ChemInform Abstract: HETEROCYCLIC COMPOUNDS WITH BRIDGEHEAD NITROGEN ATOMS. PART 6. SYNTHESIS OF PYRAZINO(2,1,6-CD,5,4,3-C′D′)DIINDOLIZINES AND AN EXAMPLE OF THE 4H-QUINOLIZINE-1-(2-PYRIDYL)BUTADIENE TAUTOMERIC SYSTEM

G. G. ABBOT; D. LEAVER; K. C. MATHUR

doi:10.1002/chin.197842255

ChemInform Abstract: HETEROCYCLIC COMPOUNDS WITH BRIDGEHEAD NITROGEN ATOMS. PART 6. SYNTHESIS OF PYRAZINO(2,1,6-CD,5,4,3-C′D′)DIINDOLIZINES AND AN EXAMPLE OF THE 4H-QUINOLIZINE-1-(2-PYRIDYL)BUTADIENE TAUTOMERIC SYSTEM

Chemischer Informationsdienst ◽

10.1002/chin.197842255 ◽

1978 ◽

Vol 9 (42) ◽

Author(s):

G. G. ABBOT ◽

D. LEAVER ◽

K. C. MATHUR

Keyword(s):

Heterocyclic Compounds ◽

Bridgehead Nitrogen

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Synthesis of some New 3-Substituted Heterocyclic Compounds Containing Bridgehead Nitrogen from 2-Amino Pyridine with Study Their Biological Activity

Journal of Al-Nahrain University-Science ◽

10.22401/anjs.00.1.04 ◽

2018 ◽

Vol 00 (1) ◽

pp. 26-36

Author(s):

Naeemah Al-Lami ◽

◽

Ahmad Shaker Mahmoud ◽

Keyword(s):

Biological Activity ◽

Heterocyclic Compounds ◽

Bridgehead Nitrogen

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Reactivity of cyclopalladated compounds. 28. Alkyne reactions with the cyclopalladated 8-methylquinoline ligand. Synthesis of novel heterocyclic compounds with a bridgehead nitrogen

The Journal of Organic Chemistry ◽

10.1021/jo00033a042 ◽

1992 ◽

Vol 57 (7) ◽

pp. 2147-2154 ◽

Cited By ~ 26

Author(s):

Michel Pfeffer ◽

Marc A. Rotteveel ◽

Guy Le Borgne ◽

Jean Fischer

Keyword(s):

Heterocyclic Compounds ◽

Ligand Synthesis ◽

Cyclopalladated Compounds ◽

Bridgehead Nitrogen

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Heterocyclic compounds with a bridgehead nitrogen atom. Synthesis in the imidazo[1,2-c]quinazoline series

Journal of Heterocyclic Chemistry ◽

10.1002/jhet.5570270259 ◽

1990 ◽

Vol 27 (2) ◽

pp. 421-425 ◽

Cited By ~ 7

Author(s):

A. Gueiffier ◽

H. Viols ◽

J. P. Chapat ◽

O. Chavignon ◽

J. C. Teulade ◽

...

Keyword(s):

Nitrogen Atom ◽

Heterocyclic Compounds ◽

Bridgehead Nitrogen

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ChemInform Abstract: HETEROCYCLIC COMPOUNDS WITH BRIDGEHEAD NITROGEN ATOMS. PART 8. THE SYNTHESIS AND PROPERTIES OF CYCLOPENTA(4,5)AZEPINO(7,1,2-CD)PYRROLIZINE (CYCLOPENTA(H)(2.2.4)CYCLAZINE)

Chemischer Informationsdienst ◽

10.1002/chin.198035259 ◽

1980 ◽

Vol 11 (35) ◽

Author(s):

M. A. JESSEP ◽

D. LEAVER

Keyword(s):

Heterocyclic Compounds ◽

Bridgehead Nitrogen

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ChemInform Abstract: STUDIES ON HETEROCYCLIC COMPOUNDS. PART-VI: SYNTHESIS OF BRIDGEHEAD NITROGEN TRIAZINE AND PYRIMIDINE HETEROCYCLES

Chemischer Informationsdienst ◽

10.1002/chin.198404206 ◽

1984 ◽

Vol 15 (4) ◽

Author(s):

S. N. DEHURI ◽

P. C. PRADHAN ◽

A. NAYAK

Keyword(s):

