Glycometabolic reprogramming associated with the initiation of human dental pulp stem cell differentiation

2015 ◽  
Vol 40 (3) ◽  
pp. 308-317 ◽  
Author(s):  
Linyan Wang ◽  
Li Cheng ◽  
Huning Wang ◽  
Hongying Pan ◽  
Hui Yang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Dental Pulp ◽  
Stem Cell Differentiation ◽  
Human Dental Pulp ◽  
Dental Pulp Stem Cell

Photobiomodulatory effect delivered by low-level laser on dental pulp stem cell differentiation for osteogenic lineage

2019 ◽  
Vol 3 (3) ◽  
pp. 175-181 ◽  
Author(s):  
Trivandrum T. Sivakumar ◽  
Alex M. Muruppel ◽  
Anna P. Joseph ◽  
A. Reshmi ◽  
Rajesh Ramachandran ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Dental Pulp ◽  
Stem Cell Differentiation ◽  
Low Level ◽  
Low Level Laser ◽  
Osteogenic Lineage ◽  
Level Laser ◽  
Dental Pulp Stem Cell

C5a complement receptor modulates odontogenic dental pulp stem cell differentiation under hypoxia

2021 ◽  
pp. 1-10
Author(s):  
Ryan Pasiewicz ◽  
Yessenia Valverde ◽  
Raghuvaran Narayanan ◽  
Ji-Hyun Kim ◽  
Muhammad Irfan ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Dental Pulp ◽  
Stem Cell Differentiation ◽  
Complement Receptor ◽  
Dental Pulp Stem Cell

Comparison of ganglioside expression between human adipose- and dental pulp-derived stem cell differentiation into osteoblasts

2010 ◽  
Vol 33 (4) ◽  
pp. 585-591 ◽  
Author(s):  
So Hyun Lee ◽  
Jae-Sung Ryu ◽  
Jeong-Woong Lee ◽  
Dong Hoon Kwak ◽  
Kisung Ko ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Dental Pulp ◽  
Stem Cell Differentiation ◽  
Ganglioside Expression

scholarly journals Alginate/Pluronic F127-based encapsulation supports viability and functionality of human dental pulp stem cell-derived insulin-producing cells

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Suryo Kuncorojakti ◽  
Watchareewan Rodprasert ◽  
Supansa Yodmuang ◽  
Thanaphum Osathanon ◽  
Prasit Pavasant ◽  
...  
Keyword(s):  
Stem Cell ◽  
Dental Pulp ◽  
Pluronic F127 ◽  
Insulin Producing Cells ◽  
Human Dental Pulp ◽  
Dental Pulp Stem Cell

scholarly journals Macrophage modulation of dental pulp stem cell activity during tertiary dentinogenesis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Vitor C. M. Neves ◽  
Val Yianni ◽  
Paul T. Sharpe
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Immune Cells ◽  
Dental Pulp ◽  
Cell Activation ◽  
Cell Activity ◽  
Stem Cell Differentiation ◽  
Dental Pulp Stem Cell ◽  
Anti Inflammatory

AbstractThe interaction between immune cells and stem cells is important during tissue repair. Macrophages have been described as being crucial for limb regeneration and in certain circumstances have been shown to affect stem cell differentiation in vivo. Dentine is susceptible to damage as a result of caries, pulp infection and inflammation all of which are major problems in tooth restoration. Characterising the interplay between immune cells and stem cells is crucial to understand how to improve natural repair mechanisms. In this study, we used an in vivo damage model, associated with a macrophage and neutrophil depletion model to investigate the role of immune cells in reparative dentine formation. In addition, we investigated the effect of elevating the Wnt/β-catenin pathway to understand how this might regulate macrophages and impact upon Wnt receiving pulp stem cells during repair. Our results show that macrophages are required for dental pulp stem cell activation and appropriate reparative dentine formation. In addition, pharmacological stimulation of the Wnt/β-catenin pathway via GSK-3β inhibitor small molecules polarises macrophages to an anti-inflammatory state faster than inert calcium silicate-based materials thereby accelerating stem cell activation and repair. Wnt/β-catenin signalling thus has a dual role in promoting reparative dentine formation by activating pulp stem cells and promoting an anti-inflammatory macrophage response.

Sign in / Sign up

Export Citation Format

Share Document