scholarly journals Inappropriate prescription of corticosteroid therapy during inflammatory ileo‐colitis revealing disseminated tuberculosis with digestive involvement: Two case reports

2021 ◽  
Vol 9 (6) ◽  
Author(s):  
Chantelli Iamblaudiot Razafindrazoto ◽  
Nitah Harivony Randriamifidy ◽  
Jolivet Auguste Rakotomalala ◽  
Behoavy Mahafaly Ralaizanaka ◽  
Mialitiana Rakotomaharo ◽  
...  
Keyword(s):  
Corticosteroid Therapy ◽  
Case Reports ◽  
Inappropriate Prescription ◽  
Disseminated Tuberculosis

scholarly journals Inappropriate prescription of corticosteroid therapy during inflammatory ileo-colitis revealing disseminated tuberculosis with digestive involvement: two case reports

2021 ◽  
Author(s):  
Chantelli Razafindrazoto ◽  
Nitah Randramifidy ◽  
Jolivet Rakotomalala ◽  
Behoavy Ralaizanaka ◽  
Mialitiana Rakotomaharo ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Corticosteroid Therapy ◽  
Case Reports ◽  
Intestinal Tuberculosis ◽  
Inappropriate Prescription ◽  
Disseminated Tuberculosis ◽  
Therapeutic Implications

The similarity between intestinal tuberculosis and Crohn’s disease could lead us to erroneously prescribe corticosteroid therapy. Therefore, it is essential to differentiate the two pathologies because of the therapeutic implications of Crohn’s disease, which can lead to an explosion of tuberculosis symptoms.

Corticosteroids in Tuberculosis

1996 ◽  
Vol 30 (11) ◽  
pp. 1298-1303 ◽  
Author(s):  
Jennifer R Cisneros ◽  
Kim M Murray
Keyword(s):  
Literature Review ◽  
Corticosteroid Therapy ◽  
Case Reports ◽  
Data Extraction ◽  
Individual Case ◽  
Extensive Literature ◽  
Concomitant Disease ◽  
Rapid Reduction ◽  
Medline Search ◽  
Additional Information

OBJECTIVE: TO examine the effects of corticosteroids used for concomitant disease states in patients with latent or active tuberculosis (TB). The role of corticosteroids in the treatment of extrapulmonary TB is also discussed. DATA SOURCES: A MEDLINE search was conducted for the years 1953-1995. The International Pharmaceutical Abstracts service was also used to conduct an extensive literature review. In addition, relevant articles were cross-referenced to screen for additional information. STUDY SELECTION/DATA EXTRACTION: During the literature review, emphasis was placed on human studies and individual case reports. DATA SYNTHESIS: The resurgence of TB in this decade has affected many populations, especially immunocompromised patients. These patients may need corticosteroid therapy for various concomitant diseases that might predispose a patient to develop primary TB infection or reactivate latent TB infection. In appropriate patients, prophylaxis with isoniazid is recommended. Corticosteroid therapy may benefit patients with some forms of extrapulmonary TB. After steroid therapy, improved survival and more rapid reduction of tuberculous symptoms have been noted in cases of tuberculous pleurisy, endobronchial TB, tuberculous meningitis, and tuberculous pericarditis. Corticosteroids may also be useful in controlling both fever and hypersensitivity reactions in pulmonary and extrapulmonary TB, although not routinely used for this purpose. CONCLUSIONS: Corticosteroids may play an important role in TB infection by promoting reactivation of latent infection. Corticosteroids may modify symptoms of some forms of extrapulmonary TB, although randomized, placebo-controlled studies are needed before corticosteroids will have a definitive place in the standard therapy of TB.

