scholarly journals Molecular Characterization and Expression Pattern of Tripartite Motif Protein 39 in Gallus gallus with a Complete PRY/SPRY Domain

2011 ◽  
Vol 12 (6) ◽  
pp. 3797-3809 ◽  
Author(s):  
Chunqing Pan ◽  
Heng Zhao ◽  
Lin Shen ◽  
Jiping Sheng
Keyword(s):  
Molecular Characterization ◽  
Expression Pattern ◽  
Gallus Gallus ◽  
Spry Domain ◽  
Tripartite Motif ◽  
Tripartite Motif Protein

Molecular characterization of Rhodeus uyekii tripartite motif protein 1 (TRIM1) involved in IFN-γ/LPS-induced NF-κB signaling

2018 ◽  
Vol 79 ◽  
pp. 42-51 ◽  
Author(s):  
Julan Kim ◽  
Ju-Won Kim ◽  
Dong-Gyun Kim ◽  
Bo-Hye Nam ◽  
Young-Ok Kim ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Tripartite Motif ◽  
Ifn Γ ◽  
Tripartite Motif Protein ◽  
Rhodeus Uyekii

scholarly journals HMGB1 orchestrates STING-mediated senescence via TRIM30α modulation in cancer cells

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Je-Jung Lee ◽  
In Ho Park ◽  
Man Sup Kwak ◽  
Woo Joong Rhee ◽  
Songhee H. Kim ◽  
...  
Keyword(s):  
High Mobility ◽  
Dependent Manner ◽  
Signal Transducer ◽  
Therapeutic Concept ◽  
Doxorubicin Treatment ◽  
Tripartite Motif ◽  
Anticancer Mechanism ◽  
Tripartite Motif Protein ◽  
Underlying Mechanisms ◽  
Novel Therapeutic

AbstractAlthough cellular senescence has emerged as a novel therapeutic concept in cancer, its underlying mechanisms remain unclear. High mobility group box 1 (HMGB1) and stimulator of interferon genes (STING) are involved in senescence. However, their interactions in senescence have not been reported. Therefore, in this study, we investigated the relationships between HMGB1 and STING in senescence in cancer and other cells. In mouse melanoma cells and several other cell lines, doxorubicin treatment induced senescence in an HMGB1-dependent manner. These responses were mediated by STING, and this function of STING was negatively regulated by the E3 ligase tripartite motif protein 30α (TRIM30α). We also found that HMGB1 bound to the TRIM30α promoter and then suppressed its expression by inhibiting its transcription, which enhanced STING-induced senescence. This mechanism was further mediated by signal transducer and activator of transcription 6 (STAT6) and p21. Overall, our findings demonstrated that HMGB1 orchestrated STING-STAT6-p21-mediated senescence by regulating TRIM30α as an alternative anticancer mechanism.

Molecular characterization, expression pattern, and function analysis of the OsBC1L family in rice

2009 ◽  
Vol 71 (4-5) ◽  
pp. 469-481 ◽  
Author(s):  
Xiaoxia Dai ◽  
Changjun You ◽  
Lei Wang ◽  
Guoxing Chen ◽  
Qifa Zhang ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Expression Pattern ◽  
Function Analysis ◽  
And Function
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