ChemInform Abstract: SYNTHESIS AND BIOLOGICAL PROPERTIES OF DERIVATIVES OF 2-CHLORONAPHTHO(1,2-D)IMIDAZOLYL-3-ACETIC ACID HYDRAZIDE

1978 ◽  
Vol 9 (40) ◽  
Author(s):  
M. V. POVSTYANOI ◽  
E. A. YAKUBOVSKII ◽  
M. P. STEBLYUK
Keyword(s):  
Acetic Acid ◽  
Acid Hydrazide ◽  
Biological Properties ◽  
Derivatives Of

Synthesis and biological properties of 2-chloronaphtho[1,2-d] imidazolyl-3-acetic acid hydrazide

1978 ◽  
Vol 12 (4) ◽  
pp. 455-458
Author(s):  
M. V. Povstyanoi ◽  
E. A. Yakubovskii ◽  
P. M. Steblyuk
Keyword(s):  
Acetic Acid ◽  
Acid Hydrazide ◽  
Biological Properties

scholarly journals Spectral and Microbial Studies of some Newly Synthesized Schiff Base Derivatives of 2-(1H-Benzo[d]Oxazole-2-ylthio)-N-(4-Acetylphenyl)Acetamide

2015 ◽  
Vol 44 ◽  
pp. 57-65
Author(s):  
J.J. Maru ◽  
G.R. Patel ◽  
Rakesh Yadav
Keyword(s):  
Acetic Acid ◽  
Acid Hydrazide ◽  
Catalytic Amount ◽  
Spectroscopic Techniques ◽  
Antibacterial Effects ◽  
Azomethine Group ◽  
Schiff Base Derivatives ◽  
Inhibition Concentration ◽  
New Compounds ◽  
Derivatives Of

The author has synthesized novel biological active compounds by condensation of N-(4-Acetyl-phenyl)-2-(benzooxazol-2-ylsulfanyl)-acetamide with defferent substituted of acid hydrazide in the presence of catalytic amount of acetic acid. A series of benzoxazole having azomethine group were confirmed by various spectroscopic techniques. The new compounds were examined for antibacterial effects again different strain of bacteria and antifungal were high to lowest Minimum Inhibition Concentration (MIC) values.

Synthesis and biological properties of derivatives of (3-methyl-8-bromxanthinyl-7) acetic acid

1986 ◽  
Vol 20 (11) ◽  
pp. 769-772 ◽  
Author(s):  
N. I. Romanenko ◽  
I. V. Fedulova ◽  
B. A. Priimenko ◽  
A. Yu. Chervinskii ◽  
N. A. Klyuev ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Biological Properties ◽  
Derivatives Of

Fluorinated tricyclic neuroleptics with prolonged action: 8-Methoxy, 8-ethoxy, 8-ethylthio and 8-hydroxy derivatives of 3-fluoro-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin

1982 ◽  
Vol 47 (5) ◽  
pp. 1382-1391 ◽  
Author(s):  
Jiří Jílek ◽  
Josef Pomykáček ◽  
Jiřina Metyšová ◽  
Miroslav Protiva
Keyword(s):  
Acetic Acid ◽  
Polyphosphoric Acid ◽  
Prolonged Action ◽  
Substitution Reactions ◽  
Methoxy Derivative ◽  
Chloro Derivatives ◽  
Boron Tribromide ◽  
Derivatives Of ◽  
Central Depressant ◽  
Boiling Toluene

Acids IIa-c were prepared by reactions of (4-fluoro-2-iodophenyl)acetic acid with 4-methoxythiophenol, 4-ethoxythiophenol and 4-(ethylthio)thiophenol and cyclized with polyphosphoric acid in boiling toluene to dibenzo[b,f]thiepin-10(11H)-ones IIIa-c. Reduction with sodium borohydride afforded the alcohols IVa-c which were treated with hydrogen chloride and gave the chloro derivatives Va-c. Substitution reactions with 1-methylpiperazine resulted in the title compounds Ia-c out of which the methoxy derivative Ia was transformed by demethylation with boron tribromide to the phenol Id. Compounds Ia-d are very potent neuroleptics exhibiting a clear prolongation of the central depressant and some prolongation of the cataleptic activity.

Sign in / Sign up

Export Citation Format

Share Document