Ligand binding to dynamically populated G‐quadruplex DNA

ChemBioChem ◽  
2021 ◽  
Author(s):  
Victoria Birkedal ◽  
Mikayel Aznauryan ◽  
Sofie Louise Noer ◽  
Camilla W. Pedersen ◽  
Jean-Louis Mergny ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Quadruplex Dna ◽  
G Quadruplex

scholarly journals Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology

2020 ◽  
Vol 56 (38) ◽  
pp. 5186-5189 ◽  
Author(s):  
Michael P. O’Hagan ◽  
Javier Ramos-Soriano ◽  
Susanta Haldar ◽  
Sadiyah Sheikh ◽  
Juan C. Morales ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Visible Light ◽  
Binding Mode ◽  
Quadruplex Dna ◽  
G Quadruplex

A pyridinium-decorated photoresponsive dithienylethene selectively targets G-quadruplex DNA, allowing binding mode and toxicity to be controlled exclusively with visible light.

scholarly journals NovelFeIIandCoIIComplexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex DNA

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Yi-ning Zhong ◽  
Yan Zhang ◽  
Yun-qiong Gu ◽  
Shi-yun Wu ◽  
Wen-ying Shen ◽  
...  
Keyword(s):  
Natural Products ◽  
Ligand Binding ◽  
Single Crystal ◽  
Natural Product ◽  
Significant Interaction ◽  
Rational Design ◽  
X Ray Diffraction ◽  
Quadruplex Dna ◽  
X Ray ◽  
G Quadruplex

Tryptanthrin is one of the most important members of indoloquinoline alkaloids. We obtained this alkaloid fromIsatis. Two novelFeIIandCoIIcomplexes of tryptanthrin were first synthesized. Single-crystal X-ray diffraction analyses show that these complexes display distorted four-coordinated tetrahedron geometry via two heterocyclic nitrogen and oxygen atoms from tryptanthrin ligand. Binding with G-quadruplex DNA properties revealed that both complexes were found to exhibit significant interaction with G-quadruplex DNA. This study may potentially serve as the basis of future rational design of metal-based drugs from natural products that target the G-quadruplex DNA.

Polymorphism of human telomeric quadruplexes with drugs: a multi-technique biophysical study

2020 ◽  
Vol 22 (20) ◽  
pp. 11583-11592
Author(s):  
L. Comez ◽  
F. Bianchi ◽  
V. Libera ◽  
M. Longo ◽  
C. Petrillo ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Biophysical Study ◽  
Biophysical Method

A multi-technique biophysical method is used to study the ligand binding to G-quadruplex DNA.

Ligand-induced conformational preorganization of loops of c-MYC G-quadruplex DNA and its implications in structure-specific drug design

2017 ◽  
Vol 13 (8) ◽  
pp. 1458-1468 ◽  
Author(s):  
S. Harikrishna ◽  
Saikiran Kotaru ◽  
P. I. Pradeepkumar
Keyword(s):  
Drug Design ◽  
Ligand Binding ◽  
Small Molecules ◽  
Conformational Changes ◽  
Specific Drug ◽  
Quadruplex Dna ◽  
G Quadruplex

Ligand binding toc-MYCG-quadruplex DNA induces conformational changes in the loops of the quadruplex.c-MYCquadruplex-specific small molecules can be designed by targeting these loop conformers.

scholarly journals Mechanistic insight into ligand binding to G-quadruplex DNA

2014 ◽  
Vol 42 (9) ◽  
pp. 5447-5455 ◽  
Author(s):  
Francesco Saverio Di Leva ◽  
Ettore Novellino ◽  
Andrea Cavalli ◽  
Michele Parrinello ◽  
Vittorio Limongelli
Keyword(s):  
Ligand Binding ◽  
Quadruplex Dna ◽  
Mechanistic Insight ◽  
G Quadruplex ◽  
Insight Into

scholarly journals G-quadruplex DNA and ligand interaction in living cells using NMR spectroscopy

2015 ◽  
Vol 6 (6) ◽  
pp. 3314-3320 ◽  
Author(s):  
Gilmar F. Salgado ◽  
Christian Cazenave ◽  
Abdelaziz Kerkour ◽  
Jean-Louis Mergny
Keyword(s):  
Nucleic Acid ◽  
Nmr Spectroscopy ◽  
Ligand Binding ◽  
Living Cells ◽  
Ligand Interaction ◽  
Quadruplex Dna ◽  
G Quadruplex

Using in-cell NMR spectroscopy to probe ligand binding to a G-quadruplex nucleic acid.

Ligand binding to G-quadruplex DNA: new insights from ultraviolet resonance Raman spectroscopy

2020 ◽  
Vol 22 (15) ◽  
pp. 8128-8140 ◽  
Author(s):  
Silvia Di Fonzo ◽  
Jussara Amato ◽  
Federica D’Aria ◽  
Marco Caterino ◽  
Francesco D’Amico ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Raman Scattering ◽  
Ligand Binding ◽  
Resonance Raman Spectroscopy ◽  
Resonance Raman ◽  
Resonance Raman Scattering ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Ultraviolet Resonance Raman Spectroscopy ◽  
Ultraviolet Resonance Raman

Polarized ultraviolet resonance Raman scattering at 266 nm was used to investigate the interaction of BRACO-19 and Pyridostatin with G-quadruplexes having different structural conformations.

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