scholarly journals Should clinical suspicion shift to ampicillin resistance organisms in certain preterm premature rupture of membranes scenarios?: Case of early‐onset sepsis caused by E coli

2019 ◽  
Vol 7 (12) ◽  
pp. 2306-2310 ◽  
Author(s):  
Anirudh Bandu ◽  
Anthony Barone ◽  
Santosh Parab ◽  
Nisha Lakhi
Keyword(s):  
Early Onset ◽  
Clinical Suspicion ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Ampicillin Resistance ◽  
E Coli ◽  
Preterm Premature Rupture ◽  
Early Onset Sepsis

scholarly journals Low Vitamin D Levels Increase the Risk of Early Onset Neonatal Sepsis

2020 ◽  
pp. 87-91
Author(s):  
Lisnawati Yuyun ◽  
Ali Sungkar ◽  
Rinawati Rohsiswatno ◽  
Noroyono Wibowo ◽  
Denni Hermartin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Umbilical Cord ◽  
Neonatal Sepsis ◽  
Medical Records ◽  
Early Onset ◽  
Study Data ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Vitamin D Levels

Abstract Objective: To identify the association between maternal and umbilical cord vitamin D levels with suspects of early-onset of neonatal sepsis (EONS) in newborns from mothers with preterm premature rupture of membranes (PPROM).Methods: This is a retrospective cohort study conducted from January 2017 to Augusts 2018. Data was taken consecutively from medical records and previous study data at Dr. Cipto Mangunkusumo and Persahabatan Hospital, Jakarta.Results: From total of 72 infants from mothers with PPROM, 22 infants (31%) were EONS-suspected and 50 infants (69%) were not EONS-suspected. There was a significant association between maternal and umbilical cord vitamin D levels with EONS.Conclusion: There was a significant association between maternal and umbilical cord vitamin D levels with EONS.Keywords: early-onset neonatal sepsis, preterm premature rupture of membrane, vitamin D,   Abstrak Tujuan: Untuk mengetahui hubungan antara kadar vitamin D maternal dan tali pusat dengan risiko tejadinya Sepsis Neonatal Awitan Dini (SNAD) pada bayi dari ibu dengan Ketuban Pecah Dini (KPD).Metode: Desain penelitian kohort retrospektif secara consecutive sampling. Data diambil dari rekam medis dan data penelitian sebelumnya di Rumah Sakit Umum Pusat Nasional (RSUPN) Dr. Cipto Mangunkusumo dan Rumah Sakit Umum Pusat (RSUP) Persahabatan, Jakarta. Hasil:  Dari 72 bayi yang dilahirkan dari ibu dengan KPD, 22 bayi (31%) diantaranya diduga mengalami SNAD, sedangkan 50 bayi lainnya tidak mengalami SNAD. Terdapat hubungan yang bermakna antara kadar vitamin D maternal dan tali pusat dengan kejadian SNAD. Kesimpulan:Terdapathubungan yang bermakna antara kadar vitamin D maternal dan tali pusat dengan kejadian SNAD.Kata kunci: ketuban pecah dini,  sepsis neonatal awitan dini, vitamin D

Placenta inflammation, vaginal microbiome and Early-Onset Neonatal Sepsis (EONS) after Preterm Premature Rupture of Membranes (PPROM)

Placenta ◽  
2021 ◽  
Vol 112 ◽  
pp. e66
Author(s):  
Hiller G.G. Ruth ◽  
Zöllkau Janine ◽  
Pastuschek Jana ◽  
Heimann Yvonne ◽  
G.A. Borges Luiz ◽  
...  
Keyword(s):  
Neonatal Sepsis ◽  
Early Onset ◽  
Vaginal Microbiome ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture

scholarly journals Outcome of neonates born to mothers with premature rupture of membranes

2021 ◽  
Vol 11 (2) ◽  
pp. 197-203
Author(s):  
Mangal Charan Murmu ◽  
Ratikanta Mahala ◽  
Jyoti Ranjan Champatiray ◽  
Madhusmita Pradhan
Keyword(s):  
Intrauterine Infection ◽  
Neonatal Infection ◽  
Preterm Neonates ◽  
Perinatal Morbidity ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
E Coli ◽  
Medical College ◽  
Early Onset Sepsis ◽  
A Prospective Study

