scholarly journals A case of vasculitis case with unusual renal pathological findings presenting with rapidly progressing renal failure

2020 ◽  
Vol 8 (12) ◽  
pp. 2852-2856
Author(s):  
Hyo Jung An ◽  
Ha Nee Jang ◽  
Tae Won Lee ◽  
Changhyo Yoon ◽  
Dong Jun Park ◽  
...  
Keyword(s):  
Renal Failure ◽  
Pathological Findings

scholarly journals Lily Poisoning in Domestic Cats

2018 ◽  
Vol 47 ◽  
Author(s):  
Welden Panziera ◽  
Claiton Ismael Schwertz ◽  
Luan Cleber Henker ◽  
Guilherme Konradt ◽  
Daniele Mariath Bassuino ◽  
...  
Keyword(s):  
Renal Failure ◽  
Rural Areas ◽  
Ornamental Plants ◽  
Clinical Signs ◽  
Clinical History ◽  
Final Diagnosis ◽  
Ventral Surface ◽  
Pathological Findings ◽  
Cell Degeneration ◽  
Mixed Breed

Background: Cases of plant intoxication in small animals are observed frequently in the domestic environment, mainly because most dogs and cats live in households and occasionally have access to streets and rural areas. Among such toxic agents, ornamental plants of the genus Lilium and Hemerocallis, which are potentially nephrotoxic to the feline species, are highlighted. Affected cats start presenting clinical signs 1-6 h after plant ingestion. Renal failure takes place in 12-72 h, and death may occur in an interval ranging from three to seven days. The objective of this article is to describe the epidemiological, clinical and pathological findings of lily (Lilium sp.) poisoning in two cats.Case: The aspects of lily poisoning in two cats are described (cat #1 and cat #2). Cat #1 was a 3-year-old, mixed breed female cat, which presented a clinical history of anorexia, apathy, drooling, vomiting and polydipsia. Serum biochemical analysis revealed creatinine elevation (21.2 mg/dL), as well as hyperphosphatemia (19 mg/dL). Seventy-two h after the onset of clinical signs, renal failure progressed to anuria, followed by death. The second animal of this report (cat #2) was a 2-year-old, mixed-breed male cat. The animal was found dead by the owner without displaying any previous clinical signs.  Cats #1 and #2 ingested leaves of lily, which were present in their households as ornamental plants. At necropsy, the kidneys of both cats presented mild enlargement. Moderate perirenal edema was also noted. Cat #1 showed morphologic extrarenal uremic lesions, characterized by ulcers in the oral mucosa and in the margin of the tongue ventral surface. Microscopic lesions observed in both cases were similar and compatible with acute toxic nephropathy. Histologically, severe epithelial cell degeneration and necrosis of proximal and distal convoluted tubules were noted. Other renal microscopic findings included hyaline and granular casts, tubule regeneration and occasional birefringent oxalate crystals. Cat #1 also presented moderate white matter vacuolation in the telencephalon and cerebellum.Discussion: The epidemiologic, clinical and pathological findings reported in the present study are similar to previous descriptions of lily poisoning in cats. Lily poisoning has been described in both males and females, without breed and age predisposition, similarly to what has been found in the present study. Kidney metabolite excretion, including the elimination of molecules such as creatinine, urea, and phosphorus is usually compromised in these cases, which was noted in cat #1. The same animal showed extrarenal manifestations of renal failure, leading to a clinical presentation of uremic syndrome, which is not frequent in these intoxications. Animals intoxicated by lily usually die from renal failure and anuria. In most cases, lesions are restricted to the kidneys. In the reported cases, the microscopical lesions consisted of tubule epithelial cells degenerative changes and necrosis. Acute lily intoxication in cats must be differentiated from other conditions, such as intoxications due to aminoglycoside antibiotics, heavy metals, nonsteroidal anti-inflammatory drugs, antifungal agents, chemotherapeutic drugs, and ethylene glycol. The knowledge regarding the toxic potential of ornamental plants is fundamental in order to prevent such events of intoxication, as well as to reach the final diagnosis. Epidemiological, clinical and pathological findings were essential to conclude the final diagnosis.