Heterocyclic Compounds ◽

Bridgehead Nitrogen

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ChemInform Abstract: HETEROCYCLIC COMPOUNDS WITH BRIDGEHEAD NITROGEN ATOMS. PART 9. SYNTHESIS IN THE PYRROLO(2,1,5-DE)QUINOLIZINE ((2.3.3)CYCLAZINE) SERIES STARTING FROM INDOLIZINES

Chemischer Informationsdienst ◽

10.1002/chin.198210237 ◽

1982 ◽

Vol 13 (10) ◽

Author(s):

J. W. DICK ◽

W. K. GIBSON ◽

D. LEAVER ◽

J. E. ROFF

Keyword(s):

Heterocyclic Compounds ◽

Bridgehead Nitrogen

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Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: Design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.02.029 ◽

2014 ◽

Vol 22 (7) ◽

pp. 2052-2059 ◽

Cited By ~ 41

Author(s):

Ye Tian ◽

Deping Du ◽

Diwakar Rai ◽

Liu Wang ◽

Huiqing Liu ◽

...

Keyword(s):

Heterocyclic Compounds ◽

Biological Evaluation ◽

Pyrimidine Derivatives ◽

Design Synthesis ◽

Bridgehead Nitrogen ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Heterocyclic compounds with bridgehead nitrogen atoms. Part 7. The synthesis of pyrrolo[2,1,5-cd]indolizines ([2,2,3]cyclazines) and pyrazino[2,1,6-cd]pyrrolizines (6-aza[2,2,3]cyclazines) from 3H-pyrrolizine

Journal of the Chemical Society Perkin Transactions 1 ◽

10.1039/p19800001319 ◽

1980 ◽

pp. 1319 ◽

Cited By ~ 12

Author(s):

Michael A. Jessep ◽

Derek Leaver

Keyword(s):

Heterocyclic Compounds ◽

Bridgehead Nitrogen

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Heterocyclic compounds with bridgehead nitrogen atoms. Part 10. Synthesis in the pyrrolo[2,1,5-de]quinolizine series ([2.3.3]cyclazinones and [2.3.3]cyclazinylium salts) starting from quinolizines

Journal of the Chemical Society Perkin Transactions 1 ◽

10.1039/p19840002553 ◽

1984 ◽

pp. 2553 ◽

Cited By ~ 10

Author(s):

David Farquhar ◽

Thomas T. Gough ◽

Derek Leaver ◽

James F. Miller ◽

James W. Dick ◽

...

Keyword(s):

Heterocyclic Compounds ◽

Bridgehead Nitrogen

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Synthesis and DFT Study of Newly Schiff Base and Fused Heterocyclic Compounds as Antibacterial Agent

JOURNAL OF ADVANCES IN CHEMISTRY ◽

10.24297/jac.v16i0.8499 ◽

2019 ◽

Vol 16 ◽

pp. 5395-5403

Author(s):

Sameh Rizk ◽

Ismail M. Awheda ◽

Fathi A. Smida

Keyword(s):

Schiff Base ◽

Antibacterial Agent ◽

Heterocyclic Compounds ◽

Excellent Result ◽

Antimicrobial Activities ◽

Rate Of Reaction ◽

Bacteria And Fungi ◽

Bridgehead Nitrogen ◽

Nitrogen Nucleophiles ◽

New Compounds

Treatment of 2,3-di-(4-chlorophenyl) oxirane-2,3-dicarbonitriles(1) with nitrogen nucleophiles, e.g. N2H4, NH2OH afforded pyrazole 2, 1.2oxazole 3 derivatives respectively The 3-amino pyrazole-4-one derivatives 2 can be used as a key starting materials to synthesize some important Schiff base 4 and fused heterocyclic compounds e.g. Imidazolo-[4,5-c]pyrazole 5, Pyrazolo[3,4-e]1,2,4-triazine 6, pyrazol[1,2-a] 1,3,5-triazine 7, 8 and 9. The electromeric effect of the halogen atom in the aryl moieties can be controlled upon the rate of reaction and the yield of the product. The structures of synthesized new compounds were characterized by spectral data and screened for their antimicrobial activities against various bacteria and fungi strains. The heterocyclic compounds 7, 8 and 9 that contained bridgehead nitrogen gave an excellent result.

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