scholarly journals Knowledge of cytogenetic analysis for synovial sarcoma in sarcomatoid variant renal cell carcinoma

2021 ◽  
Vol 9 (11) ◽  
Author(s):  
Vishal Farid Raza ◽  
Dawood Arshad ◽  
Khalid Irshad ◽  
Khalid Javeed Khan
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Synovial Sarcoma ◽  
Renal Cell ◽  
Cytogenetic Analysis

Primary Renal Synovial Sarcoma Confirmed by Cytogenetic Analysis: A Lesion Distinct From Sarcomatoid Renal Cell Carcinoma

2005 ◽  
Vol 129 (2) ◽  
pp. 238-240 ◽  
Author(s):  
Beverley A. Shannon ◽  
Ashleigh Murch ◽  
Ronald J. Cohen
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Synovial Sarcoma ◽  
Renal Cell ◽  
Cytogenetic Analysis ◽  
Chromosomal Abnormalities ◽  
Fusion Transcript ◽  
Chromosomal Anomalies ◽  
Tumor Type ◽  
Sarcomatoid Renal Cell Carcinoma

Abstract Primary synovial sarcoma rarely originates in the renal parenchyma. When this occurs, origin of this unusual tumor type has been the subject of debate in the literature, with a suggestion that previously reported cases may be more correctly described as renal cell carcinoma with sarcomatoid dedifferentiation. Synovial sarcoma and sarcomatoid renal cell carcinoma may be indistinguishable on pure histologic and immunohistochemical grounds, but these tumors contain distinctly different sets of chromosomal abnormalities. Most previous cases of primary renal synovial sarcoma were confirmed by molecular biology techniques, which detected the SYT-SSX gene fusion transcript typical of this tumor, but no details of the other chromosomal anomalies have been published. We report a case of primary renal synovial sarcoma confirmed by standard cytogenetic analysis, showing the characteristic t(X; 18)(p11.2:q11.2) translocation and other chromosomal aberrations that are typical of synovial sarcoma as opposed to sarcomatoid renal cell carcinoma.

scholarly journals The correlation between gain of chromosome 8q and survival in patients with clear and papillary renal cell carcinoma

2017 ◽  
Vol 10 (1) ◽  
pp. 3-10 ◽  
Author(s):  
Reza Mehrazin ◽  
Essel Dulaimi ◽  
Robert G. Uzzo ◽  
Karthik Devarjan ◽  
Jianming Pei ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cytogenetic Analysis ◽  
Proportional Hazards ◽  
Proportional Hazards Model ◽  
Cox Proportional Hazards ◽  
Cox Proportional Hazards Model ◽  
Renal Tumors ◽  
Rank Test

Background: The proto-oncogene c-MYC, located on chromosome 8q, can be upregulated through gain of 8q, causing alteration in biology of renal cell carcinoma (RCC). The aim of this study was to evaluate the prevalence of c-MYC through chromosome 8q gain and to correlate findings with cancer-specific mortality (CSM), and overall survival (OS). Methods: Cytogenetic analysis by conventional or Chromosomal Genomic Microarray Analysis (CMA) was performed on 414 renal tumors. Nonclear and nonpapillary RCC were excluded. Impact of gain in chromosome 8q status on CSM, OS, and its correlation with clinicopathological variables were evaluated. CSM and OS were assessed using log-rank test and the Cox proportional hazards model. Results: A total of 297 RCC tumors with cytogenetic analysis were included. Gain of 8q was detected in 18 (6.1%) tumors (9 clear cell and 9 papillary RCC), using conventional method ( n = 11) or CMA ( n = 7). Gain of 8q was associated with higher T stage ( p < 0.001), grade ( p < 0.001), nodal involvement ( p = 0.005), and distant metastasis ( p < 0.001). No association between gain of 8q and age ( p = 0.23), sex ( p = 0.46), and Charlson comorbidity index (CCI, p = 0.59) were seen. Gain of 8q was associated with an 8.38-fold [95% confidence interval (CI), 3.83–18.34, p < 0.001] and 3.31-fold (95% CI, 1.56–7.04, p = 0.001) increase in CSM and decrease in OS, respectively, at a median follow up of 56 months. Conclusion: Chromosome 8q harbors the proto-oncogene c-MYC, which can be upregulated by gain of 8q. Our findings suggest that gain of 8q, can predict aggressive tumor phenotype and inferior survival in RCC.

Molecular cytogenetic analysis of clustered sporadic and familial renal cell carcinoma-associated 3q13∼q22 breakpoints

2002 ◽  
Vol 136 (2) ◽  
pp. 95-100 ◽  
Author(s):  
Daniëlle Bodmer ◽  
Irene Janssen ◽  
Yvonne Jonkers ◽  
Eva van den Berg ◽  
Trijnie Dijkhuizen ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cytogenetic Analysis ◽  
Molecular Cytogenetic

scholarly journals Diagnostic journey of a primary renal synovial sarcoma

2021 ◽  
Author(s):  
Vishal Raza ◽  
Dawood Arshad ◽  
Khalid Irshad ◽  
Khalid Khan
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Synovial Sarcoma ◽  
Renal Cell ◽  
Middle Aged ◽  
Work Up

A middle aged female presented with a large flank mass, was initially reported to be a renal cell carcinoma of the sarcomatoid variant. Discordant presentation lead to further pathological work-up and a primary renal synovial sarcoma was diagnosed. We present our journey in images.

1253: Different Survival in PT3A Renal Cell Carcinoma with Sinus Fat Invasion or Perinephric Fat Invasion

2007 ◽  
Vol 177 (4S) ◽  
pp. 413-413
Author(s):  
Marco Roscigno ◽  
Roberto Bertini ◽  
Cesare Cozzarini ◽  
Alessandra Pasta ◽  
Mattia Sangalli ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Perinephric Fat

1252: Relative Survival Following Treatment for Renal Cell Carcinoma (RCC)- A S.E.E.R. Analysis: Is Age Important?

2007 ◽  
Vol 177 (4S) ◽  
pp. 413-413
Author(s):  
Yu-Ning Wong ◽  
Brian L. Egleston ◽  
Ismail R. Saad ◽  
Robert G. Uzzo
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Relative Survival

920: Pediatric Renal Cell Carcinoma: An Aggressive Tumor with Biologic Features Distinct From Its Adult Counterpart

2007 ◽  
Vol 177 (4S) ◽  
pp. 305-305
Author(s):  
Richard A. Ashley ◽  
Jonathan C. Routh ◽  
Sameer A. Siddiqui ◽  
Brant A. Inman ◽  
Thomas J. Sebo ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Pediatric Renal Cell Carcinoma ◽  
Aggressive Tumor
Sign in / Sign up

Export Citation Format

Share Document