Characteristics of Notch2+pancreatic cancer stem-like cells and the relationship with centroacinar cells

2013 ◽  
Vol 37 (8) ◽  
pp. 805-811 ◽  
Author(s):  
Zhu-Chao Zhou ◽  
Qiang-Gang Dong ◽  
De-liang Fu ◽  
Yi-yi Gong ◽  
Quan-Xing Ni
Keyword(s):  
Pancreatic Cancer ◽  
The Relationship ◽  
Centroacinar Cells

scholarly journals The significance of exosomal RNAs in the development, diagnosis, and treatment of pancreatic cancer

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zheng Zhao ◽  
Guiping Zhao ◽  
Shuyue Yang ◽  
Shengtao Zhu ◽  
Shutian Zhang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Immune Escape ◽  
Diagnosis And Treatment ◽  
Circular Rnas ◽  
Molecular Heterogeneity ◽  
Bioactive Constituents ◽  
Functional Connections ◽  
Non Coding Rnas ◽  
The Relationship ◽  
Exosomal Rnas

AbstractExosomes are single-membrane, secreted organelles with a diameter of 30–200 nm, containing diverse bioactive constituents, including DNAs, RNAs, proteins, and lipids, with prominent molecular heterogeneity. Extensive studies indicate that exosomal RNAs (e.g., microRNAs, long non-coding RNAs, and circular RNAs) can interact with many types of cancers, associated with several hallmark features like tumor growth, metastasis, and resistance to therapy. Pancreatic cancer (PaCa) is among the most lethal cancers worldwide, emerging as the seventh foremost cause of cancer-related death in both sexes. Hence, revealing the specific pathogenesis and improving the clinical diagnosis and treatment process are urgently required. As the study of exosomes has become an active area of research, the functional connections between exosomes and PaCa have been deeply investigated. Among these, exosomal RNAs seem to play a significant role in the development, diagnosis, and treatment of PaCa. Exosomal RNAs delivery ultimately modulates the various features of PaCa, and many scholars have interpreted how exosomal RNAs contribute to the proliferation, angiogenesis, migration, invasion, metastasis, immune escape, and drug resistance in PaCa. Besides, recent studies emphasize that exosomal RNAs may serve as diagnostic and prognostic biomarkers or therapeutic targets for PaCa. In this review, we will introduce these recent insights focusing on the discoveries of the relationship between exosomal RNAs and PaCa, and the potentially diagnostic and therapeutic applications of exosomes in PaCa.

scholarly journals Influence of Diet and Tobacco Smoking on Pancreatic Cancer Incidence in Poland in 1960–2008

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Mirosław Jarosz ◽  
Włodzimierz Sekuła ◽  
Ewa Rychlik
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Incidence ◽  
Tobacco Smoking ◽  
Red Meat ◽  
Incidence Rates ◽  
Dietary Factors ◽  
Balance Sheets ◽  
Animal Fats ◽  
The Relationship ◽  
Cancer Incidence Rates

The aim of the study was to investigate the relationship between pancreatic cancer incidence and selected dietary factors, alcohol consumption, and tobacco smoking in Poland in 1960–2008. Data on pancreatic cancer morbidity were derived from the National Cancer Registry and on food consumption from the national food balance sheets. In 1960–1989 correlations were found between pancreatic cancer incidence rates and energy (0.60 for males and 0.57 for females), cholesterol (0.87 and 0.80), fibre (−0.84 and −0.89) and folate (−0.45 and −0.49) intake, the consumption of total fats (0.94 and 0.91), animal fats (0,90 and 0,82), sugar (0.88 and 0.87), cereals (−0.93 and −0.91), and alcohol (0.86 and 0.82). In 1990–2008 morbidity correlated with the consumption of red meat (0.67 and 0.48), poultry (−0.88 and −0.57), and fruit (−0.62 and −0.50). Correlation with tobacco smoking was observed in the whole studied period (0.55 and 0.44). Increased incidence of pancreatic cancer in 1960–1995 was probably related to adverse dietary patterns up to 1989, especially high consumption of fats, sugar, and alcohol. Further positive changes in the diet such as lowering red meat consumption and increasing fruit consumption could influence incidence reduction in recent years. Also changes in tobacco smoking could affect the morbidity.

