ChemInform Abstract: HETEROCYCLIC COMPOUNDS WITH BRIDGEHEAD NITROGEN ATOMS. PART 9. SYNTHESIS IN THE PYRROLO(2,1,5-DE)QUINOLIZINE ((2.3.3)CYCLAZINE) SERIES STARTING FROM INDOLIZINES

1982 ◽  
Vol 13 (10) ◽  
Author(s):  
J. W. DICK ◽  
W. K. GIBSON ◽  
D. LEAVER ◽  
J. E. ROFF
Keyword(s):  
Heterocyclic Compounds ◽  
Bridgehead Nitrogen

Heterocyclic compounds with a bridgehead nitrogen atom. Synthesis in the imidazo[1,2-c]quinazoline series

1990 ◽  
Vol 27 (2) ◽  
pp. 421-425 ◽  
Author(s):  
A. Gueiffier ◽  
H. Viols ◽  
J. P. Chapat ◽  
O. Chavignon ◽  
J. C. Teulade ◽  
...  
Keyword(s):  
Nitrogen Atom ◽  
Heterocyclic Compounds ◽  
Bridgehead Nitrogen

scholarly journals Synthesis and DFT Study of Newly Schiff Base and Fused Heterocyclic Compounds as Antibacterial Agent

2019 ◽  
Vol 16 ◽  
pp. 5395-5403
Author(s):  
Sameh Rizk ◽  
Ismail M. Awheda ◽  
Fathi A. Smida
Keyword(s):  
Schiff Base ◽  
Antibacterial Agent ◽  
Heterocyclic Compounds ◽  
Excellent Result ◽  
Antimicrobial Activities ◽  
Rate Of Reaction ◽  
Bacteria And Fungi ◽  
Bridgehead Nitrogen ◽  
Nitrogen Nucleophiles ◽  
New Compounds

Treatment of 2,3-di-(4-chlorophenyl) oxirane-2,3-dicarbonitriles(1) with nitrogen nucleophiles, e.g. N2H4, NH2OH afforded pyrazole 2, 1.2oxazole 3 derivatives respectively The 3-amino pyrazole-4-one derivatives 2 can be used as a key starting materials to synthesize some important Schiff base 4 and fused heterocyclic compounds e.g. Imidazolo-[4,5-c]pyrazole 5, Pyrazolo[3,4-e]1,2,4-triazine 6, pyrazol[1,2-a] 1,3,5-triazine 7, 8 and 9. The electromeric effect of the halogen atom in the aryl moieties can be controlled upon the rate of reaction and the yield of the product. The structures of synthesized new compounds were characterized by spectral data and screened for their antimicrobial activities against various bacteria and fungi strains. The heterocyclic compounds 7, 8 and 9 that contained bridgehead nitrogen gave an excellent result. 

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