Percutaneous endovascular delivery of calcium chloride to the intact porcine carotid artery: A novel animal model of arterial calcification

2020 ◽  
Vol 96 (4) ◽  
Author(s):  
Sérgio R. Abrão ◽  
Carlos M. Campos ◽  
Rafael Cavalcante ◽  
Jeroen Eggermont ◽  
Pedro Lemos ◽  
...  
Keyword(s):  
Animal Model ◽  
Carotid Artery ◽  
Calcium Chloride ◽  
Arterial Calcification ◽  
Porcine Carotid Artery

scholarly journals Pharmacogenomics of estrogens on changes in carotid artery intima-medial thickness and coronary arterial calcification: Kronos Early Estrogen Prevention Study

2016 ◽  
Vol 48 (1) ◽  
pp. 33-41 ◽  
Author(s):  
Virginia M. Miller ◽  
Gregory D. Jenkins ◽  
Joanna M. Biernacka ◽  
John A. Heit ◽  
Gordon S. Huggins ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Carotid Artery ◽  
Hormone Treatment ◽  
Arterial Calcification ◽  
Nucleotide Polymorphisms ◽  
Prevention Study ◽  
Conjugated Equine Estrogens ◽  
17Β Estradiol ◽  
Innate Immunity Pathway ◽  
Intima Medial Thickness

Prior to the initiation of menopausal hormone treatment (MHT), genetic variations in the innate immunity pathway were found to be associated with carotid artery intima-medial thickness (CIMT) and coronary arterial calcification (CAC) in women ( n = 606) enrolled in the Kronos Early Estrogen Prevention Study (KEEPS). Whether MHT might affect these associations is unknown. The association of treatment outcomes with variation in the same 764 candidate genes was evaluated in the same KEEPS participants 4 yr after randomization to either oral conjugated equine estrogens (0.45 mg/day), transdermal 17β-estradiol (50 μg/day), each with progesterone (200 mg/day) for 12 days each month, or placebo pills and patch. Twenty SNPs within the innate immunity pathway most related with CIMT after 4 yr were not among those associated with CIMT prior to MHT. In 403 women who completed the study in their assigned treatment group, single nucleotide polymorphisms (SNPs) within the innate immunity pathway were found to alter the treatment effect on 4 yr change in CIMT (i.e., significant interaction between treatment and genetic variation in the innate immunity pathway; P < 0.001). No SNPs by treatment effects were observed with changes of CAC >5 Agatston units after 4 yr. Results of this study suggest that hormonal status may interact with genetic variants to influence cardiovascular phenotypes, specifically, the pharmacogenomic effects within the innate immunity pathway for CIMT.

The calcium inhibitor SR33805 reduces intimal formation following injury of the porcine carotid artery

2001 ◽  
Vol 154 (2) ◽  
pp. 301-308 ◽  
Author(s):  
Patricia Hainaud ◽  
Michel Bonneau ◽  
Georges Pignaud ◽  
Claire Bal dit Sollier ◽  
Patrick André ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Porcine Carotid Artery

scholarly journals Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury

10.3791/57981 ◽  
2018 ◽  
Author(s):  
Allyson L. Huttinger ◽  
Debra G. Wheeler ◽  
Surya Gnyawali ◽  
David Dornbos ◽  
Juliana M. Layzer ◽  
...  
Keyword(s):  
Animal Model ◽  
Carotid Artery ◽  
Vascular Injury ◽  
Ferric Chloride ◽  
Large Animal Model ◽  
Large Animal ◽  
Carotid Artery Thrombosis ◽  
Artery Thrombosis

scholarly journals Postangioplasty restenosis: a practical model in the porcine carotid artery

1997 ◽  
Vol 30 (9) ◽  
pp. 1087-1091 ◽  
Author(s):  
P.R.A. Caramori ◽  
E.E. Eggers ◽  
A.P.F. Silva-Filho ◽  
D.M. Uchoa ◽  
F. Jung ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Practical Model ◽  
Porcine Carotid Artery

Entry of Bilirubin into the Brain Due to Opening of the Blood-Brain Barrier

PEDIATRICS ◽  
1982 ◽  
Vol 69 (3) ◽  
pp. 255-259 ◽  
Author(s):  
Rodney L. Levine ◽  
Wendy R. Fredericks ◽  
Stanley I. Rapoport
Keyword(s):  
Animal Model ◽  
Carotid Artery ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Hypertonic Solution ◽  
Control Side ◽  
Blood Brain ◽  
The Brain

