ChemInform Abstract: STUDIES ON CHEMICAL ALTERATIONS OF NUCLEIC ACIDS AND THEIR COMPONENTS PART 6, N-AMINATION OF SOME NUCLEIC ACID BASES CONTAINING BASIC NITROGEN WITH HYDROXYLAMINE-O-ESTERS

1974 ◽  
Vol 5 (7) ◽  
pp. no-no
Author(s):  
G.-F. HUANG ◽  
T. OKAMOTO ◽  
M. MAEDA ◽  
Y. KAWAZOE
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Nucleic Acid Bases ◽  
Basic Nitrogen

Binding of metal ions and water molecules to nucleic acid bases: the influence of water molecule coordination to a metal ion on water–nucleic acid base hydrogen bonds

2019 ◽  
Vol 75 (3) ◽  
pp. 301-309
Author(s):  
Jelena M. Andrić ◽  
Ivana M. Stanković ◽  
Snežana D. Zarić
Keyword(s):  
Nucleic Acid ◽  
Hydrogen Bonds ◽  
Nucleic Acids ◽  
Metal Ions ◽  
Quantum Chemical Calculations ◽  
Quantum Chemical ◽  
Metal Ion ◽  
Water Molecules ◽  
Nucleic Acid Bases ◽  
Coordinated Water

The interactions of nucleic acid bases with non-coordinated and coordinated water molecules were studied by analyzing data in the Protein Data Bank (PDB) and by quantum chemical calculations. The analysis of the data in the crystal structures from the PDB indicates that hydrogen bonds involving oxygen or nitrogen atoms of nucleic acid bases and water molecules are shorter when water is bonded to a metal ion. These results are in agreement with the quantum chemical calculations on geometries and interaction energies of hydrogen bonds; the calculations on model systems show that hydrogen bonds of nucleic acid bases with water bonded to a metal ion are stronger than hydrogen bonds with non-coordinated water. These calculated values are similar to the strength of hydrogen bonds between nucleic acid bases. The results presented in this paper may be relevant to understand the role of water molecules and metal ions in the process of replication and stabilization of nucleic acids and also to understand the possible toxicity of metal ion interactions with nucleic acids.

scholarly journals Chemical structure of QAII, one of the covalently bound adducts of carcinogenic 4-nitroquinoline 1-oxide with nucleic acid bases of cellular nucleic acids.

1975 ◽  
Vol 23 (11) ◽  
pp. 3041-3043 ◽  
Author(s):  
YUTAKA KAWAZOE ◽  
MISAKO ARAKI ◽  
GUANGFU HUANG ◽  
TOSHIHIKO OKAMOTO ◽  
MITSUHIKO TADA ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Chemical Structure ◽  
Nucleic Acid Bases ◽  
Covalently Bound

PROTONATED CARBONYL GROUPS: VIII. ALKYLURACIL SALTS

1966 ◽  
Vol 44 (3) ◽  
pp. 335-344 ◽  
Author(s):  
Denys Cook
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Carbonyl Group ◽  
Group Analysis ◽  
Spectroscopic Methods ◽  
Carbonyl Groups ◽  
Nucleic Acid Bases ◽  
Base Pairing ◽  
Infrared Spectroscopic ◽  
Hydrogen Deuterium

With 1,3-dimethyluracil and 1,3,6-trimethyluracil as models for nucleic acid bases, it was found by infrared spectroscopic methods that the site of protonation is a carbonyl group. Analysis of other evidence makes it likely that it is the carbonyl group in position 4. In 1,3,6-trimethyluracil salts, activation of the 5 position under acid conditions permits ready hydrogen–deuterium exchange.Some anomalous 2 base – 1 acid salts with complex acids are considered in the light of base pairing errors in nucleic acids.

Nucleic Acid Molecules Prepared by Monolayer Techniques

1972 ◽  
Vol 30 ◽  
pp. 178-179
Author(s):  
Dimitrij Lang
Keyword(s):  
Electron Microscopy ◽  
Standard Deviation ◽  
Nucleic Acid ◽  
Cytochrome C ◽  
Nucleic Acids ◽  
Contour Length ◽  
Sample Standard Deviation ◽  
Molecular Weights ◽  
Length Measurements ◽  
Protein Monolayer

The success of the protein monolayer technique for electron microscopy of individual DNA molecules is based on the prevention of aggregation and orientation of the molecules during drying on specimen grids. DNA adsorbs first to a surface-denatured, insoluble cytochrome c monolayer which is then transferred to grids, without major distortion, by touching. Fig. 1 shows three basic procedures which, modified or not, permit the study of various important properties of nucleic acids, either in concert with other methods or exclusively:1) Molecular weights relative to DNA standards as well as number distributions of molecular weights can be obtained from contour length measurements with a sample standard deviation between 1 and 4%.

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