Synthesis, Self-Assembling Properties, and Atom Transfer Radical Polymerization of an AlkylatedL-Phenylalanine-Derived Monomeric Organogel from Silica: A New Approach To Prepare Packing Materials for High-Performance Liquid Chromatography

2008 ◽  
Vol 14 (4) ◽  
pp. 1312-1321 ◽  
Author(s):  
M. Mizanur Rahman ◽  
Miklós Czaun ◽  
Makoto Takafuji ◽  
Hirotaka Ihara
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
High Performance ◽  
Atom Transfer ◽  
Packing Materials ◽  
New Approach ◽  
Self Assembling

Ionic liquid as porogen in the preparation of a polymer-based monolith for the separation of protein by high performance liquid chromatography

2015 ◽  
Vol 7 (2) ◽  
pp. 607-613 ◽  
Author(s):  
Ligai Bai ◽  
Jiafei Wang ◽  
Hang Zhang ◽  
Sha Liu ◽  
Junxiao Qin ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
High Performance ◽  
Atom Transfer

A novel polymer-based monolith for high performance liquid chromatography was developed by atom transfer radical polymerization (without the expensive complexing ligand) in which the ionic liquid (1-butyl-3-methylimidazolium chloride) was used as the porogen.

scholarly journals Development of a New Approach for Standardization of the Herb Centaurium erythraea Rafn. by High Performance Liquid Chromatography

2020 ◽  
Vol 17 (6) ◽  
pp. 593-598
Author(s):  
Svitlana M. GUBAR ◽  
Anna S. MATERIIENKO ◽  
Nataliia M. SMIELOVA ◽  
Liana G. BUDANOVA ◽  
Victoriya A. GEORGIYANTS
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
New Approach ◽  
Centaurium Erythraea

scholarly journals π-Donor/π-Acceptor Interactions for the Encapsulation of Neurotransmitters on Functionalized Polysilicon-Based Microparticles

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 724
Author(s):  
Sandra Giraldo ◽  
María E. Alea-Reyes ◽  
David Limón ◽  
Asensio González ◽  
Marta Duch ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Cell Line ◽  
High Performance ◽  
Fibroblast Cell ◽  
Mouse Fibroblast ◽  
Liver Carcinoma ◽  
Visible Absorption ◽  
Self Assembling ◽  
Angle Measurements

Bipyridinium salts, commonly known as viologens, are π-acceptor molecules that strongly interact with π-donor compounds, such as porphyrins or amino acids, leading their self-assembling. These properties have promoted us to functionalize polysilicon microparticles with bipyridinium salts for the encapsulation and release of π-donor compounds such as catecholamines and indolamines. In this work, the synthesis and characterization of four gemini-type amphiphilic bipyridinium salts (1·4PF6–4·4PF6), and their immobilization either non-covalently or covalently on polysilicon surfaces and microparticles have been achieved. More importantly, they act as hosts for the subsequent incorporation of π-donor neurotransmitters such as dopamine, serotonin, adrenaline or noradrenaline. Ultraviolet-visible absorption and fluorescence spectroscopies and high-performance liquid chromatography were used to detect the formation of the complex in solution. The immobilization of bipyridinium salts and neurotransmitter incorporation on polysilicon surfaces was corroborated by contact angle measurements. The reduction in the bipyridinium moiety and the subsequent release of the neurotransmitter was achieved using ascorbic acid, or Vitamin C, as a triggering agent. Quantification of neurotransmitter encapsulated and released from the microparticles was performed using high-performance liquid chromatography. The cytotoxicity and genotoxicity studies of the bipyridinium salt 1·4PF6, which was selected for the non-covalent functionalization of the microparticles, demonstrated its low toxicity in the mouse fibroblast cell line (3T3/NIH), the human liver carcinoma cell line (HepG2) and the human epithelial colorectal adenocarcinoma cell line (Caco-2).

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