In Situ Proteome Profiling and Bioimaging Applications of Small-Molecule Affinity-Based Probes Derived From DOT1L Inhibitors

2016 ◽  
Vol 22 (23) ◽  
pp. 7824-7836 ◽  
Author(s):  
Biwei Zhu ◽  
Hailong Zhang ◽  
Sijun Pan ◽  
Chenyu Wang ◽  
Jingyan Ge ◽  
...  
Keyword(s):  
Small Molecule ◽  
Proteome Profiling

A new method for the in situ assay of α-glucosidase activity and inhibitor screening through an enzyme substrate-mediated DNA hybridization chain reaction

2019 ◽  
Vol 43 (24) ◽  
pp. 9458-9465
Author(s):  
Xiquan Yue ◽  
Lihong Su ◽  
Xu Chen ◽  
Junfeng Liu ◽  
Longpo Zheng ◽  
...  
Keyword(s):  
Small Molecule ◽  
Dna Hybridization ◽  
New Method ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Inhibitor Screening ◽  
Glucosidase Activity ◽  
Enzyme Substrate ◽  
In Situ Assay

The strategy is based on small molecule-mediated hybridization chain reaction.

scholarly journals Backbonding contributions to small molecule chemisorption in a metal–organic framework with open copper(i) centers

2021 ◽  
Author(s):  
Gregory M. Su ◽  
Han Wang ◽  
Brandon R. Barnett ◽  
Jeffrey R. Long ◽  
David Prendergast ◽  
...  
Keyword(s):  
Fine Structure ◽  
Small Molecule ◽  
Metal Organic Framework ◽  
X Ray ◽  
Metal Site ◽  
Absorption Fine ◽  
Metal Organic ◽  
X Ray Absorption ◽  
Organic Framework

In situ near edge X-ray absorption fine structure spectroscopy directly probes unoccupied states associated with backbonding interactions between the open metal site in a metal–organic framework and various small molecule guests.

Effects of water vapor and oxygen on non-fullerene small molecule acceptors

2019 ◽  
Vol 7 (4) ◽  
pp. 879-886 ◽  
Author(s):  
Chuanfei Wang ◽  
Shaofei Ni ◽  
Slawomir Braun ◽  
Mats Fahlman ◽  
Xianjie Liu
Keyword(s):  
Thermal Stress ◽  
Water Vapor ◽  
Small Molecule ◽  
Photoelectron Spectroscopy

Tolerance of non-fullerene acceptors to water vapor, oxygen and thermal stress was investigated by photoelectron spectroscopy via the in situ method.

scholarly journals Pengembangan Metode DGT (Diffusive Gradient In Thin Film) dengan Binding Gel Fe-Al-Oksida dan Pengikat Silang N,N’-Methylenebisacrylamide untuk Penyerapan Fosfat dalam Air

2015 ◽  
pp. 20-25
Author(s):  
Asep Saefumullah ◽  
Ratsania Rahmaniati H
Keyword(s):  
Thin Film ◽  
Thin Films ◽  
Small Molecule ◽  
Aquatic Environment ◽  
Contact Time ◽  
Measurement Method ◽  
High Concentration ◽  
Accurate Analysis ◽  
Al Oxide

High concentration of phosphates in the water can lead to eutrophication which leads to uncontrolled growth of algae (algae blooming). It underlies the need for determining the concentration of phosphate in the aquatic environment. However, the concentration of phosphate may change during storage of samples so that an accurate analysis difficult to achieve unless carried out in-situ. DGT (Diffusive Gradient in Thin Films) is an in-situ measurement method developed for measuring phosphate and metal. In this study the use of Fe-Al-Oxide as a binding gel that is expected to bind phosphate with a capacity greater than ferrihydrite. N, N'-methylenebisacrylamide is used as a substitute for commercial DGT Crosslinker as crosslinking for a cheaper price and selective for small molecule. Ferrihydrite-DGT and Fe-Al-Oxide-DGT are tested with a variety of concentrations, pH, and contact time. In both methods DGT found that the pH for phosphate measurements performed at pH 3. Capacity of Fe-Al-Oxide binding gel known to be higher than the ferrihydrite binding gel with result Cferrihydrite-DGT:Cstart is 76% and CFe-Al-Oxide-DGT:Cstart is 82%.DOI :http://dx.doi.org/10.15408/jkv.v0i0.3597

scholarly journals Fluorohydration of alkynes via I(I)/I(III) catalysis

2020 ◽  
Vol 16 ◽  
pp. 1627-1635 ◽  
Author(s):  
Jessica Neufeld ◽  
Constantin G Daniliuc ◽  
Ryan Gilmour
Keyword(s):  
Substrate Specificity ◽  
Small Molecule ◽  
Physical Organic ◽  
Internal Alkynes ◽  
Biological Catalysis

Substrate specificity is ubiquitous in biological catalysis, but less pervasive in the realm of small-molecule catalysis. Herein, we disclose an intriguing example of substrate specificity that was observed whilst exploring catalysis-based routes to generate α-fluoroketones from terminal and internal alkynes under the auspices of I(I)/I(III) catalysis. Utilising p-TolI as an inexpensive organocatalyst with Selectfluor® and amine/HF mixtures, the formation of protected α-fluoroketones from simple alkynes was realised. Whilst the transient p-TolIF2 species generated in situ productively engaged with pentynyl benzoate scaffolds to generate the desired α-fluoroketone motif, augmentation or contraction of the linker suppressed catalysis. The prerequisite for this substructure was established by molecular editing and was complemented with a physical organic investigation of possible determinants.

scholarly journals Bioorthogonal cyclization-mediated in situ self-assembly of small-molecule probes for imaging caspase activity in vivo

2014 ◽  
Vol 6 (6) ◽  
pp. 519-526 ◽  
Author(s):  
Deju Ye ◽  
Adam J. Shuhendler ◽  
Lina Cui ◽  
Ling Tong ◽  
Sui Seng Tee ◽  
...  
Keyword(s):  
Small Molecule ◽  
Self Assembly ◽  
Caspase Activity ◽  
Small Molecule Probes

scholarly journals A Small Molecule Walks Along a Surface Between Porphyrin Fences That Are Assembled In Situ

2015 ◽  
Vol 54 (24) ◽  
pp. 7101-7105 ◽  
Author(s):  
Sam Haq ◽  
Bareld Wit ◽  
Hongqian Sang ◽  
Andrea Floris ◽  
Yu Wang ◽  
...  
Keyword(s):  
Small Molecule
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