Efforts towards an On‐Target Version of the Groebke–Blackburn–Bienaymé (GBB) Reaction for Discovery of Druglike Urokinase (uPA) Inhibitors

2019 ◽  
Vol 25 (53) ◽  
pp. 12380-12393 ◽  
Author(s):  
Rafaela Gladysz ◽  
Johannes Vrijdag ◽  
Dries Van Rompaey ◽  
Anne‐Marie Lambeir ◽  
Koen Augustyns ◽  
...  
Keyword(s):  
Gbb Reaction

Synthesis and photophysical properties of 5-(3''-alkyl/aryl-amino-1''-azaindolizin-2''-yl)-2'-deoxyuridines

2021 ◽  
Author(s):  
Sandeep Kumar ◽  
Sumit Kumar ◽  
Jyotirmoy Maity ◽  
Banty Kumar ◽  
Shilpika Bali ◽  
...  
Keyword(s):  
Photophysical Properties ◽  
Efficient Synthesis ◽  
Alkyl Aryl ◽  
Gbb Reaction

Groebke-Blackburn-Bienayame (GBB) reaction has been used for the efficient synthesis of novel fluorescent 5-azaindolizino-2'-deoxyuridines starting from commercially available thymidine following two strategies. Thus, thymidine was converted to diacetylthymidine, which on...

An approach towards the synthesis of novel fused nitrogen tricyclic heterocyclic scaffolds via GBB reaction

2018 ◽  
Vol 16 (8) ◽  
pp. 1287-1296 ◽  
Author(s):  
Sandip Gangadhar Balwe ◽  
Yeon Tae Jeong
Keyword(s):  
Cycloaddition Reaction ◽  
One Pot ◽  
One Pot Synthesis ◽  
Gbb Reaction

A concise and efficient one-pot synthesis of novel N-fused tricyclic derivatives has been developed by using the Groebke–Blackburn–Bienaymé (GBB) reaction, which involved the reaction of 3-amino-1H-indazoles, aldehydes and isonitriles to afford 2-aryl-5H-imidazo[1,2-b]indazol-3-amine derivatives via a formal [4 + 1] cycloaddition reaction.

scholarly journals Facile synthesis of 1H-imidazo[1,2-b]pyrazoles via a sequential one-pot synthetic approach

2014 ◽  
Vol 10 ◽  
pp. 2338-2344 ◽  
Author(s):  
András Demjén ◽  
Márió Gyuris ◽  
János Wölfling ◽  
László G Puskás ◽  
Iván Kanizsai
Keyword(s):  
Building Blocks ◽  
Synthetic Approach ◽  
Facile Synthesis ◽  
One Pot ◽  
Rapid Construction ◽  
Gbb Reaction

5-Aminopyrazole-4-carbonitrile and ethyl 5-aminopyrazole-4-carboxylate, as potential trifunctional building blocks are introduced in a facile, chemo- and regioselective multicomponent assembly of imidazo[1,2-b]pyrazoles via the Groebke–Blackburn–Bienaymé reaction (GBB reaction). Besides the synthetic elaboration of a green-compatible isocyanide-based access in three-component mode, we describe an operationally simple, one-pot two-step GBB protocol for the rapid construction of a 46 membered imidazo[1,2-b]pyrazole library with yields up to 83%.

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