scholarly journals Usefulness of corticosteroid therapy during chronic disseminated candidiasis: case reports and literature review

2012 ◽  
Vol 67 (6) ◽  
pp. 1493-1495 ◽  
Author(s):  
H. Chaussade ◽  
F. Bastides ◽  
S. Lissandre ◽  
P. Blouin ◽  
E. Bailly ◽  
...  
Keyword(s):  
Literature Review ◽  
Corticosteroid Therapy ◽  
Case Reports ◽  
Disseminated Candidiasis ◽  
Chronic Disseminated Candidiasis

Corticosteroids in Tuberculosis

1996 ◽  
Vol 30 (11) ◽  
pp. 1298-1303 ◽  
Author(s):  
Jennifer R Cisneros ◽  
Kim M Murray
Keyword(s):  
Literature Review ◽  
Corticosteroid Therapy ◽  
Case Reports ◽  
Data Extraction ◽  
Individual Case ◽  
Extensive Literature ◽  
Concomitant Disease ◽  
Rapid Reduction ◽  
Medline Search ◽  
Additional Information

OBJECTIVE: TO examine the effects of corticosteroids used for concomitant disease states in patients with latent or active tuberculosis (TB). The role of corticosteroids in the treatment of extrapulmonary TB is also discussed. DATA SOURCES: A MEDLINE search was conducted for the years 1953-1995. The International Pharmaceutical Abstracts service was also used to conduct an extensive literature review. In addition, relevant articles were cross-referenced to screen for additional information. STUDY SELECTION/DATA EXTRACTION: During the literature review, emphasis was placed on human studies and individual case reports. DATA SYNTHESIS: The resurgence of TB in this decade has affected many populations, especially immunocompromised patients. These patients may need corticosteroid therapy for various concomitant diseases that might predispose a patient to develop primary TB infection or reactivate latent TB infection. In appropriate patients, prophylaxis with isoniazid is recommended. Corticosteroid therapy may benefit patients with some forms of extrapulmonary TB. After steroid therapy, improved survival and more rapid reduction of tuberculous symptoms have been noted in cases of tuberculous pleurisy, endobronchial TB, tuberculous meningitis, and tuberculous pericarditis. Corticosteroids may also be useful in controlling both fever and hypersensitivity reactions in pulmonary and extrapulmonary TB, although not routinely used for this purpose. CONCLUSIONS: Corticosteroids may play an important role in TB infection by promoting reactivation of latent infection. Corticosteroids may modify symptoms of some forms of extrapulmonary TB, although randomized, placebo-controlled studies are needed before corticosteroids will have a definitive place in the standard therapy of TB.

Adjuvant Corticosteroid Therapy for Chronic Disseminated Candidiasis in Patients with Acute Leukemia

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 4723-4723
Author(s):  
Shenxian Qian ◽  
Kuang Chen
Keyword(s):  
Abdominal Pain ◽  
Acute Leukemia ◽  
Corticosteroid Therapy ◽  
Antifungal Therapy ◽  
Clinical Symptoms ◽  
Conflicts Of Interest ◽  
European Organization ◽  
Disseminated Candidiasis ◽  
Protein Levels ◽  
Chronic Disseminated Candidiasis

