scholarly journals Does dicamba exposure elicit a hormetic response in sensitive soybean?

cftm ◽  
2021 ◽  
Author(s):  
Mason C Castner ◽  
Jason K Norsworthy ◽  
Tom Barber ◽  
Edward Gbur ◽  
Trenton Roberts
Keyword(s):  
Hormetic Response

scholarly journals Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone

2009 ◽  
Vol 130 (6) ◽  
pp. 357-369 ◽  
Author(s):  
Aaron J. Przybysz ◽  
Keith P. Choe ◽  
L. Jackson Roberts ◽  
Kevin Strange
Keyword(s):  
Caenorhabditis Elegans ◽  
Hormetic Response

Hormesis - Implications for risk assessment caloric intake (body weight) as an exemplar

1998 ◽  
Vol 17 (8) ◽  
pp. 454-459 ◽  
Author(s):  
Angelo Turturro ◽  
Bruce Hass ◽  
Ronald W Hart
Keyword(s):  
Risk Assessment ◽  
Caloric Intake ◽  
Toxicity Testing ◽  
Risk Assessments ◽  
Specific Information ◽  
Response Curves ◽  
Hormetic Effect ◽  
The Impact ◽  
Hormetic Response

Hormesis can be considered as a parameter which has a non-monotonic relationship with some endpoint. Since caloric intake is such a parameter, and the impact of this parameter on risk assessment has been fairly well characterized, it can provide clues as to how to integrate the information from a hormetic parameter into risk assessments for toxicants. Based on the work with caloric intake, one could: (a) define a biomarker for hormetic effect; (b) integrate specific information on when in the animals lifespan the parameter is active to influence parameters such as survival; (c) evaluate component effects of the overall hormetic response; and (d) address the consequences of a non-monotonic relationship between the hormetic parameter and endpoints critical for risk assessment. These impacts on risk assessments have been characterized for chronic tests, but are also true for short-term tests. A priority is the characterization of the dose-response curves for hormetic parameters. This quantification will be critical in utilizing them in risk assessment. With this information, one could better quantitatively address the changes one expects to result from the hormetic parameter, and limit the uncertainty and variability which occurs in toxicity testing.

scholarly journals Hormetic Response to Low-Dose Radiation: Focus on the Immune System and Its Clinical Implications

2017 ◽  
Vol 18 (2) ◽  
pp. 280 ◽  
Author(s):  
Jiuwei Cui ◽  
Guozi Yang ◽  
Zhenyu Pan ◽  
Yuguang Zhao ◽  
Xinyue Liang ◽  
...  
Keyword(s):  
Immune System ◽  
Low Dose ◽  
Clinical Implications ◽  
Low Dose Radiation ◽  
Hormetic Response ◽  
Dose Radiation

Does caloric restriction induce hormesis?

2000 ◽  
Vol 19 (6) ◽  
pp. 320-329 ◽  
Author(s):  
A Turturro ◽  
B S Hass ◽  
R W Hart
Keyword(s):  
Caloric Restriction ◽  
Dose Response ◽  
Nonhuman Primates ◽  
Proliferative Potential ◽  
Response Curves ◽  
Aging Research ◽  
The Impact ◽  
Higher Doses ◽  
Hormetic Response ◽  
Selection Of

