ChemInform Abstract: REACTION OF THE DIETHYL ESTER OF DICARBETHOXYMETHYLPHOSPHONOUS ACID WITH α-KETOCARBOXYLIC ESTERS

1978 ◽  
Vol 9 (50) ◽  
Author(s):  
I. V. KONOVALOVA ◽  
L. A. BURNAEVA ◽  
O. A. MOLCHANOVA ◽  
A. N. PUDOVIK
Keyword(s):  
Diethyl Ester

scholarly journals d-Cystine di(m)ethyl ester reverses the deleterious effects of morphine on ventilation and arterial blood gas chemistry while promoting antinociception

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Benjamin Gaston ◽  
Santhosh M. Baby ◽  
Walter J. May ◽  
Alex P. Young ◽  
Alan Grossfield ◽  
...  
Keyword(s):  
Gas Exchange ◽  
Intracellular Signaling ◽  
Dimethyl Ester ◽  
Diethyl Ester ◽  
Blood Gas ◽  
Negative Effects ◽  
Arterial Blood Gas ◽  
Arterial Blood ◽  
Gas Chemistry ◽  
Ventilatory Drive

AbstractWe have identified thiolesters that reverse the negative effects of opioids on breathing without compromising antinociception. Here we report the effects of d-cystine diethyl ester (d-cystine diEE) or d-cystine dimethyl ester (d-cystine diME) on morphine-induced changes in ventilation, arterial-blood gas chemistry, A-a gradient (index of gas-exchange in the lungs) and antinociception in freely moving rats. Injection of morphine (10 mg/kg, IV) elicited negative effects on breathing (e.g., depression of tidal volume, minute ventilation, peak inspiratory flow, and inspiratory drive). Subsequent injection of d-cystine diEE (500 μmol/kg, IV) elicited an immediate and sustained reversal of these effects of morphine. Injection of morphine (10 mg/kg, IV) also elicited pronounced decreases in arterial blood pH, pO2 and sO2 accompanied by pronounced increases in pCO2 (all indicative of a decrease in ventilatory drive) and A-a gradient (mismatch in ventilation-perfusion in the lungs). These effects of morphine were reversed in an immediate and sustained fashion by d-cystine diME (500 μmol/kg, IV). Finally, the duration of morphine (5 and 10 mg/kg, IV) antinociception was augmented by d-cystine diEE. d-cystine diEE and d-cystine diME may be clinically useful agents that can effectively reverse the negative effects of morphine on breathing and gas-exchange in the lungs while promoting antinociception. Our study suggests that the d-cystine thiolesters are able to differentially modulate the intracellular signaling cascades that mediate morphine-induced ventilatory depression as opposed to those that mediate morphine-induced antinociception and sedation.

Synthesis of ?-organosilyl derivatives of propylphosphonic bichloride and diethyl ester

1962 ◽  
Vol 11 (6) ◽  
pp. 937-940
Author(s):  
E. A. Chernyshev ◽  
E. F. Bugerenko ◽  
E. D. Lubuzh ◽  
A. D. Petrov
Keyword(s):  
Diethyl Ester ◽  
Derivatives Of

Rapid, mild method for phosphonate diester hydrolysis: development of a one-pot synthesis of tenofovir disoproxil fumarate from tenofovir diethyl ester

Tetrahedron ◽  
2010 ◽  
Vol 66 (41) ◽  
pp. 8137-8144 ◽  
Author(s):  
Stephen R. Houghton ◽  
Jack Melton ◽  
Joseph Fortunak ◽  
David H. Brown Ripin ◽  
Christopher N. Boddy
Keyword(s):  
Tenofovir Disoproxil Fumarate ◽  
Diethyl Ester ◽  
One Pot ◽  
One Pot Synthesis

A coordination polymer derived from the copper(II) complex of a bis-(salicylhydrazone) derived from iminodiacetic acid diethyl ester

2000 ◽  
Vol 3 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Harry Adams ◽  
David E Fenton* ◽  
Giovannina Minardi ◽  
Emanuela Mura ◽  
Angelo M Pistuddi ◽  
...  
Keyword(s):  
Coordination Polymer ◽  
Iminodiacetic Acid ◽  
Diethyl Ester
Sign in / Sign up

Export Citation Format

Share Document