Renal Pathological Findings in Action Myoclonus-Renal Failure Syndrome

Nephron ◽  
2019 ◽  
Vol 144 (2) ◽  
pp. 55-58 ◽  
Author(s):  
Geoffroy Desbuissons ◽  
Isabelle Brocheriou ◽  
Guy Touchard ◽  
Jean-Michel Goujon ◽  
Aurélie Méneret ◽  
...  
Keyword(s):  
Renal Failure ◽  
Pathological Findings ◽  
Action Myoclonus

scholarly journals A case of ramucirumab-induced renal failure with nephrotic-range proteinuria and its pathological findings

2021 ◽  
Vol 14 (3) ◽  
pp. e239603
Author(s):  
Yuta Nakano ◽  
Jiro Kumagai ◽  
Kiyotaka Nagahama ◽  
Hajime Fujisawa
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Endothelial Cell ◽  
Epithelial Cell ◽  
Serum Creatinine ◽  
Kidney Injury ◽  
Pathological Findings ◽  
Cell Hyperplasia ◽  
Nephrotic Range Proteinuria ◽  
Cecal Cancer

Ramucirumab-induced renal dysfunction is rarely reported. The pathology of ramucirumab-associated nephropathy in past reports primarily shows thrombotic microangiopathy (TMA) lesions but podocytopathy is not yet known. We report a case of kidney injury induced by ramucirumab in a 71-year-old man with cecal cancer. He was referred to our department for increasing serum creatinine (Cr) levels from 1.08 mg/dL to 2.56 mg/dL after changing anticancer drugs from bevacizumab to ramucirumab. He showed nephrotic-range proteinuria (12.1 g/gCr). A renal biopsy revealed endothelial cell injuries, such as TMA and podocytopathy with epithelial cell hyperplasia, which looked like a crescent. After discontinuing ramucirumab, his renal function and proteinuria improved, as seen by his Cr levels and proteinuria which decreased to 1.74 mg/dL and 1.21 g/gCr, respectively, in 3 months. Unlike previous reports, we found that ramucirumab caused podocyte injuries.

scholarly journals Downer cow syndrome causing rhabdomyolysis and acute renal failure in a 17-month-old Guzerá heifer

2022 ◽  
Vol 52 (2) ◽  
Author(s):  
Teresa Souza Alves ◽  
Mariana da Costa Gonzaga ◽  
Igor Louzada Moreira ◽  
Mizael Machado ◽  
Davi Emanuel Ribeiro de Sousa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Clinical Laboratory ◽  
Cranial Nerves ◽  
Occult Blood ◽  
Gravid Uterus ◽  
Pathological Findings ◽  
Road Transportation ◽  
Downer Cow Syndrome

ABSTRACT: The downer cow syndrome (DCS) is characterized by an alert cow showing inability or reluctance to stand for 12 hours or more. This paper reported clinical, laboratory, and pathological findings in a Guzerá heifer with rhabdomyolysis, pigmenturia and acute renal failure following DCS. A 17-month-old Guzerá heifer was transported via a 350-km ride in a truck and showed sternal recumbency and severe difficulty in standing and walking. Neurological examination was unremarkable, and the heifer presented normal response to cranial nerves and spinal cord tests. Rectal palpation revealed a 5-month gravid uterus. No other abnormalities were noted in the pelvis or around the coxofemoral joints. Biochemical abnormalities included extremely high muscular enzyme activities (creatine phosphokinase and aspartate aminotransferase) and high creatinine levels. Urinalysis revealed blackish and cloudy urine, proteinuria, and a positive occult blood test. Spinal cord ultrasonography showed no abnormalities. This report highlighted an uncommon clinical presentation (myoglobinuria) and pathological findings in a heifer with DCS as a consequence of severe compressive muscle damage. Practitioners and producers must be aware of the risk of careless road transportation for long distances of cattle, especially obese cows, avoiding unnecessary suffering and expenses due to DCS.

The Spectrum Of Pathological Findings Of Kidney Injury In The Cases Of Multiple Myeloma: A Clinico-Pathological Study Of 93 Consecutive Autopsy Cases

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 5321-5321
Author(s):  
Sohtaro Mine ◽  
Shotaro Hagiwara ◽  
Risen Hirai ◽  
Akira Tanimura ◽  
Miki Nakamura ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Renal Failure ◽  
Kidney Injury ◽  
Myeloma Cell ◽  
Pathological Findings ◽  
Myeloma Cells ◽  
Cast Nephropathy ◽  
Direct Invasion ◽  
Duration Of Illness

