scholarly journals Molecular and Structural Insight into the Role of Key Residues of Thrombospondin-1 and Calreticulin in Thrombospondin-1−Calreticulin Binding

Biochemistry ◽  
2011 ◽  
Vol 50 (4) ◽  
pp. 566-573 ◽  
Author(s):  
Qi Yan ◽  
Joanne E. Murphy-Ullrich ◽  
Yuhua Song
Keyword(s):  
Thrombospondin 1 ◽  
Structural Insight ◽  
Key Residues ◽  
Insight Into

scholarly journals Structural Insight into the Binding of TGIF1 to SIN3A PAH2 Domain through a C-Terminal Amphipathic Helix

2021 ◽  
Vol 22 (23) ◽  
pp. 12631
Author(s):  
Xiaoling He ◽  
Yao Nie ◽  
Heng Zhou ◽  
Rui Hu ◽  
Ying Li ◽  
...  
Keyword(s):  
Transcriptional Repression ◽  
Structural Basis ◽  
Hydrophobic Core ◽  
Amphipathic Helix ◽  
Structural Insight ◽  
Function Relationship ◽  
And Function ◽  
Key Residues ◽  
Hydrophobic Cleft ◽  
Insight Into

TGIF1 is a transcriptional repressor playing crucial roles in human development and function and is associated with holoprosencephaly and various cancers. TGIF1-directed transcriptional repression of specific genes depends on the recruitment of corepressor SIN3A. However, to date, the exact region of TGIF1 binding to SIN3A was not clear, and the structural basis for the binding was unknown. Here, we demonstrate that TGIF1 utilizes a C-terminal domain (termed as SIN3A-interacting domain, SID) to bind with SIN3A PAH2. The TGIF1 SID adopts a disordered structure at the apo state but forms an amphipathic helix binding into the hydrophobic cleft of SIN3A PAH2 through the nonpolar side at the holo state. Residues F379, L382 and V383 of TGIF1 buried in the hydrophobic core of the complex are critical for the binding. Moreover, homodimerization of TGIF1 through the SID and key residues of F379, L382 and V383 was evidenced, which suggests a dual role of TGIF1 SID and a correlation between dimerization and SIN3A-PAH2 binding. This study provides a structural insight into the binding of TGIF1 with SIN3A, improves the knowledge of the structure–function relationship of TGIF1 and its homologs and will help in recognizing an undiscovered SIN3A-PAH2 binder and developing a peptide inhibitor for cancer treatment.

scholarly journals Structural insight into the role of the Ton complex in energy transduction

Nature ◽  
2016 ◽  
Vol 538 (7623) ◽  
pp. 60-65 ◽  
Author(s):  
Hervé Celia ◽  
Nicholas Noinaj ◽  
Stanislav D. Zakharov ◽  
Enrica Bordignon ◽  
Istvan Botos ◽  
...  
Keyword(s):  
Energy Transduction ◽  
Structural Insight ◽  
Insight Into

scholarly journals Structural insight into the role of Streptococcus parasanguinis Fap1 within oral biofilm formation

2012 ◽  
Vol 417 (1) ◽  
pp. 421-426 ◽  
Author(s):  
James A. Garnett ◽  
Peter J. Simpson ◽  
Jonathan Taylor ◽  
Stefi V. Benjamin ◽  
Camille Tagliaferri ◽  
...  
Keyword(s):  
Biofilm Formation ◽  
Oral Biofilm ◽  
Structural Insight ◽  
Insight Into ◽  
Streptococcus Parasanguinis

scholarly journals Structural Insight into the Role of the Ton Complex in Energy Transduction

2018 ◽  
Vol 114 (3) ◽  
pp. 206a
Author(s):  
Herve Celia ◽  
Nicholas Noinaj ◽  
Stanislov D. Zakarov ◽  
Enrica Bordignon ◽  
Istvan Botos ◽  
...  
Keyword(s):  
Energy Transduction ◽  
Structural Insight ◽  
Insight Into

Structural insight into inhibition of human Class II PI3K isoforms: homology modeling, binding site characterization, docking and molecular dynamics studies

RSC Advances ◽  
2016 ◽  
Vol 6 (113) ◽  
pp. 112455-112467 ◽  
Author(s):  
Vikash Kumar ◽  
Mohammad Imran Siddiqi
Keyword(s):  
Molecular Dynamics ◽  
Homology Modeling ◽  
Cell Survival ◽  
Therapeutic Intervention ◽  
Class Ii ◽  
Human Class ◽  
Lipid Kinases ◽  
Structural Insight ◽  
Insight Into

Phosphoinositide-3-kinases (PI3Ks) are family of lipid kinases, involved in cell survival, growth and proliferation. Role of Class II PI3Ks in cancer is emerging and gaining importance for the therapeutic intervention.

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