Recent Progress in Metal Catalyzed Direct Carboxylation of Aryl Halides and Pseudo Halides Employing CO2: Opportunities for11C Radiochemistry

ChemCatChem ◽  
2016 ◽  
Vol 8 (24) ◽  
pp. 3692-3700 ◽  
Author(s):  
Muneer Ahamed ◽  
Joost Verbeek ◽  
Uta Funke ◽  
Joan Lecina ◽  
Alfons Verbruggen ◽  
...  
Keyword(s):  
Recent Progress ◽  
Aryl Halides ◽  
Pseudo Halides ◽  
Metal Catalyzed

Toward the total synthesis of lophotoxin — New methodologies and synthetic strategies

2006 ◽  
Vol 84 (10) ◽  
pp. 1226-1241 ◽  
Author(s):  
Peter Wipf ◽  
Michel Grenon
Keyword(s):  
Transition Metal ◽  
Total Synthesis ◽  
Recent Progress ◽  
Furan Ring ◽  
Addition Reaction ◽  
Thermal Conditions ◽  
Preliminary Results ◽  
Keto Esters ◽  
New Methodologies ◽  
Metal Catalyzed

Our recent progress toward the synthesis of the furanocembranolide lophotoxin (1) is disclosed. Strategies for the stereoselective incorporation of the C13 stereocenter by a catalytic desymmetrization of a cyclic meso-anhydride, as well as a novel 1,6-addition reaction of organocuprates to unsaturated [1,3]dioxin-4-ones are discussed. Preliminary results on the development of a rhodium-catalyzed asymmetric 1,6-addition reaction are also mentioned. Finally, modifications of a previously reported transition-metal-catalyzed cyclization reaction involving α-propargyl β-keto esters allow furan ring formation either under thermal conditions or by microwave irradiation.Key words: 1,6-addition, organocuprates, catalytic desymmetrization, furan cyclization, microwave.

scholarly journals Synthesis of Polyhedral Borane Cluster Fused Heterocycles via Transition Metal Catalyzed B-H Activation

Molecules ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 391 ◽  
Author(s):  
Ke Cao ◽  
Cai-Yan Zhang ◽  
Tao-Tao Xu ◽  
Ji Wu ◽  
Xin-Yu Wen ◽  
...  
Keyword(s):  
Transition Metal ◽  
Recent Progress ◽  
Building Blocks ◽  
Bioactive Natural Products ◽  
Fused Heterocycles ◽  
Selective Functionalization ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed ◽  
Photoluminescent Materials ◽  
Borane Cluster

Aromatic heterocycles are ubiquitous building blocks in bioactive natural products, pharmaceutical and agrochemical industries. Accordingly, the carborane-fused heterocycles would be potential candidates in drug discovery, nanomaterials, metallacarboranes, as well as photoluminescent materials. In recent years, the transition metal catalyzed B-H activation has been proved to be an effective protocol for selective functionalization of B-H bond of o-carboranes, which has been further extended for the synthesis of polyhedral borane cluster-fused heterocycles via cascade B-H functionalization/annulation process. This article summarizes the recent progress in construction of polyhedral borane cluster-fused heterocycles via B-H activation.

Recent Progress in Methylation of (Hetero)Arenes by Cross-Coupling or C–H Activation

Synlett ◽  
2018 ◽  
Vol 29 (04) ◽  
pp. 375-382 ◽  
Author(s):  
Yahu Liu ◽  
Xuebin Liao ◽  
Lu Hu
Keyword(s):  
Recent Progress ◽  
Cross Coupling ◽  
Structure Activity Relationship ◽  
Biological Properties ◽  
Aryl Halides ◽  
Lead Optimization ◽  
Activity Relationship ◽  
Research Groups ◽  
Structure Activity ◽  
Methyl Effect

Owing to the ‘magic methyl effect’ on a compound’s physical and biological properties, methylation is a strategy frequently used by medicinal chemists in structure–activity relationship studies or in lead optimization. This article highlights the most recent reported methods for the direct methylation of (hetero)arenes, which mainly involve either C–H functionalization or cross-coupling of methylating reagents with (hetero)aryl halides. Methylation of C–H bonds of (hetero)-arenes, which is atom economical, has been explored by several research groups in recent years. Given the unmatchable availability of (hetero)aryl halides, we believe that Ni-catalyzed methylation using iodomethane or deuterated iodomethane as the methyl source is one of the most convenient methods.

Recent progress in transition-metal-catalyzed hydrocyanation of nonpolar alkenes and alkynes

2020 ◽  
Vol 18 (3) ◽  
pp. 391-399 ◽  
Author(s):  
Hongru Zhang ◽  
Xin Su ◽  
Kaiwu Dong
Keyword(s):  
Transition Metal ◽  
Recent Progress ◽  
Building Blocks ◽  
Powerful Method ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Hydrocyanation is a powerful method for the preparation of nitriles which are versatile building blocks for the synthesis of amines, acids and amides.

Chromium-Catalyzed Cross-Couplings and Related Reactions

Synthesis ◽  
2019 ◽  
Vol 51 (10) ◽  
pp. 2100-2106 ◽  
Author(s):  
Jie Li ◽  
Paul Knochel
Keyword(s):  
Transition Metal ◽  
Recent Progress ◽  
Short Review ◽  
High Price ◽  
Nickel Catalysis ◽  
Catalytic Reactivity ◽  
Transition Metal Catalyzed ◽  
Low Valent ◽  
Metal Catalyzed ◽  
Remarkable Progress

Transition-metal-catalyzed cross-couplings have been recognized as a powerful tool for sustainable syntheses. Despite the fact that remarkable progress was achieved by palladium and nickel catalysis, the high price and toxicity still remained a drawback. Recently, naturally more abundant and less toxic low-valent chromium salts, such as Cr(II) and Cr(III) chlorides, displayed notable unique catalytic reactivity. Thus, recent progress in the field of chromium-catalyzed cross-couplings and related reactions are highlighted in the present short review until December­ 2018.1 Introduction and Early Chromium-Mediated Reactions2 Chromium-Catalyzed Cross-Couplings and Related Reactions3 Conclusion

Recent advances in the transition metal catalyzed carbonylation of alkynes, arenes and aryl halides using CO surrogates

2015 ◽  
Vol 5 (10) ◽  
pp. 4663-4702 ◽  
Author(s):  
Prashant Gautam ◽  
Bhalchandra M. Bhanage
Keyword(s):  
Carbon Monoxide ◽  
Transition Metal ◽  
Organic Synthesis ◽  
Aryl Halides ◽  
Industrial Synthesis ◽  
Recent Advances ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed ◽  
Important Position

Transition metal catalyzed carbonylation reactions using carbon monoxide as the C-1 source have occupied an all important position in catalysis which is subsequently related to organic synthesis and industrial synthesis of molecules.

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