ChemInform Abstract: MECHANISMS OF DIAZO COUPLING REACTIONS. PART XXX. N-DIAZO COUPLING OF P-CHLOROANILINE IN ACETONITRILE: RATE-LIMITING PROTON TRANSFER

1982 ◽  
Vol 13 (1) ◽  
Author(s):  
J. R. PENTON ◽  
H. ZOLLINGER
Keyword(s):  
Proton Transfer ◽  
Coupling Reactions ◽  
Diazo Coupling ◽  
Rate Limiting

scholarly journals New Diazo Coupling Reactions for Visible Spectrophotometric Determination of Alfuzosin in Pharmaceutical Preparations

2007 ◽  
Vol 4 (4) ◽  
pp. 496-501 ◽  
Author(s):  
M. Vamsi Krishna ◽  
D. Gowri Sankar
Keyword(s):  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Basic Medium ◽  
Coupling Reactions ◽  
Acetyl Acetone ◽  
Diazo Coupling ◽  
Optimum Reaction ◽  
Diazonium Ion

Simple, rapid and sensitive spectrophotometric procedures were developed for the analysis of Alfuzosin hydrochloride (AFZ) in pure form as well as in pharmaceutical formulations. The methods are based on the reaction of AFZ with nitrite in acid medium to form diazonium ion, which is coupled with ethoxyethylenemaleic ester (Method A) or ethylcyanoacetate (Method B) or acetyl acetone (method C) in basic medium to form azo dyes, showing absorption maxima at 440, 465 and 490 nm respectively. Beer’s law is obeyed in the concentration of 4-20 μg/mL of AFZ for methods A, B and 3-15 μg/mL of AFZ for method C. The molar absorptivity and sandell’s sensitivity of AFZ- ethoxyethylenemaleic ester, AFZ- ethylcyanoacetate and AFZ-acetyl acetone are1.90 × 104, 0.022; 1.93 × 104, 0.021 and 2.67 × 104L mole-1cm-1, 0.015 μg cm-2respectively. The optimum reaction conditions and other analytical parameters were evaluated. The methods were successfully applied to the determination of AFZ in pharmaceutical formulations.

Proton transfer is not rate-limiting in buffer-induced non-enzymic glucation of hemoglobin

1988 ◽  
Vol 110 (24) ◽  
pp. 8265-8266 ◽  
Author(s):  
Herminia. Gil ◽  
Julio F. Mata-Segreda ◽  
Richard L. Schowen
Keyword(s):  
Proton Transfer ◽  
Rate Limiting

scholarly journals Study of Kinetics, Equilibrium and the Influence of Steric Effects on Proton-Transfer in the Reactions of 2, 2, 4- and 2, 6- Substituted Anilines with 2-Phenoxy-3,5-dinitropyridine in DMSO

2010 ◽  
Vol 7 (1) ◽  
pp. 253-259 ◽  
Author(s):  
Basim H. Asghar
Keyword(s):  
Proton Transfer ◽  
Steric Effect ◽  
Nucleophilic Attack ◽  
Steric Effects ◽  
Substituted Anilines ◽  
Phenoxy Group ◽  
Kinetics Studies ◽  
Zwitterionic Intermediate ◽  
Rate Limiting ◽  
Step Mechanism

Kinetic and equilibrium results for the reactions of 2-phenoxy-3,5-dinitropyridine (1), with a series of 2, 2, 4- and 2, 6- substituted anilines (2a-f), in the presence of DABCO in DMSO are reported. The reactions yield the 2-anilino derivatives (5), without the accumulation of intermediates. Kinetics studies are compatible with a two-step mechanism involving initial nucleophilic attack by amine at the ring carbon substituted by phenoxy group followed by either base-catalyzed or uncatalyzed conversion to the product. The base-catalyzed pathway is likely to involve rate-limiting proton-transfer from the zwitterionic intermediate to base. This work indicates a steric effect to proton transfer in reactions involving 2, 6-disubstituted anilines. The results were compared with those for reactions of 1, 3, 5-trinitrobenzene with anilines.

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