scholarly journals A Misleading Case of Hepatic Echinococcosis

2020 ◽  
Vol 17 (4) ◽  
pp. 87-93
Author(s):  
Laura-Maria Manea ◽  
Alexandra Jichitu ◽  
Vlad Pînzariu ◽  
Nicoleta Mihaela Sprîncenatu Irina Iuliana ◽  
Mariana Anton ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Eastern Europe ◽  
Hydatid Disease ◽  
Hepatic Metastases ◽  
Zoonotic Disease ◽  
True Nature ◽  
The Relationship ◽  
Hepatic Echinococcosis

AbstractHydatid disease is a zoonotic disease endemic in Eastern Europe, being highly prevalent in Romania. There are some links between echinococcosis and cancer, but the true nature of the relationship between these diseases remains to be established. We present the case of a 49-year-old male with hepatic echinococcosis and concomitant hepatic metastases of a previously undiagnosed pancreatic cancer.

scholarly journals Substantiation of connection between affective disorders and development of malignant neoplasms of pancreas: experience of the center

2021 ◽  
Vol 38 (2) ◽  
pp. 14-22
Author(s):  
V. E. Moiseenko ◽  
Izeta G. Kardanova ◽  
A. V. Pavlovsky ◽  
D. A. Granov ◽  
G. V. Rukavishnikov ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Affective Disorders ◽  
Early Stage ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Malignant Neoplasms ◽  
European Organization ◽  
Screening Programs ◽  
Russian Version ◽  
The Relationship

Objective. To analyze the relationship between the affective disorders in the form of anxiety and depression and the development of pancreatic cancer and stomach cancer. Today, there is an interest to the relationship between changes in the emotional sphere of patients with malignant neoplasms (MNO) of the pancreas at the early stages of the disease, when there are no other clinically significant symptoms, which allow suspecting the disease at an early stage. Materials and methods. A questionnaire survey was carried out in 63 patients with histologically verified cancer of the pancreas and stomach, who were treated at the FGBU RNTSRKhT named after Acad. A.M. Granov in the period from 2018 to 2020. The survey was conducted using the questionnaire of the European Organization for Research and Treatment of Cancer (EORTC-QLQ-C30 Russian version) and the Hospital Anxiety and Depression Scale (HADS), Russian version. Statistical processing of treatment results was carried out using regression analysis and Mann-Whitney test with the SPSS statistical software package (Statistika 13.0). The probability of error p 0.05 was considered sufficient to conclude that the differences in the data obtained were statistically significant. Results. In a comparative assessment of the indicators of affective disorders in pancreatic cancer patients, there were noted more pronounced affective disorders, such as feeling of depression, feeling of irritation, anxiety and tension, the values of which, according to the results of the analysis of questionnaires, were 1.00 1, 1, 00 1.00 1 and 2.00 1, respectively. In patients with gastric cancer, the values of these affective disorders, according to the survey results, were less pronounced and amounted to 3.00 1.00 1.00, 3.00 1.00, 3.00 1, respectively (p = 0.000). Conclusions. Severe affective disorders, such as anxiety and depression, in patients with pancreatic cancer should be regarded as a factor of the early manifestation of the disease. Further study of this connection can create a theoretical basis for the development of specialized screening programs to identify patients in the risk groups for the development of pancreatic cancer.

