An Efficient Mesoporous Cu‐Organic Nanorod for Friedländer Synthesis of Quinoline and Click Reactions

ChemCatChem ◽  
2019 ◽  
Vol 11 (17) ◽  
pp. 4340-4350 ◽  
Author(s):  
Samaraj Elavarasan ◽  
Asim Bhaumik ◽  
Manickam Sasidharan
Keyword(s):  
Click Reactions ◽  
Friedlander Synthesis

Click Reactions in Chemistry of Triterpenes - Advances Towards Development of Potential Therapeutics

2018 ◽  
Vol 25 (5) ◽  
pp. 636-658 ◽  
Author(s):  
Jan Pokorny ◽  
Lucie Borkova ◽  
Milan Urban
Keyword(s):  
Biological Activities ◽  
Synthetic Approach ◽  
Clinical Use ◽  
New Approach ◽  
Click Reactions ◽  
Drug Candidates ◽  
The Past ◽  
Low Toxicity ◽  
New Compounds ◽  
Potential Therapeutics

Triterpenoids are natural compounds with a large variety of biological activities such as anticancer, antiviral, antibacterial, antifungal, antiparazitic, antiinflammatory and others. Despite their low toxicity and simple availability from the natural resources, their clinical use is still severely limited by their higher IC50 and worse pharmacological properties than in the currently used therapeutics. This fact encouraged a number of researchers to develop new terpenic derivatives more suitable for the potential clinical use. This review summarizes a new approach to improve both, the activity and ADME-Tox properties by connecting active terpenes to another modifying molecules using click reactions. Within the past few years, this synthetic approach was well explored yielding a lot of great improvements of the parent compounds along with some less successful attempts. A large quantity of the new compounds presented here are superior in both activity and ADME-Tox properties to their parents. This review should serve the researchers who need to promote their hit triterpenic structures towards their clinical use and it is intended as a guide for the chemical synthesis of better drug candidates.

Friedländer Synthesis of Novel Polycyclic Quinolines Using Solid SiO2/H2SO4 Catalyst

2021 ◽  
pp. 1-7
Author(s):  
Rajendran Satheeshkumar ◽  
Krishnamoorthy Shanmugaraj ◽  
Thalia Delgado ◽  
Jeanluc Bertrand ◽  
Iván Brito ◽  
...  
Keyword(s):  
Friedlander Synthesis

Dendronized polystyrene via orthogonal double-click reactions

2013 ◽  
Vol 51 (23) ◽  
pp. 5029-5037 ◽  
Author(s):  
Murat Tonga ◽  
Gulen Yesilbag Tonga ◽  
Gonca Seber ◽  
Ozgul Gok ◽  
Amitav Sanyal
Keyword(s):  
Click Reactions

Functionalized resorcin[4]arene-based coordination polymers as heterogeneous catalysts for click reactions

2021 ◽  
Vol 45 (6) ◽  
pp. 3181-3187
Author(s):  
Fei-Fei Wang ◽  
Jia-Hui Li ◽  
Hai-Yan Liu ◽  
Shu-Ping Deng ◽  
Ying-Ying Liu ◽  
...  
Keyword(s):  
Coordination Polymers ◽  
Heterogeneous Catalysts ◽  
Click Reactions

One Cu(i) and two Cd(ii) coordination polymers have been achieved using a 4-mercaptopyridine-functionalized resorcin[4]arene. 1 exhibits predominant efficiency and excellent recyclability for the synthesis of 1,2,3-triazoles and β-OH-1,2,3-triazoles.

A Comparative Study of Thiol-Terminated Surface Modification by Click Reactions: Thiol-yne Coupling versus Thiol-ene Michael Addition

2018 ◽  
Vol 5 (24) ◽  
pp. 1801343 ◽  
Author(s):  
Seyed Mohammad Mahdi Dadfar ◽  
Sylwia Sekula-Neuner ◽  
Vanessa Trouillet ◽  
Michael Hirtz
Keyword(s):  
Surface Modification ◽  
Comparative Study ◽  
Michael Addition ◽  
Click Reactions

A New Green Approach to the Friedländer Synthesis of Quinolines

Synlett ◽  
2003 ◽  
pp. 0203-0206 ◽  
Author(s):  
Antonio Arcadi ◽  
Marco Chiarini ◽  
Sabrina Di Giuseppe ◽  
Fabio Marinelli
Keyword(s):  
Green Approach ◽  
Friedlander Synthesis

Multiarm star triblock terpolymers via sequential double click reactions

2010 ◽  
Vol 48 (7) ◽  
pp. 1557-1564 ◽  
Author(s):  
Hakan Durmaz ◽  
Aydan Dag ◽  
Duygu Gursoy ◽  
A. Levent Demirel ◽  
Gurkan Hizal ◽  
...  
Keyword(s):  
Click Reactions ◽  
Triblock Terpolymers

ChemInform Abstract: Copper(I) 1,2,3-Triazol-5-ylidene Complexes as Efficient Catalysts for Click Reactions of Azides with Alkynes.

ChemInform ◽  
2011 ◽  
Vol 42 (21) ◽  
pp. no-no
Author(s):  
Tatsuhito Nakamura ◽  
Takahiro Terashima ◽  
Kenichi Ogata ◽  
Shin-ichi Fukuzawa
Keyword(s):  
Click Reactions
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