Molecular Pom Poms from Self-Assembling α,γ-Cyclic Peptides

2014 ◽  
Vol 20 (33) ◽  
pp. 10260-10265 ◽  
Author(s):  
Michele Panciera ◽  
Manuel Amorín ◽  
Juan R. Granja
Keyword(s):  
Cyclic Peptides ◽  
Self Assembling

scholarly journals Self-Assembling Cyclic Peptides:  Molecular Dynamics Studies of Dimers in Polar and Nonpolar Solvents†

2006 ◽  
Vol 110 (38) ◽  
pp. 18965-18972 ◽  
Author(s):  
Ekta Khurana ◽  
Steven O. Nielsen ◽  
Bernd Ensing ◽  
Michael L. Klein
Keyword(s):  
Molecular Dynamics ◽  
Cyclic Peptides ◽  
Nonpolar Solvents ◽  
Self Assembling

scholarly journals Stability and growth mechanism of self-assembling putative antifreeze cyclic peptides

2017 ◽  
Vol 19 (29) ◽  
pp. 19032-19042 ◽  
Author(s):  
Z. Faidon Brotzakis ◽  
Mascha Gehre ◽  
Ilja K. Voets ◽  
Peter G. Bolhuis
Keyword(s):  
Growth Mechanism ◽  
Cyclic Peptides ◽  
Cyclic Peptide ◽  
Growth Mechanisms ◽  
Self Assembling ◽  
Peptide Nanotube ◽  
Cyclic Peptide Nanotube

From right to left: three distinct growth mechanisms of a pentamer to a hexamer putative antifreeze cyclic peptide nanotube.

scholarly journals New self-assembling peptide nanotubes of large diameter using δ-amino acids

2018 ◽  
Vol 9 (43) ◽  
pp. 8228-8233 ◽  
Author(s):  
Alejandro Lamas ◽  
Arcadio Guerra ◽  
Manuel Amorín ◽  
Juan R. Granja
Keyword(s):  
Amino Acids ◽  
Building Block ◽  
Cyclic Peptides ◽  
Large Diameter ◽  
Peptide Nanotubes ◽  
Self Assembling ◽  
Aminocyclohexanecarboxylic Acid

Here we show that 4-aminocyclohexanecarboxylic acid is a rigid stretcher building block for the preparation of cyclic peptides that self-assemble to form peptide nanotubes with large diameter and hydrophobic pores.

scholarly journals Systematic study of the structural parameters affecting the self-assembly of cyclic peptide–poly(ethylene glycol) conjugates

Soft Matter ◽  
2018 ◽  
Vol 14 (30) ◽  
pp. 6320-6326 ◽  
Author(s):  
Edward D. H. Mansfield ◽  
Matthias Hartlieb ◽  
Sylvain Catrouillet ◽  
Julia Y. Rho ◽  
Sophie C. Larnaudie ◽  
...  
Keyword(s):  
Amino Acids ◽  
Self Assembly ◽  
Cyclic Peptides ◽  
Cyclic Peptide ◽  
Hydrophobic Interactions ◽  
Structural Parameters ◽  
The Self ◽  
Poly Ethylene Glycol ◽  
Self Assembling ◽  
Poly Ethylene

Self-assembling cyclic peptides (CP) consisting of amino acids with alternating d- and l-chirality form nanotubes by hydrogen bonding, hydrophobic interactions, and π–π stacking in solution.

Liquid crystal organization of self-assembling cyclic peptides

2014 ◽  
Vol 50 (6) ◽  
pp. 688-690 ◽  
Author(s):  
Manuel Amorín ◽  
Ana Pérez ◽  
Joaquín Barberá ◽  
Haxel Lionel Ozores ◽  
José Luis Serrano ◽  
...  
Keyword(s):  
Liquid Crystal ◽  
Cyclic Peptides ◽  
Self Assembling

Self-assembling properties of all γ-cyclic peptides containing sugar amino acid residues

2012 ◽  
Vol 10 (44) ◽  
pp. 8762 ◽  
Author(s):  
Arcadio Guerra ◽  
Roberto J. Brea ◽  
Manuel Amorín ◽  
Luis Castedo ◽  
Juan R. Granja
Keyword(s):  
Amino Acid ◽  
Cyclic Peptides ◽  
Amino Acid Residues ◽  
Self Assembling

scholarly journals Self-assembling α,γ-cyclic peptides that generate cavities with tunable properties

2016 ◽  
Vol 7 (1) ◽  
pp. 183-187 ◽  
Author(s):  
Nuria Rodríguez-Vázquez ◽  
Rebeca García-Fandiño ◽  
Manuel Amorín ◽  
Juan R. Granja
Keyword(s):  
Cyclic Peptides ◽  
Design And Synthesis ◽  
Self Assembling ◽  
Tunable Properties

The design and synthesis of self-assembling cyclic peptides with tunable cavity properties is described, allowing the incorporation of guests with different features.

scholarly journals Transmembrane Self-Assembled Cyclic Peptide Nanotubes Based on α‐Residues and Cyclic δ‐Amino Acids: A Computational Study

2021 ◽  
Vol 9 ◽  
Author(s):  
Alexandre Blanco-González ◽  
Martín Calvelo ◽  
Pablo F. Garrido ◽  
Manuel Amorín ◽  
Juan R. Granja ◽  
...  
Keyword(s):  
Amino Acids ◽  
Cyclic Peptides ◽  
Cyclic Peptide ◽  
Computational Study ◽  
Peptide Nanotubes ◽  
Peptide Motifs ◽  
Self Assembling ◽  
Transmembrane Channels ◽  
Dynamics Simulations ◽  
Cyclic Peptide Nanotubes

Self-assembling cyclic peptide nanotubes have been shown to function as synthetic, integral transmembrane channels. The combination of natural and nonnatural aminoacids in the sequence of cyclic peptides enables the control not only of their outer surface but also of the inner cavity behavior and properties, affecting, for instance, their permeability to different molecules including water and ions. Here, a thorough computational study on a new class of self-assembling peptide motifs, in which δ-aminocycloalkanecarboxylic acids are alternated with natural α-amino acids, is presented. The presence of synthetic δ-residues creates hydrophobic regions in these α,δ-SCPNs, which makes them especially attractive for their potential implementation in the design of new drug or diagnostic agent carrier systems. Using molecular dynamics simulations, the behavior of water molecules, different ions (Li+, Na+, K+, Cs+, and Ca2+), and their correspondent counter Cl− anions is extensively investigated in the nanoconfined environment. The structure and dynamics are mutually combined in a diving immersion inside these transmembrane channels to discover a fascinating submarine nanoworld where star-shaped water channels guide the passage of cations and anions therethrough.

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