Abstract Abstract 4723 Chronic disseminated candidiasis (CDC) is typically observed during neutrophil recovery in patients with acute leukemia and requires protracted antifungal therapy. Our objective was to document the efficacy and tolerance of corticosteroid therapy (CST) in patients with symptomatic CDC, including those who experienced fever and abdominal pain despite ongoing antifungal therapy. We performed a study involving 6 adult patients who experienced ongoing symptomatic CDC despite receipt of appropriate antifungal therapy for whom adjuvant oral CST therapy was initiated. All cases of CDC were proven or probable, as determined on the basis of the European Organization for Research and Treatment of Cancer-Mycosis Study Group definition criteria, and occurred in patients with leukemia.The common manifestations in these six patients were persistent fever, splenohepatomegalia and percussion pain in hepatic region. Meanwhile, 2 of them were accompanied with appearance of painful and diffuse cataneous nodules, expectoration and dyspnoea. The abnormal laboratory test observed of them was increase of alkaline phosphatase. Computed tomography scan showed multiple hypodense lesions in the liver and spleen in all the five patients; one of them showed multiple nodular patchy shadows in bone. Nuclear magnetic resonance imaging showed multiple abnormal signal in liver, spleen and kidneys in one of the patients. Three patients had positive blood candida tropicalis cultures. liver biopsy in one patient was negative for fungal. Two patients received Fluconazole therapy empirically, but it was replaced by Itraconazole later in one because of unresponsiveness to the drug. Three patients received Itraconazole therapy and in one received voriconazole therapy empirically. CDC-attributable clinical symptoms resolved with CST, which was started an average of 31 day since antifungal therapy was initiated. Fever and abdominal pain disappeared a median of 5–6 days, and serum fibrinogen and C-reactive protein levels returned to normal values within 14–30 days. Hepatosplenic microabscesses decreased or disappeared within a mean period of 45 days (range, 27–167 days). All the six patients received further chemotherapy smoothly after the treatment antifungal therapy combined with CST,No relapses of CDC were observed during a median duration of follow-up of 3.2 years (range, 2.6–3.8 years).CONCLUSION: In adults who experience persistently symptomatic CDC despite ongoing receipt of antifungal therapy, CST involving a prednisone equivalent at a dosage of > or =0.25 mg/kg per day for at least 3 weeks is associated with a prompt resolution of symptoms and of inflammatory response. These findings support the pathophysiological hypothesis that CDC belongs to the spectrum of fungus-related immune reconstitution inflammatory syndrome. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Clinical characteristics and outcomes of patients with chronic disseminated candidiasis who need adjuvant corticosteroid therapy

2017 ◽  
Vol 56 (6) ◽  
pp. 782-786 ◽  
Author(s):  
Young-Rock Jang ◽  
Min-Chul Kim ◽  
Taeeun Kim ◽  
Yong Pil Chong ◽  
Sang-Oh Lee ◽  
...  
Keyword(s):  
Corticosteroid Therapy ◽  
Clinical Characteristics ◽  
Disseminated Candidiasis ◽  
Chronic Disseminated Candidiasis

scholarly journals Adjuvant Corticosteroid Therapy for Chronic Disseminated Candidiasis

2008 ◽  
Vol 46 (5) ◽  
pp. 696-702 ◽  
Author(s):  
F. Legrand ◽  
M. Lecuit ◽  
B. Dupont ◽  
E. Bellaton ◽  
M. Huerre ◽  
...  
Keyword(s):  
Corticosteroid Therapy ◽  
Disseminated Candidiasis ◽  
Chronic Disseminated Candidiasis

Response of Symptomatic Persistent Chronic Disseminated Candidiasis to Corticosteroid Therapy in Immunosuppressed Pediatric Patients

2018 ◽  
Vol 37 (7) ◽  
pp. 686-690 ◽  
Author(s):  
Vered Shkalim-Zemer ◽  
Itzhak Levi ◽  
Salvador Fischer ◽  
Hannah Tamary ◽  
Joanne Yakobovich ◽  
...  
Keyword(s):  
Corticosteroid Therapy ◽  
Pediatric Patients ◽  
Disseminated Candidiasis ◽  
Chronic Disseminated Candidiasis

Reticular erythematous mucinosis: Literature review and case report of a 24-year-old patient with systemic erythematosus lupus

Lupus ◽  
2020 ◽  
pp. 096120332096570
Author(s):  
Juliana P Ocanha-Xavier ◽  
Camila O Cola-Senra ◽  
Jose Candido C Xavier-Junior
Keyword(s):  
Systematic Review ◽  
Case Report ◽  
Literature Review ◽  
English Language ◽  
Case Reports ◽  
Histopathological Diagnosis ◽  
Skin Disorders ◽  
Histopathological Findings ◽  
Inflammatory Skin

Reticular erythematous mucinosis (REM) was first described 50 years ago, but only around 100 case reports in English have been published. Its relation with other inflammatory skin disorders is still being debated. We report a case of REM, including the clinical and histopathological findings. Also, a systematic review of 94 English-language reported cases is provided. The described criteria for clinical and histopathological diagnosis are highlighted in order to REM can be confidently diagnosed.

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