The question of whether caloric restriction (CR) is hormetic is addressed in terms of two common defini-tions of the term. In terms of the older definition, i.e., a growth-stimulatory effect when lower doses of a compound which resulted in growth inhibition at higher doses, CR is better characterized as a co-hormetic (i.e., a paradigm which at relatively “low doses,” in combina-tion with some stimulus, will evince increased growth (proliferation) and at higher “doses” will inhibit this increased proliferation) rather than a hormetic agent. Mechanisms such as cellular selection of cellular subpopulations, increases in receptor efficiency, and preservation of cellular proliferative potential can inter-act with agents and produce increased growth as long as the CR is not too severe. In terms of a broader definition, i.e., nonmonotonic dose-response behavior of a compound for any adverse response, CR appears to be hormetic, both as a result of body weight (BW) loss and other potential mechanisms. The impact of changes in BW, or frank CR, can be considered a component of every test for hormesis, and is thus capable for interaction with any other agent. The changes that BW loss (or CR) induce are so profound that any aspect of an agent's action-metabolism, pharmacokinetics, pharmacodynamics-can modulate the response of an organism to an agent. Similarly, other effects of a chemical that induce BW loss, e.g., physical activity or temperature dysregulation, can also induce dose-response curves that appear hormetic. The interaction of the hormetic agents of BW loss and CR can influence agent tests. Controlling these factors may make it possible to dissect the key components of a hormetic response. In addition, the effects of CR or BW loss appear to extrapolate well across species [Colman R, Kemnitz JW. Aging experi-ments using nonhuman primates. In: Yu BP (Ed), Methods in Aging Research. CRC Press, Boca Raton, FL, 1999, pp. 249-267]. Thus there is some reason to believe that these hormetic factors may be important for humans, and may already be a factor for tests of potentially adverse agents already conducted in humans.

scholarly journals Toluene induces hormetic response of soil alkaline phosphatase and the potential enzyme kinetic mechanism

2020 ◽  
Vol 206 ◽  
pp. 111123 ◽  
Author(s):  
Diwu Fan ◽  
Yujing Jing ◽  
Yongli Zhu ◽  
Sajjad Ahmad ◽  
Jiangang Han
Keyword(s):  
Alkaline Phosphatase ◽  
Kinetic Mechanism ◽  
Enzyme Kinetic ◽  
Hormetic Response

Employing multi-omics to elucidate the hormetic response against oxidative stress exerted by nC60 on Daphnia pulex

2019 ◽  
Vol 251 ◽  
pp. 22-29 ◽  
Author(s):  
Pu Wang ◽  
Qin Xiang Ng ◽  
Bo Zhang ◽  
Zhikai Wei ◽  
Muhammad Hassan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Daphnia Pulex ◽  
Hormetic Response

Hormetic response via Nrf2 in mice with a genetic deletion of the antioxidant enzyme NQO1

2012 ◽  
Vol 53 ◽  
pp. S126
Author(s):  
J. Ariza⁎ ◽  
L. Jódar ◽  
E.M. Mercken ◽  
B. Carboneau ◽  
R. de Cabo ◽  
...  
Keyword(s):  
Antioxidant Enzyme ◽  
Genetic Deletion ◽  
Hormetic Response

Commentary on ‘Resveratrol commonly displays hormesis: Occurrence and biomedical significance’

2010 ◽  
Vol 29 (12) ◽  
pp. 1032-1033 ◽  
Author(s):  
Jette F Young ◽  
Sumangala Bhattacharya
Keyword(s):  
Oral Administration ◽  
Matrix Effects ◽  
Disease Models ◽  
Disease Development ◽  
Food Matrix ◽  
Positive Effects ◽  
The Impact ◽  
Lead Article ◽  
Hormetic Response ◽  
French Paradox

The lead article ‘‘Resveratrol commonly displays hormesis: occurrence and biomedical significance’’ underlines the hormetic response of resveratrol in many disease models. This commentary suggests that the greatest potential advantage of the positive effects of resveratrol for the broad population would be as prevention of disease development through oral administration in its original food matrix, although it still remains important to investigate the extent of resveratrol administration giving maximum beneficial effect for biomedical purposes. In relation to resveratrol ‘‘supplementation’’ through its natural environment further investigation of the impact of co-occurring bioactive compounds and matrix effects on hormetic responses of resveratrol is necessary for revealing mechanisms behind e.g. the ‘‘French paradox’’.

scholarly journals Cellular hormetic response to 27-hydroxycholesterol promotes neuroprotection through AICD induction of MAST4 abundance and kinase activity

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Brendan Gongol ◽  
Traci L. Marin ◽  
John D. Jeppson ◽  
Karina Mayagoitia ◽  
Samuel Shin ◽  
...  
Keyword(s):  
Kinase Activity ◽  
Hormetic Response
Sign in / Sign up

Export Citation Format

Share Document