scholarly journals Synthesis and Cellular Labeling of Caged Phosphatidylinositol Derivatives

2019 ◽  
Vol 26 (2) ◽  
pp. 384-389 ◽  
Author(s):  
Rainer Müller ◽  
Mevlut Citir ◽  
Sebastian Hauke ◽  
Carsten Schultz
Keyword(s):  
Cellular Labeling

scholarly journals Mesenchymal Stem Cells Do Not Lose Direct Labels Including Iron Oxide Nanoparticles and DFO-89Zr Chelates through Secretion of Extracellular Vesicles

Membranes ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 484
Author(s):  
Yue Gao ◽  
Anna Jablonska ◽  
Chengyan Chu ◽  
Piotr Walczak ◽  
Miroslaw Janowski
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Extracellular Vesicles ◽  
Superparamagnetic Iron Oxide ◽  
Cell Labeling ◽  
Oxide Nanoparticles ◽  
Stem Cell Delivery ◽  
Cellular Labeling

Rapidly ageing populations are beset by tissue wear and damage. Stem cell-based regenerative medicine is considered a solution. Years of research point to two important aspects: (1) the use of cellular imaging to achieve sufficient precision of therapeutic intervention, and the fact that (2) many therapeutic actions are executed through extracellular vesicles (EV), released by stem cells. Therefore, there is an urgent need to interrogate cellular labels in the context of EV release. We studied clinically applicable cellular labels: superparamagnetic iron oxide nanoparticles (SPION), and radionuclide detectable by two main imaging modalities: MRI and PET. We have demonstrated effective stem cell labeling using both labels. Then, we obtained EVs from cell cultures and tested for the presence of cellular labels. We did not find either magnetic or radioactive labels in EVs. Therefore, we report that stem cells do not lose labels in released EVs, which indicates the reliability of stem cell magnetic and radioactive labeling, and that there is no interference of labels with EV content. In conclusion, we observed that direct cellular labeling seems to be an attractive approach to monitoring stem cell delivery, and that, importantly, labels neither locate in EVs nor affect their basic properties.

scholarly journals Synthesis and cellular labeling of multifunctional phosphatidylinositol bis‐ and trisphosphate derivatives

2021 ◽  
Author(s):  
Rainer Mueller ◽  
Ana Kojic ◽  
Mevlut Citir ◽  
Carsten Schultz
Keyword(s):  
Cellular Labeling

Curauá-derived carbon dots: Fluorescent probes for effective Fe(III) ion detection, cellular labeling and bioimaging

2021 ◽  
pp. 112409
Author(s):  
Sebastian Raja ◽  
Eva Miriam Buhl ◽  
Stephan Dreschers ◽  
Carmen Schalla ◽  
Martin Zenke ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Carbon Dots ◽  
Ion Detection ◽  
Cellular Labeling

scholarly journals Cellular labeling with Gd(III) chelates: only high thermodynamic stabilities prevent the cells acting as ‘sponges’ of Gd3+ ions

2006 ◽  
Vol 1 (1) ◽  
pp. 23-29 ◽  
Author(s):  
C. Cabella ◽  
S. Geninatti Crich ◽  
D. Corpillo ◽  
A. Barge ◽  
C. Ghirelli ◽  
...  
Keyword(s):  
Cellular Labeling

ChemInform Abstract: MRI Paramagnetic Probes for Cellular Labeling

ChemInform ◽  
2012 ◽  
Vol 43 (29) ◽  
pp. no-no
Author(s):  
Eliana Gianolio ◽  
Rachele Stefania ◽  
Enza Di Gregorio ◽  
Silvio Aime
Keyword(s):  
Paramagnetic Probes ◽  
Cellular Labeling

MRI Paramagnetic Probes for Cellular Labeling

2012 ◽  
Vol 2012 (12) ◽  
pp. 1934-1944 ◽  
Author(s):  
Eliana Gianolio ◽  
Rachele Stefania ◽  
Enza Di Gregorio ◽  
Silvio Aime
Keyword(s):  
Paramagnetic Probes ◽  
Cellular Labeling
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