Cleavage of the oxazolin-5-one ring was observed in most cases. A variety of new, otherwise, difficult accessible, azolyl derivatives could be prepared.

Activated nitriles in heterocyclic synthesis. The reaction of cinnamonitrile derivatives with active methylene reagents

1984 ◽  
Vol 21 (5) ◽  
pp. 1261-1264 ◽  
Author(s):  
Nosrat Mustafa Abed ◽  
Ebtisam Abdel Aziz Hafez ◽  
Ibraheim Elsakka ◽  
Mohamed Hilmy Elnagdi
Keyword(s):  
Heterocyclic Synthesis ◽  
Active Methylene

The Uses of Ethyl Cyanobromoacetate in Heterocyclic Synthesis: Novel Synthesis of Thiophene, Pyrazolo[3,4d]thiazole and Thieno[2,3d]pyridazine Derivatives

1992 ◽  
Vol 57 (8) ◽  
pp. 1747-1757 ◽  
Author(s):  
Rafat Milad Mohareb ◽  
Salah El-Kousy ◽  
Abdel Monem El-Torgoman
Keyword(s):  
Phenyl Isothiocyanate ◽  
Heterocyclic Synthesis ◽  
Novel Synthesis ◽  
Pyridazine Derivatives ◽  
Active Methylene ◽  
Dimethylformamide Solution

The reaction of active methylene reagents Ia-Ie with phenyl isothiocyanate in basic N,N-dimethylformamide solution followed by cyclization with ethyl cyanobromoacetate II affords the acyclic thioether derivatives IVa-IVe. The use of IVa-IVe in heterocyclic synthesis was described.

Nitriles in Heterocyclic Synthesis: The Reaction of 2-Thiocarbamoyl Cinnamonitriles with Active Methylene Reagents

1987 ◽  
Vol 42 (1) ◽  
pp. 107-112 ◽  
Author(s):  
Abdel Moneim El-Torgoman ◽  
Salah Mohamed El-Kousy ◽  
Zaghloul El-Shahat Kandeel
Keyword(s):  
Heterocyclic Synthesis ◽  
Active Methylene

Abstract Substituted pyridin-2-thiones, 2-pyridones, thiopyrans and pyranoazoles could be synthesized via the reaction of 2-thiocarbamoyl cinnamonitriles with some active methylene reagents.

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