The Uses of Ethyl Cyanobromoacetate in Heterocyclic Synthesis: Novel Synthesis of Thiophene, Pyrazolo[3,4d]thiazole and Thieno[2,3d]pyridazine Derivatives

Rafat Milad Mohareb; Salah El-Kousy; Abdel Monem El-Torgoman

doi:10.1135/cccc19921747

The Uses of Ethyl Cyanobromoacetate in Heterocyclic Synthesis: Novel Synthesis of Thiophene, Pyrazolo[3,4d]thiazole and Thieno[2,3d]pyridazine Derivatives

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19921747 ◽

1992 ◽

Vol 57 (8) ◽

pp. 1747-1757 ◽

Cited By ~ 10

Author(s):

Rafat Milad Mohareb ◽

Salah El-Kousy ◽

Abdel Monem El-Torgoman

Keyword(s):

Phenyl Isothiocyanate ◽

Heterocyclic Synthesis ◽

Novel Synthesis ◽

Pyridazine Derivatives ◽

Active Methylene ◽

Dimethylformamide Solution

The reaction of active methylene reagents Ia-Ie with phenyl isothiocyanate in basic N,N-dimethylformamide solution followed by cyclization with ethyl cyanobromoacetate II affords the acyclic thioether derivatives IVa-IVe. The use of IVa-IVe in heterocyclic synthesis was described.

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ChemInform Abstract: Phenyl Isothiocyanate in Heterocyclic Synthesis: Novel Synthesis of Thiazoles, Thieno(2,3-b)pyridine, Thiophene and Thieno(3,2-c)pyridazine Derivatives.

ChemInform ◽

10.1002/chin.199243160 ◽

2010 ◽

Vol 23 (43) ◽

pp. no-no

Author(s):

R. M. MOHAREB

Keyword(s):

Phenyl Isothiocyanate ◽

Heterocyclic Synthesis ◽

Novel Synthesis ◽

Pyridazine Derivatives

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Phenyl isothiocyanate in heterocyclic synthesis: Novel synthesis of thiazoles, thieno[2,3-b]pyridine, thiophene and thieno[3,2-c]pyridazine derivatives

Monatshefte für Chemie - Chemical Monthly ◽

10.1007/bf00810946 ◽

1992 ◽

Vol 123 (4) ◽

pp. 341-347 ◽

Cited By ~ 18

Author(s):

Rafat Milad Mohareb

Keyword(s):

Phenyl Isothiocyanate ◽

Heterocyclic Synthesis ◽

Novel Synthesis ◽

Pyridazine Derivatives

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ChemInform Abstract: Activated Nitriles in Heterocyclic Synthesis: A Novel Synthesis of Pyridine and Pyridazine Derivatives.

Chemischer Informationsdienst ◽

10.1002/chin.198617243 ◽

1986 ◽

Vol 17 (17) ◽

Author(s):

S. M. FAHMY ◽

R. M. MOHAREB

Keyword(s):

Heterocyclic Synthesis ◽

Novel Synthesis ◽

Pyridazine Derivatives

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ChemInform Abstract: Uses of Ethyl Cyanobromoacetate in Heterocyclic Synthesis: Novel Synthesis of Thiophene, Pyrazolo(3,4-d)thiazole and Thieno(2,3-d)pyridazine Derivatives.

ChemInform ◽

10.1002/chin.199252083 ◽

2010 ◽

Vol 23 (52) ◽

pp. no-no

Author(s):

R. M. MOHAREB ◽

S. EL-KOUSY ◽

A. M. EL-TORGOMAN

Keyword(s):

Heterocyclic Synthesis ◽

Novel Synthesis ◽

Pyridazine Derivatives

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Nitriles in Heterocyclic Synthesis: Novel Synthesis of Pyridazine Derivatives

Heterocycles ◽

10.3987/r-1986-05-1219 ◽

1986 ◽

Vol 24 (5) ◽

pp. 1219 ◽

Cited By ~ 16

Author(s):

Nadia S. Ibrahim ◽

Fathy M. Abdel Galil ◽

Ramadan M. Abdel-Motaleb ◽

Mohamed H. Elnagdi

Keyword(s):

Heterocyclic Synthesis ◽

Novel Synthesis ◽

Pyridazine Derivatives

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ChemInform Abstract: The Reaction of Active Methylene Reagents with Sulfur and Phenyl Isothiocyanate: Novel Synthesis of Thiazole, Thiazolo(4,5-d)pyrimidine and 4,5′-Bithiazolyl Derivatives.

ChemInform ◽

10.1002/chin.199434158 ◽

2010 ◽

Vol 25 (34) ◽

pp. no-no

Author(s):

R. M. MOHAREB ◽

W. W. WARDAKHAN ◽

F. Z. EL-ABLACK

Keyword(s):

Phenyl Isothiocyanate ◽

Novel Synthesis ◽

Active Methylene

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Activated Nitriles in Heterocyclic Syntheses, I Novel Synthesis of Pyrrolones and 1,2,4-Triazol-3-oyl nitriles

Zeitschrift für Naturforschung B ◽

10.1515/znb-1983-0619 ◽

1983 ◽

Vol 38 (6) ◽

pp. 764-768 ◽

Cited By ~ 4

Author(s):

Mohamed Rifaat Hamza Elmoghayar ◽

Mohamed Kamal Ahmed Ibrahim ◽

Mahmoud Mohamed Mahfouz Ramiz ◽

Mohamed Hilmy Elnagdi

Keyword(s):

Heterocyclic Synthesis ◽

Novel Synthesis ◽

Active Methylene

Abstract Heterocyclic Synthesis, Pyrrolones The behaviour of 4-benzylidene-2-oxazolin-5-one (2) and of 4-phenylazo-2-oxazolin-5-one (3) toward a variety of active methylene reagents is reported. Cleavage of the oxazolin-5-one ring was observed in most cases. A variety of new, otherwise, difficult accessible, azolyl derivatives could be prepared.

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