A Systematic Review of Subacute Thyroiditis Related to COVID-19

2021 ◽  
Vol 02 ◽  
Author(s):  
Mohammad Al Shatnawi ◽  
Mohammad Sunoqrot ◽  
Basil Al Bakri ◽  
Mohammad Al Oqaily ◽  
Saif Aldeen Al Ryalat
Keyword(s):  
Systematic Review ◽  
Corticosteroid Therapy ◽  
Case Reports ◽  
Individual Case ◽  
Subacute Thyroiditis ◽  
Mesh Network ◽  
The Novel ◽  
Female Predominance ◽  
The Family ◽  
Endocrine Complications

Background: The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which belongs to the family Coronaviridae, is the cause of COVID-19 infection. Its outbreak was declared a pandemic on March 11, 2020. COVID-19 does not involve the respiratory system solely, but other systems were also noted to be affected, including the endocrine, cardiovascular, and gastrointestinal systems. Several case reports and series have been published regarding SAT related to COVID-19 infection, yet management and clinical outcomes of the disease have not been discussed in detail. Methods: This is a systematic review of cases that have been reported to have subacute thyroiditis induced by COVID-19 infection. A systematic search was conducted throughout multiple databases, including PubMed, Google Scholar, and MeSH network. Results: The total number of reported subacute thyroiditis cases attributed to COVID-19 is 24. There was a female predominance (18 females and 6 males) with a female to male ratio of 3:1. Ages ranged from 18 to 69 years (mean = 38.67). Twenty-four symptoms related to thyroiditis were reported, the most common of which being neck pain (95.83%, n=23), palpitations (79.17%, n=19), and fever (66.67%, n=16). The outcome was complete resolution in 70% of cases. Conclusion: The endocrine complications of COVID-19 and their management have been disregarded by most as they are rare. Our knowledge of COVID-19 and its complications is growing rapidly. More favourable outcomes were linked with the use of corticosteroid therapy. Until larger studies can be conducted, the management of SAT caused by COVID-19 remains to be based on each individual case. However, the treatment regimen should include corticosteroid therapy.

scholarly journals MO713ENCAPSULATING PERITONEAL SCLEROSIS IN KIDNEY TRANSPLANT RECIPIENTS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Imen Ouertani ◽  
Azzabi Awatef ◽  
Sahtout Wissal ◽  
Ben Aicha Narjes ◽  
Mrabet Sanda ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Intestinal Obstruction ◽  
Kidney Transplant ◽  
Corticosteroid Therapy ◽  
Clinical Symptoms ◽  
Case Reports ◽  
Calcineurin Inhibitors ◽  
Mtor Inhibitors ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Abstract Background and Aims Encapsulating peritoneal sclerosis (EPS) is a life-threatening complication of long-term peritoneal dialysis (PD). Causative factors are the chronic exposure to bioincompatible PD and peritonitis episodes. Pro-inflammatory state and oxidative stress associated with chronic uremia may further accelerate these pathomechanisms. Clinical symptoms are, essentially, signs of intestinal obstruction. Treatments commonly used are corticosteroids, tamoxifen, immunosuppressants like azathioprine, mycophenolate mofetil (MMF), or mTOR inhibitors which has fibrinolytic properties and may help with reducing inflammation. In the last ten years, the incidence of SEP in kidney transplant recipients has increased, but few cases have been reported. Given the rare nature of this pathology, we decided to publish the cases of two EPS happening after kidney transplantation (KT). Case report We report the cases of two male patients aged 46 and 25 with a history of chronic renal failure, who benefited of continuous ambulatory peritoneal dialysis (CAPD) for three years. The first patient was switched to haemodialysis (HD) for sub-dialysis, with one episode of peritonitis and one episode of catheter infection. The second patient had three episodes of peritonitis complicated by asymptomatic EPS, hence its transfer to HD. Our two patients presented, at 30 and 40 days post KT, an episode of acute intestinal obstruction with abdominal scans fitting with a mechanical bowel obstruction on an encapsulating peritonitis without signs of complication. Both patients were on corticosteroid therapy (15 and 17.5 mg/day) combined with MMF and Calcineurin inhibitors (CNIs) (Tacrolimus). Medical measures were not effecient. Surgical treatment was then considered. During the operation, a classical picture of EPS was found characterized by a thin cocoon-like sclerotic membrane encasing the small bowel. A complete resection of the encapsulating sclerotic membrane and total adhesiolysis were performed, with an immediate improvement on the clinical level. No recurrence was noted for both patients at 5 and 24 months respectively. Conclusion The specificities of our patients compared to the reported cases were the short duration of the PD and the relatively young age. In fact, some studies demonstrated an increased incidence of EPS in younger patients. In addition, this complication has declared itself despite corticosteroid therapy. Some case reports have demonstrated an increase in the incidence of SEP in kidney transplant patients, suggesting the possible implication of CNIs which have a profibrotic effect and may promote peritoneal matrix accumulation.