A potential animal model of kernicterus has been developed. The blood-brain barrier was opened on one side of the brain, by brief infusion of a hypertonic solution into the carotid artery. Upon peripheral infusion of bilirubin, the animals developed unilateral yellow staining of the brain: the treated side was stained whereas the control side was not. This cerebral icterus resulted from the entry of albumin-bound bilirubin into the brain, and not from the passage of free bilirubin.

scholarly journals Cardiotoxic effects of pavetamine extracted from Pavetta harborii in the rat

2008 ◽  
Vol 75 (3) ◽  
Author(s):  
L. Hay ◽  
R.A. Schultz ◽  
P.J. Schutte
Keyword(s):  
Heart Failure ◽  
Animal Model ◽  
Carotid Artery ◽  
Plant Material ◽  
Active Component ◽  
Systolic Function ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
The Right ◽  
Induce Heart Failure

Previous studies have shown that crude extracts from Pavetta harborii as well as dried plant material have cardiotoxic effects on rats and sheep that can lead to heart failure. The active component has since been isolated and identified. This substance has been named pavetamine. The aim of this study was to determine whether pavetamine has cardiotoxic effects similar to those seen in previous reports, when administered to rats intraperitoneally. Sprague Dawley rats received two doses, initially 4 mg / kg and then 3 mg / kg pavetamine respectively and were monitored for 35 days before cardiodynamic parameters were measured by inserting a fluid-filled catheter into the left ventricle via the right carotid artery. These values were compared to those of control rats that had received only saline. Pavetamine significantly reduced systolic function and body mass in the treated rats, which indicates that it has the potential to induce heart failure in this animal model.

scholarly journals Variation in electrosurgical vessel seal quality along the length of a porcine carotid artery

2016 ◽  
Vol 230 (3) ◽  
pp. 169-174 ◽  
Author(s):  
Hayley Louise Wyatt ◽  
Rosie Richards ◽  
Rhys Pullin ◽  
TH Jimmy Yang ◽  
Emma J Blain ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Porcine Carotid Artery

scholarly journals Transient Bilateral Common Carotid Artery Occlusion (tBCCAO) of Rats as a Model of Global Cerebral Ischemia

2019 ◽  
Vol 18 (3) ◽  
pp. 491-500
Author(s):  
Ety Sari Handayani ◽  
Rina Susilowati ◽  
Ismail Setyopranoto ◽  
Ginus Partadiredja
Keyword(s):  
Animal Model ◽  
Cerebral Ischemia ◽  
Carotid Artery ◽  
Common Carotid Artery ◽  
Artery Occlusion ◽  
Carotid Artery Occlusion ◽  
Functional Tests ◽  
Ischemic Area ◽  
Bilateral Common Carotid Artery ◽  
Common Carotid Artery Occlusion

Background: Transient bilateral common carotid artery occlusion (tBCCAO) has been performed in rats as a model of global ischemia. However, the technique varied between laboratories and produced difficulties in the comparison of results. Variations such as rat strain, age, ischemic and reperfusion duration could affect the results. This review aims to provide a general overview of the variation of animal strains, duration of tBCCAO, reported cerebral ischemic area produced by tBCCAO, use of TTC staining for measurement of volume of brain ischemia and functional neurological tests. Method: The data of this review were obtained from abstracts in PubMed database and Google Scholars and were not limited by publication time. Keywords used to search the abstracts were (BCCAO OR “bilateral common carotid artery occlusion” OR “stroke” OR “cerebral ischemia” OR “brain ischemia”) AND (rat OR rats). The research method of each study was identified from the collected abstracts. The abstracts were chosen for further study on the basis that they met the inclusion criteria which were English language articles; original research article; animal model used were adolescent, adult, and elderly rats; ischemic finding in rats’ cerebrum by BCCAO technique was presented; ischemic size were assessed and the result was described; studies that had control group; and studies that induced transient global ischemic to the rats’ cerebrum. Data that were extracted to the datasheet were references; animal model strain; ischemic duration; reperfusion duration; ischemic area; 2,3,5 Triphenyltetrazolium Chloride (TTC) staining; Cavalieri method; and rats’ neurological functional tests. Results and Conclusions: There were differences in the ischemic area between Wistar and Sprague-Dawley rats after transient BCCAO. There were differences in the TTC staining solution concentration that was used to identify ischemic area of the brain following transient BCCAO. There was a very limited number of studies using Cavalieri method for the quantification of ischemic volume of rats’ brain after transient BCCAO. Neurological functional tests in animal models post transient BCCAO did not include sensory and memory functions tests. Bangladesh Journal of Medical Science Vol.18(3) 2019 p.491-500

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