Role of the Chemical Environment beyond the Coordination Site: Structural Insight into FeIIIProtoporphyrin Binding to Cysteine-Based Heme-Regulatory Protein Motifs

ChemBioChem ◽  
2015 ◽  
Vol 16 (15) ◽  
pp. 2216-2224 ◽  
Author(s):  
Hans Henning Brewitz ◽  
Toni Kühl ◽  
Nishit Goradia ◽  
Kerstin Galler ◽  
Jürgen Popp ◽  
...  
Keyword(s):  
Regulatory Protein ◽  
Chemical Environment ◽  
Protein Motifs ◽  
Coordination Site ◽  
Structural Insight ◽  
Insight Into

scholarly journals KH-type splicing regulatory protein is a new component of chromatoid body

Reproduction ◽  
2017 ◽  
Vol 154 (6) ◽  
pp. 723-733 ◽  
Author(s):  
Huijuan Zhang ◽  
Guishuan Wang ◽  
Lin Liu ◽  
Xiaolin Liang ◽  
Yu Lin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Germ Cell ◽  
Knockout Mice ◽  
Binding Protein ◽  
Regulatory Protein ◽  
Somatic Cells ◽  
Chromatoid Body ◽  
Mechanistic Insight ◽  
Insight Into

The chromatoid body (CB) is a specific cloud-like structure in the cytoplasm of haploid spermatids. Recent findings indicate that CB is identified as a male germ cell-specific RNA storage and processing center, but its function has remained elusive for decades. In somatic cells, KH-type splicing regulatory protein (KSRP) is involved in regulating gene expression and maturation of select microRNAs (miRNAs). However, the function of KSRP in spermatogenesis remains unclear. In this study, we showed that KSRP partly localizes in CB, as a component of CB. KSRP interacts with proteins (mouse VASA homolog (MVH), polyadenylate-binding protein 1 (PABP1) and polyadenylate-binding protein 2 (PABP2)), mRNAs (Tnp2 and Odf1) and microRNAs (microRNA-182) in mouse CB. Moreover, KSRP may regulate the integrity of CB via DDX5-miRNA-182 pathway. In addition, we found abnormal expressions of CB component in testes of Ksrp-knockout mice and of patients with hypospermatogenesis. Thus, our results provide mechanistic insight into the role of KSRP in spermatogenesis.

scholarly journals A structural insight into the prokaryotic heat shock transcription regulatory protein s32: an implication of s32-DnaK interaction

2012 ◽  
Vol 8 (21) ◽  
pp. 1026-1029 ◽  
Author(s):  
Sourav Singha Roy ◽  
◽  
Monobesh Patra ◽  
Rakhi Dasgupta ◽  
Angshuman Bagchi
Keyword(s):  
Heat Shock ◽  
Regulatory Protein ◽  
Structural Insight ◽  
Insight Into

scholarly journals Structural insight into the role of the Ton complex in energy transduction

Nature ◽  
2016 ◽  
Vol 538 (7623) ◽  
pp. 60-65 ◽  
Author(s):  
Hervé Celia ◽  
Nicholas Noinaj ◽  
Stanislav D. Zakharov ◽  
Enrica Bordignon ◽  
Istvan Botos ◽  
...  
Keyword(s):  
Energy Transduction ◽  
Structural Insight ◽  
Insight Into

scholarly journals Structural insight into the role of Streptococcus parasanguinis Fap1 within oral biofilm formation

2012 ◽  
Vol 417 (1) ◽  
pp. 421-426 ◽  
Author(s):  
James A. Garnett ◽  
Peter J. Simpson ◽  
Jonathan Taylor ◽  
Stefi V. Benjamin ◽  
Camille Tagliaferri ◽  
...  
Keyword(s):  
Biofilm Formation ◽  
Oral Biofilm ◽  
Structural Insight ◽  
Insight Into ◽  
Streptococcus Parasanguinis

scholarly journals Structural Insight into the Role of the Ton Complex in Energy Transduction

2018 ◽  
Vol 114 (3) ◽  
pp. 206a
Author(s):  
Herve Celia ◽  
Nicholas Noinaj ◽  
Stanislov D. Zakarov ◽  
Enrica Bordignon ◽  
Istvan Botos ◽  
...  
Keyword(s):  
Energy Transduction ◽  
Structural Insight ◽  
Insight Into

Structural insight into inhibition of human Class II PI3K isoforms: homology modeling, binding site characterization, docking and molecular dynamics studies

RSC Advances ◽  
2016 ◽  
Vol 6 (113) ◽  
pp. 112455-112467 ◽  
Author(s):  
Vikash Kumar ◽  
Mohammad Imran Siddiqi
Keyword(s):  
Molecular Dynamics ◽  
Homology Modeling ◽  
Cell Survival ◽  
Therapeutic Intervention ◽  
Class Ii ◽  
Human Class ◽  
Lipid Kinases ◽  
Structural Insight ◽  
Insight Into

Phosphoinositide-3-kinases (PI3Ks) are family of lipid kinases, involved in cell survival, growth and proliferation. Role of Class II PI3Ks in cancer is emerging and gaining importance for the therapeutic intervention.

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