Abstract Background Kidney injury and/or renal failure are common complication in multiple myeloma. Well known mechanism is deposition of free immunoglobulin light chains in renal tubules leading to cast nephropathy and renal failure. In addition, not only cast nephropathy, but also invasion of myeloma cells is frequently found in autopsied cases of multiple myeloma. Recent development of treatment improved the remission rate and survival of multiple myeloma. Few data exist about pathological findings of kidney injury and it is not well known about kidney findings in autopsy cases at era of novel agent. We investigated the pathological findings and the factors associated with kidney injury in the consecutively autopsy cases. Methods We reviewed the autopsy reports and medical records of 93 consecutively autopsied multiple myeloma cases between 1979 and 2012 at the National Medical Center for Global Health and Medicine in Tokyo, Japan. Patient profile, the clinical records including treatment and the duration of illness, the type of monoclonal gammopathy, clinical stage and history of treatment were studied. Durie & Salmon's criteria was used for diagnosis and staging. The pathological findings like cast nephropathy, invasion of myeloma cell at kidney and the other findings of whole samples were studied gross and microscopically. Immunohistochemistry and Congo-red stain were performed. The pathological findings and the factors were statistically analyzed using Student's t-test and the chi-square test. Results In 93 autopsy cases, 58% was male. Mean age and the duration of illness were 64.3(38-85) years old and 41 months (24.4-37.5). Thirteen patients and 14 were treated with SCT and hemodialysis (Table. 1). Cast nephropathy and direct invasion about kidney were observed in 51.2% and 29.3%, respectively. Other frequent finding associated with myeloma was renal amyloidosis (29%). Frequent non-specific findings were arteriosclerosis (76 %), glomerulosclerosis (61%). Combination of findings were found in 66% cases (Fig.1). The tumor volume in bone marrow (percentage of myeloma cells in cellular component) had correlation to incidence of direct invasion (Pearson's correlation factor is 0.55, p<0.005). Conclusion Autopsy findings of the kidney are various, complicated pathological findings of two or more was not uncommon. Frequency of cast nephropathy was high, but the direct invasion of the tumor cells was observed in about one-third of the cases. Correlation was observed between the kidney and invasive tumor burden in the bone marrow. Therefore, in the advanced stage myeloma, when tumor cell occupy more than about 60% of the bone marrow should be considered renal failure mechanism by myeloma cell infiltration. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Angiotensin Type-1 Receptor Blockade May Not Protect Kidney against Cisplatin-Induced Nephrotoxicity in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Roya Rastghalam ◽  
Mehdi Nematbakhsh ◽  
Mehrnoosh Bahadorani ◽  
Fatemeh Eshraghi-Jazi ◽  
Ardeshir Talebi ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Serum Levels ◽  
Receptor Blockade ◽  
Pathological Findings ◽  
Blood Samples ◽  
Group 3 ◽  
Nephroprotective Effect ◽  
Angiotensin Type

Background. Cisplatin (CDDP) is an anticancer drug, which is accompanied with major side effects including nephrotoxicity. We tested two doses of losartan (10 and 20 mg/kg/day) against nephrotoxicity in a rat model treated with daily administration of CDDP (2.5 mg/kg/day). Methods. Five groups of rats were examined. Groups 1 and 2 received losartan 10 and 20 mg/kg/day, i.p, for a period of 10 days. Group 3 received saline for 10 days, but from day 3 the animals received CDDP (2.5 mg/kg/day, i.p) for the next seven days. Groups 4 and 5 received treatment regimen the same as groups 1 and 2, but from day 3 they also received CDDP for the next seven days. At the end of the experiment, blood samples were obtained and the kidneys were removed to undergo pathological investigation and to obtain supernatant from homogenized tissue. Results. CDDP induced nephrotoxicity, but the serum levels of creatinine and blood urea nitrogen were not attenuated by losartan. The pathological findings confirmed that losartan did not have nephroprotective effect in this experimental model. Conclusion. According to the findings, losartan could not improve renal function impaired by toxicity induced by continuous doses of CDDP, and also it worsened the renal failure.

DYSPEPSIA SYNDROME AND HELICOBACTER PYLORI INFECTION IN END STAGE RENAL FAILURE

2000 ◽  
Vol 15 (12) ◽  
pp. H2-H2
Author(s):  
IS Mertasudira ◽  
JR Saketi ◽  
A. Djumhana ◽  
J. Widjojo ◽  
SA Abdurachman
Keyword(s):  
Renal Failure ◽  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection ◽  
End Stage Renal Failure ◽  
End Stage

ESTIMATING EFFECTS OF SYSTEMATIC TREATMENT ON RENAL FAILURE AND DEATH WITHOUT A PARALLEL PLACEBO CONTROL GROUP

Nephrology ◽  
2000 ◽  
Vol 5 (3) ◽  
pp. A97-A97
Author(s):  
Hoy We ◽  
Baker P ◽  
Wang Z ◽  
Cass A ◽  
Mathews Jd ◽  
...  
Keyword(s):  
Renal Failure ◽  
Control Group ◽  
Placebo Control ◽  
Systematic Treatment ◽  
Placebo Control Group
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