ChemInform Abstract: DIRECT FORMATION OF THE STEROID NUCLEUS BY A BIOMIMETIC CYCLIZATION

1980 ◽  
Vol 11 (16) ◽  
Author(s):  
W. S. JOHNSON ◽  
B. E. MCCARRY ◽  
R. L. MARKEZICH ◽  
S. G. BOOTS
Keyword(s):  
Steroid Nucleus ◽  
Direct Formation ◽  
Biomimetic Cyclization

Direct formation of the steroid nucleus by a biomimetic cyclization

1980 ◽  
Vol 102 (1) ◽  
pp. 352-359 ◽  
Author(s):  
William S. Johnson ◽  
Brian E. McCarry ◽  
R. L. Markezich ◽  
Sharon G. Boots
Keyword(s):  
Steroid Nucleus ◽  
Direct Formation ◽  
Biomimetic Cyclization

ChemInform Abstract: DIRECT FORMATION OF THE STEROID NUCLEUS BY A NONENZYMIC BIOGENETIC-LIKE CYCLIZATION, PREPARATION OF THE CYCLIZATION SUBSTRATE

1973 ◽  
Vol 4 (36) ◽  
pp. no-no
Author(s):  
RONALD L. MARKEZICH ◽  
W. EDWARD WILLY ◽  
BRIAN E. MCCARRY ◽  
WILLIAM S. JOHNSON
Keyword(s):  
Steroid Nucleus ◽  
Direct Formation

Direct formation of the steroid nucleus by a nonenzymic biogenetic-like cyclization. Preparation of the cyclization substrate

1973 ◽  
Vol 95 (13) ◽  
pp. 4414-4416 ◽  
Author(s):  
Ronald L. Markezich ◽  
W. Edward. Willy ◽  
Brian E. McCarry ◽  
William S. Johnson
Keyword(s):  
Steroid Nucleus ◽  
Direct Formation

Phytosterols and Triterpenoids for Prevention and Treatment of Metabolic-related Liver Diseases and Hepatocellular Carcinoma

2019 ◽  
Vol 20 (3) ◽  
pp. 197-214 ◽  
Author(s):  
Isabel Sánchez-Crisóstomo ◽  
Eduardo Fernández-Martínez ◽  
Raquel Cariño-Cortés ◽  
Gabriel Betanzos-Cabrera ◽  
Rosa A. Bobadilla-Lugo
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Anticancer Agents ◽  
Liver Diseases ◽  
Membrane Receptors ◽  
New Drugs ◽  
Sexual Hormones ◽  
Steroid Nucleus ◽  
Alcoholic Fatty Liver ◽  
Prevention And Treatment

Background: Liver ailments are among the leading causes of death; they originate from viral infections, chronic alcoholism, and autoimmune illnesses, which may chronically be precursors of cirrhosis; furthermore, metabolic syndrome may worsen those hepatopathies or cause Non-alcoholic Fatty Liver Disease (NAFLD) that may advance to non-alcoholic steatohepatitis (NASH). Cirrhosis is the late-stage liver disease and can proceed to hepatocellular carcinoma (HCC). Pharmacological treatment options for liver diseases, cirrhosis, and HCC, are limited, expensive, and not wholly effective. The use of medicinal herbs and functional foods is growing around the world as natural resources of bioactive compounds that would set the basis for the development of new drugs. Review and Conclusion: Plant and food-derived sterols and triterpenoids (TTP) possess antioxidant, metabolic-regulating, immunomodulatory, and anti-inflammatory activities, as well as they are recognized as anticancer agents, suggesting their application strongly as an alternative therapy in some chronic diseases. Thus, it is interesting to review current reports about them as hepatoprotective agents, but also because they structurally resemble cholesterol, sexual hormones, corticosteroids and bile acids due to the presence of the steroid nucleus, so they all can share pharmacological properties through activating nuclear and membrane receptors. Therefore, sterols and TTP appear as a feasible option for the prevention and treatment of chronic metabolic-related liver diseases, cirrhosis, and HCC.

scholarly journals Further Studies on the 3-Ketosteroid 9α-Hydroxylase of Rhodococcus ruber Chol-4, a Rieske Oxygenase of the Steroid Degradation Pathway

2021 ◽  
Vol 9 (6) ◽  
pp. 1171
Author(s):  
Sara Baldanta ◽  
Juana María Navarro Llorens ◽  
Govinda Guevara
Keyword(s):  
Cholesterol Metabolism ◽  
Genetic Regulation ◽  
Degradation Pathway ◽  
Rhodococcus Ruber ◽  
Promoter Regions ◽  
Steroid Nucleus ◽  
Steroid Substrate ◽  
Fine Regulation ◽  
Rieske Oxygenase ◽  
Steroid Catabolism

The biochemistry and genetics of the bacterial steroid catabolism have been extensively studied during the last years and their findings have been essential to the development of biotechnological applications. For instance, metabolic engineering of the steroid-eater strains has allowed to obtain intermediaries of industrial value. However, there are still some drawbacks that must be overcome, such as the redundancy of the steroid catabolism genes in the genome and a better knowledge of its genetic regulation. KshABs and KstDs are key enzymes involved in the aerobic breakage of the steroid nucleus. Rhodococcus ruber Chol-4 contains three kshAs genes, a single kshB gene and three kstDs genes within its genome. In the present work, the growth of R. ruber ΔkshA strains was evaluated on different steroids substrates; the promoter regions of these genes were analyzed; and their expression was followed by qRT-PCR in both wild type and ksh mutants. Additionally, the transcription level of the kstDs genes was studied in the ksh mutants. The results show that KshA2B and KshA1B are involved in AD metabolism, while KshA3B and KshA1B contribute to the cholesterol metabolism in R. ruber. In the kshA single mutants, expression of the remaining kshA and kstD genes is re-organized to survive on the steroid substrate. These data give insight into the fine regulation of steroid genes when several isoforms are present.

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