scholarly journals A case of metastatic NUT carcinoma with prolonged response on gemcitabine and nab‐paclitaxel

2021 ◽  
Vol 9 (8) ◽  
Author(s):  
Shetal A. Patel ◽  
Bart Singer ◽  
Colette Shen ◽  
Adam M. Zanation ◽  
Wendell G. Yarbrough ◽  
...  
Keyword(s):  
Nut Carcinoma ◽  
Prolonged Response

scholarly journals Challenging Diagnosis in NUT Carcinoma

2021 ◽  
pp. 106689692110195
Author(s):  
Grosse Claudia ◽  
Grosse Alexandra
Keyword(s):  
Nuclear Protein ◽  
Hematological Malignancy ◽  
Undifferentiated Carcinoma ◽  
Squamous Differentiation ◽  
Poorly Differentiated Carcinoma ◽  
Poorly Differentiated ◽  
Nut Carcinoma ◽  
Disseminated Disease ◽  
Generation Sequencing

Nuclear protein in testis (NUT) carcinoma represents a highly aggressive, poorly differentiated carcinoma that is genetically defined by rearrangement of NUT gene. The histomorphological appearance ranges from entirely undifferentiated carcinoma to carcinoma with prominent squamous differentiation. NUT carcinoma can display neuroendocrine features. Although it is typically distributed along the midline axis, it may manifest in nonmidline locations. The majority of patients develop rapidly disseminated disease. We illustrate 2 cases of NUT carcinoma, one located in the lung, which closely resembled a neuroendocrine carcinoma, and the other one with assumed lung origin demonstrating metastatic dissemination with diffuse bone involvement, which was clinically first suspected to be a hematological malignancy. Due to its undifferentiated nature, NUT carcinoma may be confused with many entities. NUT immunohistochemistry is considered to be sufficient for the diagnosis. Fluorescence in-situ hybridization analysis and next-generation sequencing are currently used to confirm the diagnosis.

Prolonged response of skeletal muscle in the absence of penetrating anions

1960 ◽  
Vol 198 (2) ◽  
pp. 289-299 ◽  
Author(s):  
Gertrude Falk ◽  
Jorge F. Landa
Keyword(s):  
Action Potentials ◽  
Critical Concentration ◽  
Relaxation Oscillations ◽  
Plateau Phase ◽  
Slow Oscillations ◽  
Mechanical Responses ◽  
External Potassium ◽  
Prolonged Response ◽  
Plateau Level ◽  
Potassium Addition

Replacement of Ringer's chloride by a variety of nonpenetrating anions results in prolonged electrical and mechanical responses of muscle to stimulation. The ‘negative after-potential’ is characterized by a slowly increasing secondary depolarization which reaches a stable plateau lasting as long as 2 minutes. After-discharge frequently occurs during early depolarization. In most fibers repolarization is relatively abrupt, but in some, slow oscillations resembling relaxation oscillations arise following the plateau, grow gradually in amplitude and, only when they are of sufficient amplitude, does the membrane repolarize. Prolonged depolarization can still be produced when the spike has failed. At times, fibers may respond with short-duration action potentials, but may be primed to give prolonged responses by previous stimuli or by increase of external potassium. Addition of chloride has no effect below a critical concentration. Reduction of sodium to 25% of normal does not change plateau level or duration. Duration of the plateau phase is decreased by potassium.

scholarly journals Challenges and Opportunities in NUT Carcinoma Research

Genes ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 235
Author(s):  
Bin Gu ◽  
Maxwell C. Hakun
Keyword(s):  
Cell Biology ◽  
Current Knowledge ◽  
Short Review ◽  
Specific Protein ◽  
Cell Of Origin ◽  
Chromosome Translocations ◽  
Very Young Children ◽  
Aggressive Cancer ◽  
Challenges And Opportunities ◽  
Nut Carcinoma

NUT carcinoma (NC) is a type of aggressive cancer driven by chromosome translocations. Fusion genes between a DNA-binding protein, such as bromodomain and extraterminal domain (BET) proteins, and the testis-specific protein NUTM1 generated by these translocations drive the formation of NC. NC can develop in very young children without significant accumulation of somatic mutations, presenting a relatively clean model to study the genetic etiology of oncogenesis. However, after 20 years of research, a few challenging questions still remain for understanding the mechanism and developing therapeutics for NC. In this short review, we first briefly summarize the current knowledge regarding the molecular mechanism and targeted therapy development of NC. We then raise three challenging questions: (1) What is the cell of origin of NC? (2) How does the germline analogous epigenetic reprogramming process driven by the BET-NUTM1 fusion proteins cause NC? and (3) How will BET-NUTM1 targeted therapies be developed? We propose that with the unprecedented technological advancements in genome editing, animal models, stem cell biology, organoids, and chemical biology, we have unique opportunities to address these challenges.

Cutaneous Primary NUT Carcinoma With BRD3-NUTM1 Fusion

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Yuuki Nishimura ◽  
Eijitsu Ryo ◽  
Naoya Yamazaki ◽  
Yasushi Yatabe ◽  
Taisuke Mori
Keyword(s):  
Nut Carcinoma

Prolonged response to sorafenib in a patient with refractory metastatic osteosarcoma and a somatic PDGFRA D846V mutation

2018 ◽  
Vol 66 (1) ◽  
pp. e27493 ◽  
Author(s):  
Amy E. Armstrong ◽  
David O. Walterhouse ◽  
Patrick J. Leavey ◽  
Jennifer Reichek ◽  
Amy L. Walz
Keyword(s):  
Metastatic Osteosarcoma ◽  
Prolonged Response

Renal NUT carcinoma: a case report

2017 ◽  
Vol 72 (3) ◽  
pp. 528-530 ◽  
Author(s):  
Deepika Sirohi ◽  
Karuna Garg ◽  
Jeffry P Simko ◽  
James P Grenert
Keyword(s):  
Case Report ◽  
Nut Carcinoma

scholarly journals NUT carcinoma of the nasal cavity that responded to a chemotherapy regimen for Ewing’s sarcoma family of tumors: a case report

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Kohei Arimizu ◽  
Gen Hirano ◽  
Chinatsu Makiyama ◽  
Mioko Matsuo ◽  
Takakazu Sasaguri ◽  
...  
Keyword(s):  
Case Report ◽  
Nasal Cavity ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Chemotherapy Regimen ◽  
Nut Carcinoma
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