Drop Detachment from a Micro-Engineered Membrane Surface in a Dynamic Membrane Emulsification Process

2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
S. Holzapfel ◽  
E. Rondeau ◽  
P. Mühlich ◽  
E. J. Windhab
Keyword(s):  
Membrane Surface ◽  
Dynamic Membrane ◽  
Membrane Emulsification ◽  
Drop Detachment ◽  
Emulsification Process

scholarly journals Microencapsulation of Enteric Bacteriophages in a pH-Responsive Solid Oral Dosage Formulation Using a Scalable Membrane Emulsification Process

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 475 ◽  
Author(s):  
Vinner ◽  
Richards ◽  
Leppanen ◽  
Sagona ◽  
Malik
Keyword(s):  
Epithelial Cells ◽  
Prolonged Exposure ◽  
Oral Dosage ◽  
Bacterial Cells ◽  
Ph Responsive ◽  
Ion Milling ◽  
Membrane Emulsification ◽  
E Coli ◽  
Emulsification Process

A scalable low-shear membrane emulsification process was used to produce microencapsulated Escherichia coli-phages in a solid oral dosage form. Uniform pH-responsive composite microparticles (mean size ~100 µm) composed of Eudragit® S100 and alginate were produced. The internal microstructure of the gelled microcapsules was studied using ion-milling and imaging, which showed that the microparticles had a solid internal core. The microencapsulation process significantly protected phages upon prolonged exposure to a simulated gastric acidic environment. Encapsulated phages that had been pre-exposed to simulated gastric acid were added to actively growing bacterial cells using in vitro cell cultures and were found to be effective in killing E. coli. Encapsulated phages were also shown to be effective in killing actively growing E. coli in the presence of human epithelial cells. Confocal microscopy images showed that the morphology of encapsulated phage-treated epithelial cells was considerably better than controls without phage treatment. The encapsulated phages were stable during refrigerated storage over a four-week period. The process of membrane emulsification is highly scalable and is a promising route to produce industrial quantities of pH-responsive oral solid dosage forms suitable for delivering high titres of viable phages to the gastrointestinal tract.

scholarly journals Linking Findings in Microfluidics to Membrane Emulsification Process Design: The Importance of Wettability and Component Interactions with Interfaces

Membranes ◽  
2016 ◽  
Vol 6 (2) ◽  
pp. 26 ◽  
Author(s):  
Karin Schroën ◽  
Montse Ferrando ◽  
Silvia de Lamo-Castellví ◽  
Sami Sahin ◽  
Carme Güell
Keyword(s):  
Process Design ◽  
Membrane Emulsification ◽  
Emulsification Process

The membrane emulsification process—a review

2004 ◽  
Vol 79 (3) ◽  
pp. 209-218 ◽  
Author(s):  
C Charcosset ◽  
I Limayem ◽  
H Fessi
Keyword(s):  
Membrane Emulsification ◽  
Emulsification Process

scholarly journals Separation of Oil Emulsion with Dynamic Membrane with Surface Layer of Polystyrene

2021 ◽  
Vol 132 (1) ◽  
pp. 10-14
Author(s):  
D. D. Fazullin ◽  
◽  
G. V. Mavrin ◽  
L. I. Fazullina ◽  
◽  
...  
Keyword(s):  
Surface Layer ◽  
Membrane Separation ◽  
Membrane Surface ◽  
Specific Productivity ◽  
Dispersed Phase ◽  
Retention Capacity ◽  
Dynamic Membrane ◽  
Oil Emulsion ◽  
Membrane Particle ◽  
Oil Particles

In this paper, we studied the parameters of the process of separation of oil emulsion using a dynamic membrane of ultrafiltration PTFEg-PSd. A polymer membrane with a dynamic layer of polystyrene particles with sizes from 55 to 72 nm was obtained on a substrate of hydrophilic polytetrafluoroethylene (PTFE). The results of scanning electron microscopy showed the formation of a layer of spherical polystyrene particles on the membrane surface. The properties of a dynamic membrane were studied: porosity, moisture capacity, and wettability. After applying the polystyrene layer, an increase in the hydrophobicity of the surface layer of the membrane was established. For membrane separation, a 1% oil emulsion was prepared by dispersing the carbonaceous oil. The retention capacity of membranes for oil products from 1% oil emulsion was 96.4%, with a specific productivity of 113 dm3/m2·h which is not inferior to the performance of a commercial UPM-100 ultrafiltration membrane. Particle sizes of the dispersed phase in a 1% oil emulsion are distributed in the range from 229 to 1476 nm, after separation of the emulsion by a dynamic membrane, oil particles with sizes from 134 to 236 nm were detected in the filtrate, which indicates the removal of the bulk of the dispersed phase from the emulsion by ultrafiltration membranes.

scholarly journals Vinaigrette Production by Membrane Emulsification: Process Optimization and Product Development

2015 ◽  
Vol 59 (3) ◽  
pp. 206-208
Author(s):  
Krisztina Albert ◽  
András Koris ◽  
Shabbir Ahammed ◽  
Igor Gáspár ◽  
Gyula Vatai
Keyword(s):  
Product Development ◽  
Process Optimization ◽  
Membrane Emulsification ◽  
Emulsification Process
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