Kanamycin A-Derived Cationic Lipids as Vectors for Gene Transfection

ChemBioChem ◽  
2005 ◽  
Vol 6 (6) ◽  
pp. 1023-1033 ◽  
Author(s):  
Matthieu Sainlos ◽  
Michelle Hauchecorne ◽  
Noufissa Oudrhiri ◽  
Samia Zertal-Zidani ◽  
Abderrahim Aissaoui ◽  
...  
Keyword(s):  
Gene Transfection ◽  
Cationic Lipids

Synthesis and gene transfection activity of cyclen-based cationic lipids with asymmetric acyl-cholesteryl hydrophobic tails

2014 ◽  
Vol 12 (21) ◽  
pp. 3484-3492 ◽  
Author(s):  
Bao-Quan Liu ◽  
Wen-Jing Yi ◽  
Ji Zhang ◽  
Qiang Liu ◽  
Yan-Hong Liu ◽  
...  
Keyword(s):  
Gene Transfection ◽  
Cationic Lipids ◽  
Viral Gene ◽  
Gene Vectors

Novel cyclen-based cationic lipids with asymmetric acyl-cholesteryl hydrophobic tails were synthesized and applied as non-viral gene vectors.

scholarly journals Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery

2017 ◽  
Vol 53 (59) ◽  
pp. 8328-8331 ◽  
Author(s):  
Jamie C. Gaitor ◽  
Lauren M. Paul ◽  
Melissa M. Reardon ◽  
Taha Hmissa ◽  
Samuel Minkowicz ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Gene Delivery ◽  
Click Chemistry ◽  
Gene Transfection ◽  
Cationic Lipids ◽  
Efficient Gene

Novel lipidic ionic liquids with imidazolium headgroups (red), thioether linkers (black), and two hydrophobic tails (blue) as efficient gene transfection vectors, synthesized via thiol–yne click chemistry.

α‐Tocopherol‐Conjugated, Open Chain Sugar‐Mimicking Cationic Lipids: Design, Synthesis and In–Vitro Gene Transfection Properties

2021 ◽  
Vol 6 (46) ◽  
pp. 13025-13033
Author(s):  
Venkatesh Ravula ◽  
Venkanna Muripiti ◽  
Shireesha Manthurthi ◽  
Srilakshmi V. Patri
Keyword(s):  
Gene Transfection ◽  
Cationic Lipids ◽  
Open Chain ◽  
Design Synthesis

Dramatic influence of the hydroxy functionality of azasugar moiety in the head group region of tocopherol-based cationic lipids on in vitro gene transfection efficacies

2021 ◽  
Author(s):  
Venkanna Muripiti ◽  
Brijesh Lohchania ◽  
Venkatesh Ravula ◽  
Shireesha Manturthi ◽  
Srujan Marepally ◽  
...  
Keyword(s):  
Gene Transfection ◽  
Cationic Lipids ◽  
Head Group ◽  
Nonviral Vectors

Cationic lipids have been effectively used as nonviral vectors for the delivery of polynucleic acids into the cytosol.

Cationic lipids derived from glycine betaine promote efficient and non-toxic gene transfection in cultured hepatocytes

2002 ◽  
Vol 4 (4) ◽  
pp. 415-427 ◽  
Author(s):  
David Gilot ◽  
Marie-Laure Miramon ◽  
Thierry Benvegnu ◽  
Vincent Ferrieres ◽  
Olivier Loreal ◽  
...  
Keyword(s):  
Glycine Betaine ◽  
Gene Transfection ◽  
Cationic Lipids ◽  
Cultured Hepatocytes ◽  
Toxic Gene

Cationic niosomes composed of spermine-based cationic lipids mediate high gene transfection efficiency

2012 ◽  
Vol 20 (9) ◽  
pp. 783-792 ◽  
Author(s):  
Orapan Paecharoenchai ◽  
Nattisa Niyomtham ◽  
Tanasait Ngawhirunpat ◽  
Theerasak Rojanarata ◽  
Boon-ek Yingyongnarongkul ◽  
...  
Keyword(s):  
Transfection Efficiency ◽  
Gene Transfection ◽  
Cationic Lipids ◽  
High Gene ◽  
Cationic Niosomes

scholarly journals Efficiency and cytotoxicity analysis of cationic lipids-mediated gene transfection into AGS gastric cancer cells

2017 ◽  
Vol 46 (5) ◽  
pp. 1001-1008 ◽  
Author(s):  
Nasrin Gharaati-Far ◽  
Mohammad Reza Tohidkia ◽  
Alireza Dehnad ◽  
Yadollah Omidi
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Gene Transfection ◽  
Cationic Lipids ◽  
Gastric Cancer Cells

Effect of Acyl Chain Length of Spermine Derivatives on Transfection Efficiency

2012 ◽  
Vol 506 ◽  
pp. 445-448 ◽  
Author(s):  
Orapan Paecharoenchai ◽  
Nattisa Niyomtham ◽  
A. Apirakaramwong ◽  
B. Yingyongnarongkul ◽  
Praneet Opanasopit
Keyword(s):  
Transfection Efficiency ◽  
Gene Transfection ◽  
Acyl Chain ◽  
Weight Ratio ◽  
Cationic Liposomes ◽  
Cationic Lipids ◽  
Head Group ◽  
Chemical Structures ◽  
Cytotoxicity Studies ◽  
Cell Line Hela

In this study, cationic liposomes prepared from egg phosphatidylcholine (PC) and novel spermine-based cationic lipids at a molar ratio of 5:1 were formulated. The chemical structures of these cationic lipids consisted of spermine head group and four hydrocarbon tails with differences in acyl chain (C14, C16 and C18). The effects of acyl chain and weight ratio of liposomes to DNA on transfection efficiency and cytotoxicity were investigated on a human cervical carcinoma cell line (HeLa cells) using the pDNA encoding green fluorescent protein (pEGFP-C2). The results from agarose gel electrophoresis illustrated that all cationic liposomes were able to condense with pDNA. The transfection efficiency of these cationic liposomes was in the following order: C18 (3,497±120 cells/cm2) > C14 (809±52 cells/cm2) > C16 (91±5 cells/cm2). The highest transfection efficiency was observed in the formulation of cationic liposomes with C18 tail at weight ratio of 15. In cytotoxicity studies, all formulations showed low cytotoxicity. In conclusion, these cationic liposomes containing novel cationic lipids (C18), showed promising potential as a gene carrier by efficient DNA condensation and mediated higher level of gene transfection.

Sign in / Sign up

Export Citation Format

Share Document