How do non-steroidal anti-inflammatory drugs (NSAIDs) compare with corticosteroids for controlling inflammation after uncomplicated cataract surgery?

2019 ◽  
Author(s):  
Jane Burch ◽  
Asaf Achiron
Keyword(s):  
Cataract Surgery ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Topical Nonsteroidal Anti-Inflammatory Drugs in Uncomplicated Cataract Surgery: Effect of Sodium Naproxen

2005 ◽  
Vol 15 (5) ◽  
pp. 598-606 ◽  
Author(s):  
P. Russo ◽  
V. Papa ◽  
S. Russo ◽  
A. Dl Bella ◽  
G. Pabst ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Ophthalmic Solution ◽  
Controlled Study ◽  
Topical Formulation ◽  
Serious Adverse Events ◽  
Suitable Alternative ◽  
Postoperative Inflammation ◽  
Sodium Naproxen ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Purpose To investigate whether topical nonsteroidal anti inflammatory drugs (NSAIDs) are useful, in the absence of concomitant corticosteroid therapy, in limiting postoperative inflammation after uncomplicated cataract surgery. Methods A total of 328 patients were enrolled in a prospective, randomized, double-masked, parallel-group, active-controlled study. Anterior chamber inflammation (ACI) was evaluated as the primary efficacy parameter. Only patients with moderate inflammation (ACI score of ≤4) the day after surgery were randomized and treated with NSAIDs. A novel topical formulation containing 0.2% sodium naproxen was compared with 0.1% diclofenac. Both were administered three times a day for 14 consecutive days. Ocular inflammation was measured after 7 and 14 days by using slit-lamp biomicroscopy. Safety parameters were also evaluated at the same time. Results Both treatments were equally effective in controlling postsurgical inflammation. No statistically significant differences between treatment groups were observed for the safety variables. No serious adverse events (AEs) occurred during the course of the study. The most frequent AE reported with naproxen was eye redness. Conclusions NSAIDs can effectively be used without concurrent administration of corticosteroids to control postoperative inflammation after uncomplicated cataract surgery. In addition, naproxen ophthalmic solution may be considered a suitable alternative to the currently available NSAIDs.

scholarly journals Non-steroidal anti-inflammatory drugs in the post-operative treatment of ophthalmic patients

2015 ◽  
Vol 8 (3) ◽  
pp. 45-48
Author(s):  
Sergey Yurievich Astakhov ◽  
Medeya Vakhtangovna Gobedzhishvili
Keyword(s):  
Cataract Surgery ◽  
Operative Treatment ◽  
Cataract Extraction ◽  
Eye Drops ◽  
Treatment Results ◽  
Before And After ◽  
Inflammatory Processes ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Purpose: to analyze the efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) after cataract extraction. To determine the NSAID’s role in post-operative inflammatory processes treatment. Results: the rationale of NSAIDs use before and after cataract surgery was validated. The NSAIDs efficacy in terms of post-op inflammation reduction was confirmed. Among NSAIDs benefits, the convenient and easy-to-use instillation regimen of Bromfenac 0.09% eye drops solution was highlighted.

Current Use of Non-steroidal Anti-inflammatory Drugs in the Treatment of Ocular Inflammation Related to Cataract Surgery

2012 ◽  
Vol 06 (03) ◽  
pp. 173 ◽  
Author(s):  
Eric Donnenfeld ◽  
Keyword(s):  
Cataract Surgery ◽  
Ocular Inflammation ◽  
Cystoid Macular Oedema ◽  
Effective Management ◽  
Ocular Pain ◽  
Reduction Of Pain ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Systemic Responses ◽  
Topical Nsaids

Ocular inflammation and pain are a common consequence of cataract surgery, and if left untreated, may lead to extensive ocular damage, resulting in impaired vision as well as decreased satisfaction with the procedure. Effective management of ophthalmic inflammation after surgery is therefore vital. Topical ophthalmic non-steroidal anti-inflammatory drugs (NSAIDs) have become a mainstay of management of ocular pain and inflammation as a result of their anti-inflammatory activity, analgesic property and established safety record. Numerous studies have demonstrated the efficacy of topical NSAIDs in post-operative prevention of ocular inflammation, inhibition of intra-operative miosis, reduction of pain associated with cataract surgery and pre-operative use to prevent cystoid macular oedema. Studies have also indicated that NSAIDs and steroids act synergistically when administered together, and that a combination of steroid and NSAID therapy is recommended to achieve successful outcomes. With appropriate administration, NSAIDs are safe and effective therapeutic agents, which rarely result in serious local and systemic responses.

Perioperative Topical Nonsteroidal Anti-inflammatory Drugs for Macular Edema Prophylaxis Following Cataract Surgery

2017 ◽  
Vol 176 ◽  
pp. 174-182 ◽  
Author(s):  
Bobeck S. Modjtahedi ◽  
John F. Paschal ◽  
Michael Batech ◽  
Tiffany Q. Luong ◽  
Donald S. Fong
Keyword(s):  
Cataract Surgery ◽  
Macular Edema ◽  
Inflammatory Drugs ◽  
Anti Inflammatory
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