Effect of Residual Water and Microwave Heating on the Half-Life of the Reagents and Reactive Intermediates in Peptide Synthesis

2012 ◽  
Vol 18 (29) ◽  
pp. 9024-9031 ◽  
Author(s):  
A. Pernille Tofteng ◽  
Søren L. Pedersen ◽  
Dan Staerk ◽  
Knud J. Jensen
Keyword(s):  
Microwave Heating ◽  
Peptide Synthesis ◽  
Half Life ◽  
Reactive Intermediates ◽  
Residual Water

Microwave heating in solid-phase peptide synthesis

2012 ◽  
Vol 41 (5) ◽  
pp. 1826-1844 ◽  
Author(s):  
Søren L. Pedersen ◽  
A. Pernille Tofteng ◽  
Leila Malik ◽  
Knud J. Jensen
Keyword(s):  
Microwave Heating ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis

scholarly journals One-Pot Ring-Opening Peptide Synthesis Using α,α-Difluoro-β-Lactams

Synthesis ◽  
2020 ◽  
Vol 52 (23) ◽  
pp. 3657-3666 ◽  
Author(s):  
Masaaki Omote ◽  
Atsushi Tarui ◽  
Masakazu Ueo ◽  
Marino Morikawa ◽  
Masahiko Tsuta ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Methyl Ester ◽  
Peptide Synthesis ◽  
Ring Opening ◽  
Reactive Intermediates ◽  
One Pot ◽  
Open Chain ◽  
Lactam Ring

α,α-Difluoro-β-lactams successfully underwent ring-opening aminolysis with various amino acids in 2,2,2-trifluoroethanol to afford fluorine-containing peptides. In this aminolysis, it was found that 2,2,2-trifluoroethanol first attacked the α,α-difluoro-β-lactams with cleavage of lactam ring to form the corresponding open-chain 2,2,2-trifluoroethyl esters as reactive intermediates. The trifluoroethyl esters were more electrophilic compared with the corresponding methyl ester and thereby accelerated the aminolysis with various amino acids to form β-amino acid peptides with α,α-difluoromethylene unit.

ChemInform Abstract: Microwave Heating in Solid-Phase Peptide Synthesis

ChemInform ◽  
2012 ◽  
Vol 43 (23) ◽  
pp. no-no
Author(s):  
Soeren L. Pedersen ◽  
A. Pernille Tofteng ◽  
Leila Malik ◽  
Knud J. Jensen
Keyword(s):  
Microwave Heating ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis

Automated ‘X-Y’ robot for peptide synthesis with microwave heating: application to difficult peptide sequences and protein domains

2010 ◽  
Vol 16 (9) ◽  
pp. 506-512 ◽  
Author(s):  
Leila Malik ◽  
A. Pernille Tofteng ◽  
Søren L. Pedersen ◽  
Kasper K. Sørensen ◽  
Knud J. Jensen
Keyword(s):  
Microwave Heating ◽  
Peptide Synthesis ◽  
Protein Domains ◽  
Difficult Peptide Sequences

Reactive Intermediates in Peptide Synthesis:  First Crystal Structures andab InitioCalculations of 2-Alkoxy-5(4H)-oxazolones from Urethane-Protected Amino Acids

1997 ◽  
Vol 119 (18) ◽  
pp. 4136-4142 ◽  
Author(s):  
Marco Crisma ◽  
Giovanni Valle ◽  
Fernando Formaggio ◽  
Claudio Toniolo ◽  
Alessandro Bagno
Keyword(s):  
Amino Acids ◽  
Crystal Structures ◽  
Peptide Synthesis ◽  
Reactive Intermediates

The Half-Life of Mindless Psychology

1991 ◽  
Vol 36 (5) ◽  
pp. 455-455
Author(s):  
Michael J. Mahoney
Keyword(s):  
Half Life
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