An approach towards the synthesis of novel fused nitrogen tricyclic heterocyclic scaffolds via GBB reaction
2018 ◽
Vol 16
(8)
◽
pp. 1287-1296
◽
A concise and efficient one-pot synthesis of novel N-fused tricyclic derivatives has been developed by using the Groebke–Blackburn–Bienaymé (GBB) reaction, which involved the reaction of 3-amino-1H-indazoles, aldehydes and isonitriles to afford 2-aryl-5H-imidazo[1,2-b]indazol-3-amine derivatives via a formal [4 + 1] cycloaddition reaction.