Tripartite motif protein 52 (TRIM52) promoted fibrosis in LX‐2 cells through PPM1A‐mediated Smad2/3 pathway

2019 ◽  
Vol 44 (1) ◽  
pp. 108-116
Author(s):  
Ju Zhou ◽  
Qing Lan ◽  
Wu Li ◽  
Lin Yang ◽  
Jing You ◽  
...  
Keyword(s):  
Tripartite Motif ◽  
Tripartite Motif Protein

scholarly journals HMGB1 orchestrates STING-mediated senescence via TRIM30α modulation in cancer cells

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Je-Jung Lee ◽  
In Ho Park ◽  
Man Sup Kwak ◽  
Woo Joong Rhee ◽  
Songhee H. Kim ◽  
...  
Keyword(s):  
High Mobility ◽  
Dependent Manner ◽  
Signal Transducer ◽  
Therapeutic Concept ◽  
Doxorubicin Treatment ◽  
Tripartite Motif ◽  
Anticancer Mechanism ◽  
Tripartite Motif Protein ◽  
Underlying Mechanisms ◽  
Novel Therapeutic

AbstractAlthough cellular senescence has emerged as a novel therapeutic concept in cancer, its underlying mechanisms remain unclear. High mobility group box 1 (HMGB1) and stimulator of interferon genes (STING) are involved in senescence. However, their interactions in senescence have not been reported. Therefore, in this study, we investigated the relationships between HMGB1 and STING in senescence in cancer and other cells. In mouse melanoma cells and several other cell lines, doxorubicin treatment induced senescence in an HMGB1-dependent manner. These responses were mediated by STING, and this function of STING was negatively regulated by the E3 ligase tripartite motif protein 30α (TRIM30α). We also found that HMGB1 bound to the TRIM30α promoter and then suppressed its expression by inhibiting its transcription, which enhanced STING-induced senescence. This mechanism was further mediated by signal transducer and activator of transcription 6 (STAT6) and p21. Overall, our findings demonstrated that HMGB1 orchestrated STING-STAT6-p21-mediated senescence by regulating TRIM30α as an alternative anticancer mechanism.

scholarly journals Tripartite Motif Protein 32 Facilitates Cell Growth and Migration via Degradation of Abl-Interactor 2

2008 ◽  
Vol 68 (14) ◽  
pp. 5572-5580 ◽  
Author(s):  
Satoshi Kano ◽  
Naoto Miyajima ◽  
Satoshi Fukuda ◽  
Shigetsugu Hatakeyama
Keyword(s):  
Cell Growth ◽  
Cell Growth And Migration ◽  
Tripartite Motif ◽  
Tripartite Motif Protein ◽  
And Migration

scholarly journals Human tripartite motif protein 52 is required for cell context-dependent proliferation

Oncotarget ◽  
2018 ◽  
Vol 9 (17) ◽  
pp. 13565-13581 ◽  
Author(s):  
Stefan Benke ◽  
Benedikt Agerer ◽  
Lisa Haas ◽  
Martin Stöger ◽  
Alexander Lercher ◽  
...  
Keyword(s):  
Tripartite Motif ◽  
Tripartite Motif Protein ◽  
Context Dependent

scholarly journals The ubiquitin ligase tripartite-motif-protein 32 is induced in Duchenne muscular dystrophy

2016 ◽  
Vol 96 (8) ◽  
pp. 862-871 ◽  
Author(s):  
Stefania Assereto ◽  
Rosanna Piccirillo ◽  
Serena Baratto ◽  
Paolo Scudieri ◽  
Chiara Fiorillo ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Ubiquitin Ligase ◽  
Tripartite Motif ◽  
Tripartite Motif Protein
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