Premature rupture of membranes (PROM) is a syndrome characterized by rupture of the fetal membranes before labour. Acute chorioamnionitis complicates 0.5% - 10% of all pregnancies but the incidence may be as high as 3-25% in pregnancies complicated by PROM of more than 24 hours duration. Intrauterine infection specially chorioamnionitis is one of the most serious problems found by the practicing Obstetrician and subsequently by the Pediatrician. The incidence of neonatal infection for infants born to women with PROM range from 1 – 2.6%.   To know the incidence, clinical course, outcome of early onset sepsis following PROM more than 18 hours. Materials & Methods: This is a prospective study conducted from December 2018 to September 2020 in SCB Medical College and Hospital and SVPPGIP Cuttack. All neonates born to healthy mothers with PROM more than 18 hours during their hospital stay were studied. 53.3% of the cases had Premature rupture of membranes of 18-24 hours duration,38.3% cases had Premature rupture of membranes of 24 to 72 hour and 8.4 % cases had Premature rupture of membranes of more than 72 hr. RDS was the most common clinical manifestation (37.5%) followed by septicemia (10%), meningitis (1.7%) and pneumonia 1.7%. Most common organisms isolated in blood culture were Staphylococcus followed by Klebsiella, E. coli, Pseudomonas. The incidence of neonatal infection in neonates born to mothers with PROM was 10%. Premature rupture of membranes is responsible for increased perinatal morbidity among preterm neonates & directly proportional to duration of PROM. 

scholarly journals Meconium in the Amniotic Fluid of Pregnancies Complicated by Preterm Premature Rupture of Membranes Is Associated With Early Onset Neonatal Sepsis

1995 ◽  
Vol 3 (1) ◽  
pp. 22-27 ◽  
Author(s):  
Michael J. Kupferminc ◽  
Elizabeth Wickstrom ◽  
Nam H. Cho ◽  
Patricia M. Garcia
Keyword(s):  
Amniotic Fluid ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Multiple Logistic Regression Analysis ◽  
Study Group ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Group B ◽  
Heart Rate Pattern

Objective: This study was to determine the significance of meconium in the amniotic fluid of pregnancies complicated by preterm premature rupture of membranes (PPROM) without labor.Methods: A case-control study of 31 pregnancies complicated by PPROM at 27–36 weeks gestation with meconium present (study group) and 93 pregnancies complicated by PPROM but without meconium was performed. The patients were matched for year of delivery, gestational age, race, and parity. Pregnancy and neonatal outcome variables of the 2 groups were compared.Results: The incidence of early onset neonatal sepsis was significantly increased in the study group (16.1% vs. 1.1%; P < 0.001). Similarly, chorioamnionitis (48.3% vs. 22.5%; P < 0.01), cesarean delivery for a nonreassuring fetal heart rate pattern (19.4% vs. 3.2%; P < 0.01), a 5-min Apgar score < 7 (22.5% vs. 8.6%; P < 0.05), and fetal growth retardation (FGR) (12.9% vs. 2.2%; P < 0.05) were also more common in pregnancies complicated by PPROM with meconium. The mean umbilical cord arterial pH was significantly lower in these pregnancies (7.18 ± 0.07 vs. 7.28 ± 0.08; P < 0.001). After controlling for confounding variables with multiple logistic regression analysis, we found that meconium in the amniotic fluid remained associated with early onset neonatal sepsis.Conclusions: The presence of meconium in the amniotic fluid of pregnancies complicated by PPROM is associated with an increased incidence of early onset neonatal group B β-hemolytic streptococcus (GBBS) sepsis.

scholarly journals Treatment of mid-trimester preterm premature rupture of membranes (PPROM) with multi-resistant bacteria-colonized anhydramnion with continuous amnioinfusion and meropenem: a case report and literature review

2021 ◽  
Author(s):  
Michael Tchirikov ◽  
Ronja Ocker ◽  
Gregor Seliger ◽  
Katarina Chaoui ◽  
Stefan Moritz ◽  
...  
Keyword(s):  
Male Infant ◽  
Resistant Bacteria ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Amniotic Cavity ◽  
E Coli ◽  
Preterm Premature Rupture ◽  
Systemic Antibiotics

Abstract Purpose Treatment of mid-trimester classic preterm premature rupture of membranes (PPROM) with systemic antibiotics has limited success in the prevention of chorioamnionitis, funisitis and fetal inflammatory response syndrome because of very low transplacental passage. Methods Here we report a case of PPROM at 18 weeks gestation with anhydramnion colonized by multi-resistant Escherichia coli (E. coli). A catheter system was implanted at 23/2nd weeks gestation, enabling long-term continuous lavage of the amniotic cavity with Amnion Flush Solution (100 ml/h combined with intraamniotic meropenem application). Results The patient gave birth to a preterm male infant at 28/3rd without any signs of infection. In a follow-up examination at 24 months, there was no neurological disturbance or developmental delay. Conclusion The classic PPROM with multi-resistant E. coli colonization could be treated with continuous amnioinfusion and meropenem.

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