Multiarm star triblock terpolymers via sequential double click reactions

2010 ◽  
Vol 48 (7) ◽  
pp. 1557-1564 ◽  
Author(s):  
Hakan Durmaz ◽  
Aydan Dag ◽  
Duygu Gursoy ◽  
A. Levent Demirel ◽  
Gurkan Hizal ◽  
...  
Keyword(s):  
Click Reactions ◽  
Triblock Terpolymers

Click Reactions in Chemistry of Triterpenes - Advances Towards Development of Potential Therapeutics

2018 ◽  
Vol 25 (5) ◽  
pp. 636-658 ◽  
Author(s):  
Jan Pokorny ◽  
Lucie Borkova ◽  
Milan Urban
Keyword(s):  
Biological Activities ◽  
Synthetic Approach ◽  
Clinical Use ◽  
New Approach ◽  
Click Reactions ◽  
Drug Candidates ◽  
The Past ◽  
Low Toxicity ◽  
New Compounds ◽  
Potential Therapeutics

Triterpenoids are natural compounds with a large variety of biological activities such as anticancer, antiviral, antibacterial, antifungal, antiparazitic, antiinflammatory and others. Despite their low toxicity and simple availability from the natural resources, their clinical use is still severely limited by their higher IC50 and worse pharmacological properties than in the currently used therapeutics. This fact encouraged a number of researchers to develop new terpenic derivatives more suitable for the potential clinical use. This review summarizes a new approach to improve both, the activity and ADME-Tox properties by connecting active terpenes to another modifying molecules using click reactions. Within the past few years, this synthetic approach was well explored yielding a lot of great improvements of the parent compounds along with some less successful attempts. A large quantity of the new compounds presented here are superior in both activity and ADME-Tox properties to their parents. This review should serve the researchers who need to promote their hit triterpenic structures towards their clinical use and it is intended as a guide for the chemical synthesis of better drug candidates.

Dendronized polystyrene via orthogonal double-click reactions

2013 ◽  
Vol 51 (23) ◽  
pp. 5029-5037 ◽  
Author(s):  
Murat Tonga ◽  
Gulen Yesilbag Tonga ◽  
Gonca Seber ◽  
Ozgul Gok ◽  
Amitav Sanyal
Keyword(s):  
Click Reactions

Functionalized resorcin[4]arene-based coordination polymers as heterogeneous catalysts for click reactions

2021 ◽  
Vol 45 (6) ◽  
pp. 3181-3187
Author(s):  
Fei-Fei Wang ◽  
Jia-Hui Li ◽  
Hai-Yan Liu ◽  
Shu-Ping Deng ◽  
Ying-Ying Liu ◽  
...  
Keyword(s):  
Coordination Polymers ◽  
Heterogeneous Catalysts ◽  
Click Reactions

One Cu(i) and two Cd(ii) coordination polymers have been achieved using a 4-mercaptopyridine-functionalized resorcin[4]arene. 1 exhibits predominant efficiency and excellent recyclability for the synthesis of 1,2,3-triazoles and β-OH-1,2,3-triazoles.

A Comparative Study of Thiol-Terminated Surface Modification by Click Reactions: Thiol-yne Coupling versus Thiol-ene Michael Addition

2018 ◽  
Vol 5 (24) ◽  
pp. 1801343 ◽  
Author(s):  
Seyed Mohammad Mahdi Dadfar ◽  
Sylwia Sekula-Neuner ◽  
Vanessa Trouillet ◽  
Michael Hirtz
Keyword(s):  
Surface Modification ◽  
Comparative Study ◽  
Michael Addition ◽  
Click Reactions

Microphase separation and crystallization behaviors of bi-phased triblock terpolymers with a competitively dissolved middle block

Polymer ◽  
2017 ◽  
Vol 117 ◽  
pp. 140-149 ◽  
Author(s):  
Rui-Yang Wang ◽  
Xiang-Yue Wang ◽  
Bin Fan ◽  
Jun-Ting Xu ◽  
Zhi-Qiang Fan
Keyword(s):  
Microphase Separation ◽  
Crystallization Behaviors ◽  
Triblock Terpolymers

ChemInform Abstract: Copper(I) 1,2,3-Triazol-5-ylidene Complexes as Efficient Catalysts for Click Reactions of Azides with Alkynes.

ChemInform ◽  
2011 ◽  
Vol 42 (21) ◽  
pp. no-no
Author(s):  
Tatsuhito Nakamura ◽  
Takahiro Terashima ◽  
Kenichi Ogata ◽  
Shin-ichi Fukuzawa
Keyword(s):  
Click Reactions

Maximizing Conversion of Surface Click Reactions for Versatile Molecular Modification on Metal Oxide Nanowires

Langmuir ◽  
2021 ◽  
Vol 37 (17) ◽  
pp. 5172-5179
Author(s):  
Rimon Yamaguchi ◽  
Takuro Hosomi ◽  
Masaya Otani ◽  
Kazuki Nagashima ◽  
Tsunaki Takahashi ◽  
...  
Keyword(s):  
Metal Oxide ◽  
Click Reactions ◽  
Oxide Nanowires ◽  
Molecular Modification ◽  
Metal Oxide Nanowires

Thiol-Ene “Click Reactions” as a Promising Approach to Polymer Materials

2021 ◽  
Author(s):  
D. S. Kazybayeva ◽  
G. S. Irmukhametova ◽  
V. V. Khutoryanskiy
Keyword(s):  
Polymer Materials ◽  
Click Reactions
Sign in / Sign up

Export Citation Format

Share Document