scholarly journals Usefulness of corticosteroid therapy during chronic disseminated candidiasis: case reports and literature review

2012 ◽  
Vol 67 (6) ◽  
pp. 1493-1495 ◽  
Author(s):  
H. Chaussade ◽  
F. Bastides ◽  
S. Lissandre ◽  
P. Blouin ◽  
E. Bailly ◽  
...  
Keyword(s):  
Literature Review ◽  
Corticosteroid Therapy ◽  
Case Reports ◽  
Disseminated Candidiasis ◽  
Chronic Disseminated Candidiasis

scholarly journals Response to Modified Antitubercular Drug Regime and Antiretroviral Therapy in a Case of HIV Infection with Disseminated Tuberculosis with Isoniazid Induced Toxic Epidermal Necrolysis

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Abhijit Swami ◽  
Bhaskar Gupta ◽  
Prithwiraj Bhattacharjee
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Toxic Epidermal Necrolysis ◽  
Case Reports ◽  
First Line ◽  
Drug Induced ◽  
Antitubercular Drugs ◽  
Disseminated Tuberculosis ◽  
Mucous Membranes ◽  
Life Threatening

Toxic epidermal necrolysis (TEN) is a potentially life-threatening disorder characterized by widespread erythema, necrosis, and bullous detachment of the epidermis and mucous membranes. Without proper management,TEN can cause sepsis leading to death of the patient. Though TEN is commonly drug induced, Isoniazid (INH) has been uncommonly associated with TEN. As INH is one of the first line drugs in treatment of tuberculosis, TEN induced INH needs modification of antitubercular therapy (ATT) with withdrawal of INH from the treatment regime along with other supportive treatments. Patients with HIV infection and disseminated tuberculosis need to be urgently initiated on an effective ATT on diagnosis of tuberculosis. However, if the patient develops potential life-threatening toxicity to first line antitubercular drugs like INH, an alternative effective ATT combination needs to be started as soon as the condition of the patient stabilizes as most of these patients present in advanced stage of HIV infection and this is to be followed by antiretroviral therapy (ART) as per guidelines. The present case reports the effectiveness of an ATT regime comprising Rifampicin, Pyrazinamide, Ethambutol, and Levofloxacin along with ART in situations where INH cannot be given in disseminated tuberculosis in HIV patients.

Corticosteroid therapy for refractory infections in chronic granulomatous disease: case reports and review of the literature

2006 ◽  
Vol 97 (2) ◽  
pp. 257-261 ◽  
Author(s):  
Marco A. Yamazaki-Nakashimada ◽  
E Richard Stiehm ◽  
Dino Pietropaolo-Cienfuegos ◽  
Victor Hernandez-Bautista ◽  
Francisco Espinosa-Rosales
Keyword(s):  
Chronic Granulomatous Disease ◽  
Corticosteroid Therapy ◽  
Case Reports ◽  
Granulomatous Disease ◽  
Review Of The Literature ◽  
Disease Case

scholarly journals Myasthenia gravis and COVID-19: a systematic review of case reports and case series

2021 ◽  
Vol 50 (2) ◽  
pp. 87-106
Author(s):  
Débora Lilian Roveron ◽  
Ivan Luiz Gonçalves dos Santos ◽  
Julio Luiz Gonçalves dos Santos ◽  
Najila Fernandes Alem ◽  
João Gabriel Pacetti Capobianco
Keyword(s):  
Systematic Review ◽  
Respiratory Failure ◽  
Myasthenia Gravis ◽  
Corticosteroid Therapy ◽  
Neuromuscular Transmission ◽  
Case Reports ◽  
Ventilatory Support ◽  
Case Series ◽  
Length Of Hospital Stay ◽  
Main Factor

