scholarly journals Modulation of mitochondrial metabolism as a biochemical trait in blood feeding organisms: the redox vampire hypothesis redux

2018 ◽  
Vol 42 (6) ◽  
pp. 683-700 ◽  
Author(s):  
Caroline M. Ferreira ◽  
Matheus P. Oliveira ◽  
Marcia C. Paes ◽  
Marcus F. Oliveira
Keyword(s):  
Blood Feeding ◽  
Mitochondrial Metabolism ◽  
Biochemical Trait

Hemolysis of erythrocytes by the hemolytic system from the blood-feeding stable fly, Stomoxys calcitrans

1992 ◽  
Vol 50 (1) ◽  
pp. 690-691
Author(s):  
H. J. Kirch ◽  
G. Spates ◽  
R. Droleskey ◽  
W.J. Kloft ◽  
J.R. DeLoach
Keyword(s):  
Blood Feeding ◽  
Stomoxys Calcitrans ◽  
Stable Fly ◽  
Digestive Physiology ◽  
Transmission Electron ◽  
Erythrocyte Lysis ◽  
Mammalian Blood ◽  
Bovine Erythrocytes ◽  
Potential Tool

Blood feeding insects have to rely on the protein content of mammalian blood to insure reproduction. A substantial quantity of protein is provided by hemoglobin present in erythrocytes. Access to hemoglobin is accomplished only via erythrocyte lysis. It has been shown that midgut homogenates from the blood feeding stable fly, Stomoxys calcitrans, contain free fatty acids and it was proposed that these detergent-like compounds play a major role as hemolysins in the digestive physiology of this species. More recently sphingomyelinase activity was detected in midgut preparations of this fly, which would provide a potential tool for the enzymatic cleavage of the erythrocyte's membrane sphingomyelin. The action of specific hemolytic factors should affect the erythrocyte's morphology. The shape of bovine erythrocytes undergoing in vitro hemolysis by crude midgut homogenates from the stable fly was examined by scanning and transmission electron microscopy.

Exenatide Treatment Improves Mitochondrial Metabolism and Hepatic Insulin Sensitivity in Mice with Nonalcoholic Steatohepatitis (NASH)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1846-P
Author(s):  
SRILAXMI KALAVALAPALLI ◽  
FERNANDO BRIL ◽  
ARIANA VERGARA ◽  
NISHANTH SUNNY ◽  
KENNETH CUSI
Keyword(s):  
Insulin Sensitivity ◽  
Nonalcoholic Steatohepatitis ◽  
Mitochondrial Metabolism ◽  
Hepatic Insulin Sensitivity

288-LB: Effects of the Hepatic Mitochondrial Calcium Uniporter on Hepatic Gluconeogenesis and Mitochondrial Metabolism in Awake Mice

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 288-LB
Author(s):  
JI EUN LEE ◽  
LEIGH GOEDEKE ◽  
YE ZHANG ◽  
RACHEL J. PERRY ◽  
RUSSELL GOODMAN ◽  
...  
Keyword(s):  
Mitochondrial Metabolism ◽  
Mitochondrial Calcium ◽  
Hepatic Gluconeogenesis ◽  
Mitochondrial Calcium Uniporter ◽  
Calcium Uniporter

Medical Therapeutics Derived from Leeches (Phy. Annelida; Cl. Hirudinea)

2016 ◽  
Vol 3 (1) ◽  
Author(s):  
Christopher Everett Warren Clarke
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Heart Attack ◽  
Blood Feeding ◽  
Vascular Trauma ◽  
Biological Molecules ◽  
Future Treatment ◽  
Medical Therapeutics

Of all blood feeding invertebrates, few are more notorious than leeches. Throughout their existence as ectoparasites, leeches have evolved to release biological molecules in their saliva that act to counter the responses of the prey’s body to vascular trauma. Inadvertently, these very molecules have been used by humans for centuries for medicinal purposes; however, it is only recently that their cellular action has been elucidated. As a result, these compounds have been isolated and mass produced to treat a wide variety of conditions ranging from heart attack to Alzheimer’s disease and continued work suggests that these isolates will be an important future treatment for metastasis.

Mitochondrial metabolism, reactive oxygen species, and macrophage function-fishing for insights

2014 ◽  
Vol 92 (11) ◽  
pp. 1119-1128 ◽  
Author(s):  
Christopher J. Hall ◽  
Leslie E. Sanderson ◽  
Kathryn E. Crosier ◽  
Philip S. Crosier
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Mitochondrial Metabolism ◽  
Oxygen Species ◽  
Macrophage Function
Sign in / Sign up

Export Citation Format

Share Document