Correlation of bone marrow micrometastases with nodal status in gastrointestinal tumors

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 14577-14577
Author(s):  
S. Chivu ◽  
S. Saha ◽  
G. M. Patel ◽  
D. Wiese ◽  
N. Bassily ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Pancreatic Cancer ◽  
Bone Marrow ◽  
Imaging System ◽  
Nodal Status ◽  
Nodal Metastases ◽  
Posterior Superior Iliac Spine ◽  
Clinical Value ◽  
Bone Marrow Micrometastases ◽  
The Relationship

14577 Background: Presence of bone marrow micrometastases (BMM) is an important prognostic factor for patients (pts) with solid tumors. Sentinel lymph node (SLN) mapping (M) has been found to upstage pts with gastrointestinal (GI) malignancies. However, a direct correlation between the presence BMM and nodal metastases (mets) is lacking. Hence, a retrospective study was undertaken to determine the relationship between BMM and nodal status in various GI malignancies. Methods: A total of 159 consecutive pts with GI malignancies were analyzed. Of these, 6 pts with non-epithelial tumors were excluded. All pts underwent bilateral posterior-superior-iliac spine bone marrow (BM) aspiration. BM samples were examined for micrometastases by Automated Cellular Imaging System using ChromaVision Cytokeratin Detection Kit to detect cells expressing CK8 as defined by CAM 5.2 monoclonal antibody. When feasible, SLNM was performed followed by standard oncologic resection (n=105). The SLN were examined by H&E and immunohistochemical (IHC) staining. Results: A total of 153 pts were analyzed in the study. Of these 13.72% (21/153) were found to have BMM (CI 8.70–20.21, p=0.05). When analyzed by sites, the incidence of BMM was 33.3% (4/12) for stomach cancer, 9.1% (1/11) for pancreatic cancer, 12.36% (11/89) for colon cancer and 16.13% (5/31) for rectal cancer. No BMM were detected in pts with cancer of esophagus (n=7), small bowel (n=2) and liver (n=1). The BMM was positive bilaterally in 61.9% (13/21), and unilaterally in 38.1% (8/21). In pts who underwent SLNM (n=105), BMM were detected in 11.11% of SLN positive pts vs. 10.14% for SLN negative pts (p=0.87). For a subgroup of pts with colorectal cancer who underwent SLNM (n=97), BMM were detected in 9.67% of SLN positive pts vs. 9.09% for SLN negative pts (p=0.92) Conclusions: BMM did not correlate with nodal status for GI malignancies suggesting a possible different mechanism for metastases. Detection of BMM may have a significant clinical value in SLN negative pts who may benefit from adjuvant therapy. [Table: see text] No significant financial relationships to disclose.

The relationship between multiple clinicopathological features and nerve invasion in pancreatic cancer

2013 ◽  
Vol 12 (5) ◽  
pp. 546-551 ◽  
Author(s):  
Pao-Hsun Wang ◽  
Ning Song ◽  
Liu-Bin Shi ◽  
Qun-Hua Zhang ◽  
Zong-You Chen
Keyword(s):  
Pancreatic Cancer ◽  
Clinicopathological Features ◽  
Nerve Invasion ◽  
The Relationship

scholarly journals MELODI - Mining Enriched Literature Objects to Derive Intermediates

2017 ◽  
Author(s):  
Benjamin Elsworth ◽  
Karen Dawe ◽  
Emma E Vincent ◽  
Ryan Langdon ◽  
Brigid M Lynch ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Pancreatic Cancer ◽  
Web Application ◽  
Scientific Literature ◽  
Literature Mining ◽  
Analytical Evaluation ◽  
Disease Mechanisms ◽  
The Relationship ◽  
Published Research

AbstractMotivationThe scientific literature contains a wealth of information from different fields on potential disease mechanisms. However, prioritising mechanisms for further analytical evaluation presents enormous challenges in terms of the quantity and diversity of published research. The application of data mining approaches to the literature offers the potential to identify and prioritise mechanisms for more focused and detailed analysis.ResultsHere we present MELODI, a literature mining platform that can identify mechanistic pathways between any two biomedical concepts. Two case studies demonstrate the potential uses of MELODI and how it can generate hypotheses for further investigation. Firstly, an analysis of ERG and prostate cancer derives the intermediate transcription factor SP1, recently confirmed to be physically interacting with ERG. Secondly, examining the relationship between a new potential risk factor for pancreatic cancer identifies possible mechanistic insights which can be studiedin vitro.AvailabilityMELODI has been implemented as a Python/Django web application, and is freely available to use [email protected]

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