Myasthenia gravis (MG) is an autoimmune disease involving neuromuscular transmission and possible respiratory failure when concomitant with COVID-19. The aim of this study was to analyze the need for ventilatory support (VS), length of hospital stay (LOS) and mortality in patients diagnosed with MG and COVID-19. In this systematic review, PubMed, SciELO, LILACS, MEDLINE and IBECS databases were searched for primary studies published from January 2010 to March 2021, with no language restrictions. Fourteen eligible studies were identified. The main factor associated with the need for VS was the use of antibiotics other than azithromycin (AZM) for the treatment of COVID-19 (RR 1.60; 95% CI 1.20–2.91; p = 0.009). Patients who used hydroxychloroquine (HCQ)  and AZM had almost twice the risk of needing invasive ventilatory support (IVS) (RR 1.94; 95% CI 1.07-3.52; p = 0.16). There were nonsignificant trends towards less need for IVS in patients who used intravenous immunoglobulin (IVIg) and corticosteroid therapy (RR 0.54; 95% CI 0.09–3.26; p = 0.60). There was a trend towards shorter LOS in patients who received therapy with IVIg and corticosteroid therapy [8 (5 - 8) vs 19 (12.2–23.7); p = 0.007]. 10.3% (n = 4/39) died and 100% did not use IVIg or IVIg and prednisone. There was a non-significant trend towards higher mortality in patients who used AZM (RR 2.55; 95% CI 0.26–30.02; p = 0.60).  IVIg and corticotherapy presented themselves as a favorable alternative in relation to the outcomes.KEY WORDS: Coronavirus infections; length of stay; Myasthenia gravis; Respiratory insufficiency.

Sclerosing pancreato-cholangitis responsive to corticosteroid therapy: Report of 2 case reports and review

2001 ◽  
Vol 53 (4) ◽  
pp. 518-522 ◽  
Author(s):  
Akira Horiuchi ◽  
Shigeyuki Kawa ◽  
Hideaki Hamano ◽  
Yasuhide Ochi ◽  
Kendo Kiyosawa
Keyword(s):  
Corticosteroid Therapy ◽  
Case Reports

scholarly journals Adult presentation of multisystem inflammatory syndrome (MIS) associated with recent COVID-19 infection: lessons learnt in timely diagnosis and management

2021 ◽  
Vol 14 (10) ◽  
pp. e243114
Author(s):  
Qiang Yao ◽  
Laura Waley ◽  
Natasha Liou
Keyword(s):  
Ethnic Minority ◽  
Corticosteroid Therapy ◽  
Inflammatory Markers ◽  
Similar Case ◽  
Case Reports ◽  
Adult Woman ◽  
Diagnosis And Management ◽  
Inflammatory Syndrome ◽  
Symptoms And Signs ◽  
Adult Presentation

Multisystem inflammatory syndrome in adults (MIS-A) is an uncommon and under-recognised postinfectious manifestation that presents 4–6 weeks after COVID-19 infection. Patients affected tend to be young or middle-aged, from ethnic minority backgrounds and previously healthy. In addition to high fever and myalgia, there are a myriad of extrapulmonary symptoms and signs, including cardiac, gastrointestinal, neurological and dermatological involvement. Cardiovascular shock and markedly raised inflammatory markers are prominent features, while significant hypoxia is uncommon. Patients respond well to corticosteroid therapy, but failure of clinicians to recognise this recently identified phenomenon, which can mimic common conditions including sepsis, could delay diagnosis and treatment. Here we present a case of MIS-A in an adult woman, compare her presentation and management with other similar case reports, and reflect on how clinicians can learn from our experiences.

Sign in / Sign up

Export Citation Format

Share Document