scholarly journals 2-Methoxypyridine as a Thymidine Mimic in Watson-Crick Base Pairs of DNA and PNA: Synthesis, Thermal Stability, and NMR Structural Studies

ChemBioChem ◽  
2017 ◽  
Vol 18 (21) ◽  
pp. 2165-2170 ◽  
Author(s):  
Irina Novosjolova ◽  
Scott D. Kennedy ◽  
Eriks Rozners
Keyword(s):  
Thermal Stability ◽  
Structural Studies ◽  
Base Pairs ◽  
Pna Synthesis

Structural studies of the Msx-1 homeodomain–DNA complex I

1999 ◽  
Vol 55 (12) ◽  
pp. 2039-2040
Author(s):  
Stacy DeWees ◽  
James H. Geiger
Keyword(s):  
Dna Binding ◽  
Structural Studies ◽  
Hanging Drop ◽  
Unit Cell Parameters ◽  
Orthorhombic Space Group ◽  
Base Pairs ◽  
Cell Parameters ◽  
Dna Binding Specificity ◽  
Peg 4000 ◽  
Dna Complex

Crystals of the Msx-1 homeodomain–DNA complex have been obtained by hanging-drop vapor diffusion at 293 K in 12% PEG 4000 and 0.1 M sodium acetate pH 4.6. The homeodomain consists of 60 amino acids and is the DNA-binding domain. The DNA in the complex was 16 base pairs with the sequence 5′-TGTCACTAATTGAAGG-3′, containing an overhang T at each end. The crystals diffract to 2.15 Å (99.8% completeness) using cryogenic (123 K) conditions. The crystals belong to the orthorhombic space group P212121, with unit-cell parameters a = 33.66, b = 60.96, c = 83.37 Å. The structure will illuminate the details of Msx-1–DNA binding specificity and clarify its role in transcriptional regulation. Mutations in Msx-1 cause craniofacial deformities in mice.

NMR structural studies on a nonnatural deoxyribonucleoside which mediates recognition of GC base pairs in pyrimidine.cntdot.purine.cntdot.pyrimidine DNA triplexes

Biochemistry ◽  
1993 ◽  
Vol 32 (41) ◽  
pp. 11228-11234 ◽  
Author(s):  
Ishwar Radhakrishnan ◽  
Dinshaw J. Patel ◽  
E. Scott Priestley ◽  
Huw M. Nash ◽  
Peter B. Dervan
Keyword(s):  
Structural Studies ◽  
Base Pairs ◽  
Dna Triplexes

Structural studies of DNA gyrase

1984 ◽  
Vol 42 ◽  
pp. 164-167
Author(s):  
T. Kirchhausen ◽  
J. Wang ◽  
S. C. Harrison
Keyword(s):  
Microscopic Study ◽  
Dna Gyrase ◽  
Staphylococcal Nuclease ◽  
Dependent Manner ◽  
Type Ii ◽  
Structural Studies ◽  
Electron Microscopic ◽  
Base Pairs ◽  
Gyrase A ◽  
Negative Supercoils

DNA gyrase, a prokaryotic type II topoisomerase, can introduce negative supercoils into DNA in an ATP-dependent manner and relax negative supercoils in the absence of ATP. Gyrase is a tetramer of two A subunits (MW 105,000) and two B subunits (MW 95,000), and it interacts with about 140 base pairs of DNA (based on staphylococcal nuclease and DNase I protection experiments). We have undertaken an electron microscopic study of gyrase and its binding to DNA, in order to determine how DNA wraps in its complex with the protein.

Dibenzylzirconium Complexes of Chelating Aminodiolates. Synthesis, Structural Studies, Thermal Stability, and Insertion Chemistry

2000 ◽  
Vol 19 (4) ◽  
pp. 509-520 ◽  
Author(s):  
Pengcheng Shao ◽  
Roland A. L. Gendron ◽  
David J. Berg ◽  
Gordon W. Bushnell
Keyword(s):  
Thermal Stability ◽  
Structural Studies

scholarly journals Electronic structural studies on the improved thermal stability of Li(Ni0.8Co0.15Al0.05)O2 by ZrO2 coating for lithium ion batteries

2017 ◽  
Vol 47 (5) ◽  
pp. 565-572 ◽  
Author(s):  
Ji-Young Kim ◽  
Sang Hoon Kim ◽  
Dong Hyun Kim ◽  
Dieky Susanto ◽  
Se Young Kim ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Lithium Ion Batteries ◽  
Lithium Ion ◽  
Structural Studies ◽  
Zro2 Coating ◽  
Thermal Stability Of
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