“On‐Water” Palladium‐Catalyzed Tandem Cyclization Reaction for the Synthesis of Biologically Relevant 4‐Arylquinazolines

2019 ◽  
Vol 25 (57) ◽  
pp. 13109-13113 ◽  
Author(s):  
Shuo Yuan ◽  
Bin Yu ◽  
Hong‐Min Liu
Keyword(s):  
Cyclization Reaction ◽  
Biologically Relevant ◽  
Palladium Catalyzed ◽  
Tandem Cyclization

scholarly journals Palladium-catalyzed three-component tandem cyclization of buta-2,3-dien-1-ol, aryl iodides, and imines: an efficient protocol for the synthesis of oxazolidine derivatives

RSC Advances ◽  
2017 ◽  
Vol 7 (12) ◽  
pp. 7401-7405 ◽  
Author(s):  
Yunlei Hou ◽  
Mingze Qin ◽  
Xiuxiu Yang ◽  
Qi Shen ◽  
Yanfang Zhao ◽  
...  
Keyword(s):  
Cyclization Reaction ◽  
Aryl Iodides ◽  
Palladium Catalyzed ◽  
Tandem Cyclization

An efficient three-component tandem cyclization reaction for the synthesis of highly substituted oxazolidines was achieved through the Pd0-catalyzed cyclization of buta-2,3-dien-1-ol with aryl iodides and imines.

Palladium-catalyzed intermolecular tandem cyclization reaction: a highly regioselective synthesis of functionalized 3H-spiro[isobenzofuran-1,3′-isochroman] scaffolds

2017 ◽  
Vol 15 (11) ◽  
pp. 2403-2410 ◽  
Author(s):  
Liang Wang ◽  
Xuehu Li ◽  
Hua Tao ◽  
Xiang Zhou ◽  
Xihong Lu ◽  
...  
Keyword(s):  
Cyclization Reaction ◽  
Regioselective Synthesis ◽  
Palladium Catalyzed ◽  
Tandem Cyclization

A highly regioselective synthesis of functionalized 3H-spiro[isobenzofuran-1,3′-isochroman] scaffolds via palladium-catalyzed tandem cyclization.

Synthesis of Novel Bis-pyrazoles via Electrophilic Cyclization

2019 ◽  
Vol 16 (6) ◽  
pp. 511-516
Author(s):  
Adnan Cetin
Keyword(s):  
13C Nmr ◽  
Cyclization Reaction ◽  
Electrophilic Cyclization ◽  
Pyrazole Derivatives ◽  
Spectral Analyses ◽  
Mass Spectral ◽  
Palladium Catalyzed ◽  
Ft Ir ◽  
Reaction Compound

Efficient steps towards the synthesis of novel (phenyl)(1'-aryl-1,5,5'-triphenyl[3,3'-bi-1Hpyrazol]- 4-yl)methanones 4a-e were developed. The procedure starts from 1-(4-benzoyl-1,5-diphenyl- 1H-3-pyrazolyl)-3-phenyl-2-propyn-1-one (2) which was synthesized by a palladium catalyzed crosscoupling reaction. Compound 2 reacted with various hydrazines to give (E)-(phenyl)[1,5-diphenyl-3- [3-phenyl-1-(2-arylhydrazono)-2-propyn-1-yl]-1H-4-pyrazolyl]methanones E-3a-e. The bis-pyrazole derivatives 4a-e were synthesized from electrophilic cyclization reaction of α,β-acetylenic hydrazones E-3a-e and copper(I) iodide. All synthesized compounds were characterized by FT-IR, 1H, 13C NMR and Mass spectral analyses.

scholarly journals Palladium-Catalyzed Tandem Cyclization/Suzuki Coupling of 1,6-Enynes: Reaction Scope and Mechanism.

ChemInform ◽  
2005 ◽  
Vol 36 (31) ◽  
Author(s):  
Gangguo Zhu ◽  
Xiaofeng Tong ◽  
Jiang Cheng ◽  
Yanhui Sun ◽  
Dao Li ◽  
...  
Keyword(s):  
Suzuki Coupling ◽  
Palladium Catalyzed ◽  
Tandem Cyclization

Tandem cyclization of o-alkynylanilines with isocyanides triggered by intramolecular nucleopalladation: access to heterocyclic fused 2-aminoquinolines

2018 ◽  
Vol 54 (50) ◽  
pp. 6855-6858 ◽  
Author(s):  
Wanqing Wu ◽  
Meng Li ◽  
Jia Zheng ◽  
Weigao Hu ◽  
Chunsheng Li ◽  
...  
Keyword(s):  
Palladium Catalyzed ◽  
Tandem Cyclization ◽  
Novel Strategy

A novel strategy for the synthesis of heterocyclic fused 2-aminoquinolines via palladium-catalyzed tandem cyclization of o-alkynylanilines and isocyanides has been developed.

Palladium‐Catalyzed Cascade Carbonylative Cyclization Reaction of Trifluoroacetimidoyl Chlorides and 2‐Iodoanilines: Toward 2‐(Trifluoromethyl)quinazolin‐4(3H)‐ones Synthesis

2020 ◽  
Vol 5 (35) ◽  
pp. 11072-11076 ◽  
Author(s):  
Hefei Yang ◽  
Le‐Cheng Wang ◽  
Wei‐Feng Wang ◽  
Zhengkai Chen ◽  
Xiao‐Feng Wu
Keyword(s):  
Cyclization Reaction ◽  
Palladium Catalyzed

Synthesis of 4-styrylcoumarins via FeCl3-promoted cascade reactions of propargylamines with β-keto esters

2019 ◽  
Vol 17 (16) ◽  
pp. 4005-4013 ◽  
Author(s):  
Li-Qin Yan ◽  
Xiaoting Cai ◽  
Xinwei He ◽  
Hui Wang ◽  
Mengqing Xie ◽  
...  
Keyword(s):  
Cascade Reactions ◽  
Cyclization Reaction ◽  
Quinone Methides ◽  
Keto Esters ◽  
Tandem Cyclization

A versatile and highly regioselective FeCl3-promoted tandem cyclization reaction of in situ generated alkynyl o-quinone methides (o-AQMs) with β-keto esters has been developed.

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