Generation of a Key Synthon of Indole Alkaloid Synthesis by Palladium(II)‐Catalyzed Indole 2‐Methylenephosphorylation

ChemCatChem ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 3644-3649
Author(s):  
Yuan Niu ◽  
Peng‐Bo Bai ◽  
Qin‐Xin Lou ◽  
Shang‐Dong Yang
Keyword(s):  
Indole Alkaloid ◽  
Alkaloid Synthesis

5-Methyltryptophan Resistant Cells of Catharanthus roseus

1979 ◽  
Vol 34 (7-8) ◽  
pp. 541-545 ◽  
Author(s):  
Jürgen Schallenberg ◽  
Jochen Berlin
Keyword(s):  
Catharanthus Roseus ◽  
Indole Alkaloids ◽  
Indole Alkaloid ◽  
Synthetase Activity ◽  
Wild Type ◽  
Free Tryptophan ◽  
Alkaloid Synthesis ◽  
Resistant Cells

Several cell lines resistant to 5-methyltryptophan were selected from wild type cells of different Catharanthus roseus suspension cultures. The resistant cells had up to 30 times tne normal levels of free tryptophan. Despite the increased pool size of tryptophan anthranilate synthetase activity of resistant cells was as sensitive to inhibition by ʟ-tryptophan as wild type cells. The overproduction of tryptophan did not lead to intensified accumulation of tryptamine nor of indole alkaloids. This was supported by a low conversion of tryptophan to tryptamine in vivo and in vitro. The overpro­duction of one of the primary precursors was evidently not sufficient to stimulate the rate of indole alkaloid synthesis in Catharanthus cells.

A Photochemical Approach to Spiranic 2,3-Indolines, Useful Intermediates in Pentacyclic Indole Alkaloid Synthesis

Heterocycles ◽  
1995 ◽  
Vol 41 (9) ◽  
pp. 1939 ◽  
Author(s):  
Marie-Eve Sinibaldi ◽  
Malika Ibrahim-Ouali ◽  
Yves Troin ◽  
Annie Cuer ◽  
Gérard Dauphin ◽  
...  
Keyword(s):  
Indole Alkaloid ◽  
Alkaloid Synthesis

Indole Alkaloid Synthesis

Heterocycles ◽  
1984 ◽  
Vol 21 (1) ◽  
pp. 325 ◽  
Author(s):  
Ernest Wenkert
Keyword(s):  
Indole Alkaloid ◽  
Alkaloid Synthesis
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