LINC‐PINT suppresses tumour cell proliferation, migration and invasion through targeting miR ‐374a‐5p in ovarian cancer

2020 ◽  
Vol 38 (8) ◽  
pp. 1089-1099
Author(s):  
Ting Hao ◽  
Shu Huang ◽  
Fangzheng Han
Keyword(s):  
Ovarian Cancer ◽  
Cell Proliferation ◽  
Tumour Cell ◽  
Migration And Invasion ◽  
Tumour Cell Proliferation

Heated and humidified CO2pneumoperitoneum inhibits tumour cell proliferation, migration and invasion in colon cancer

2014 ◽  
Vol 30 (3) ◽  
pp. 201-209 ◽  
Author(s):  
Wei Cai ◽  
Feng Dong ◽  
Zhengting Wang ◽  
Xiaohua Yang ◽  
Minhua Zheng ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Tumour Cell ◽  
Migration And Invasion ◽  
Tumour Cell Proliferation

scholarly journals MIP-2A Is a Novel Target of an Anilinoquinazoline Derivative for Inhibition of Tumour Cell Proliferation

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e76774 ◽  
Author(s):  
Mayuko Tokunaga ◽  
Hirokazu Shiheido ◽  
Noriko Tabata ◽  
Yuko Sakuma-Yonemura ◽  
Hideaki Takashima ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumour Cell ◽  
Tumour Cell Proliferation ◽  
Novel Target

scholarly journals In vivo tumour-cell proliferation after adriamycin treatment

1982 ◽  
Vol 45 (3) ◽  
pp. 429-437 ◽  
Author(s):  
R Rowley ◽  
H A Hopkins ◽  
W B Looney
Keyword(s):  
Cell Proliferation ◽  
Tumour Cell ◽  
Tumour Cell Proliferation

LncRNA SNHG14 Promotes Progression of Ovarian Cancer by Regulating miR-206 Expression

2021 ◽  
Vol 7 (5) ◽  
pp. 3997-4004
Author(s):  
Zhibo Zou ◽  
Lin Peng
Keyword(s):  
Ovarian Cancer ◽  
Flow Cytometry ◽  
Cell Proliferation ◽  
Tumor Growth ◽  
Cancer Progression ◽  
Nude Mice ◽  
Luciferase Reporter ◽  
Migration And Invasion ◽  
Qrt Pcr ◽  
Research Objects

Objective: This study aimed to probe into the effect of LncRNA SNHG14 on ovarian cancer progression by regulating miR-206.Methods: Fifty-seven ovarian cancer (OC) patients who were treated in our hospital from December 2017 to December 2019 were collected as the research objects. During the operation, OC tissues and paracancerous tissues of patients were collected, and the effect of SNHG14 on OC tumor growth in nude mice was detected, and SNHG14 inhibitor was transfected into OC cells. The relative expression of SNHG14 in tissues and cells was detected by qRT-PCR, cell proliferation was testedvia CCK8, migration and invasion were detected through Transwell, apoptosis was assessedvia flow cytometry, and the targeted relationship between SNHG14 and miR-206 was detected by dual luciferase reporter gene.Results: SNHG14 is highly expressed in OC tissues, cells and nude mice. Down-regulating it can inhibit the biological ability of OC cells and inhibit the growth of nude mice tumors. It can directly target miR-206 to regulate CCND1 expression and promote OC progression.Conclusion: LncRNA SNHG14 can act as miR-206 sponge to regulate CCND1 expression downstream of miR-206 and promote OC progression.

scholarly journals Overexpression of KIF2A is Suppressed by miR-206 and Associated with Poor Prognosis in Ovarian Cancer

2018 ◽  
Vol 50 (3) ◽  
pp. 810-822 ◽  
Author(s):  
Nan Sheng ◽  
Yun-Zhao Xu ◽  
Qing-Hua Xi ◽  
Hai-Yan Jiang ◽  
Chen-Yi Wang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Poor Prognosis ◽  
Ovarian Cancer Cell ◽  
Expression Profiles ◽  
Annexin V ◽  
Prognostic Indicator ◽  
Luciferase Reporter ◽  
Migration And Invasion

Background/Aims: This study aimed to investigate the expression and prognostic value of kinesin family member 2A (KIF2A) and the suppression effects of microRNA-206 (miR-206) on KIF2A in ovarian cancer. Methods: Ovarian cancer tissues from patients and ovarian cancer cell lines (A2780 and SKOV3) were used in this study. miR-206 mimics and control were transiently transfected into cells. RT-qPCR was performed to detect KIF2A mRNA and miR-206 expression levels, Western blot was performed to detect KIF2A protein levels, Dual-Luciferase Reporter Assay was used to examine the inhibition effects of miR-206 on KIF2A mRNA, immunohistochemical staining was used to examine the expression of KIF2A in tissue sections. CCK-8, transwell and Annexin-V-FITC/Propidium Iodide staining with flow cytometry were used to detect the cell proliferation, migration/invasion, and apoptosis respectively. Results: Our study explored the expression profiles of KIF2A and miR-206 in the patients with ovarian cancer. We found that overexpression of KIF2A was associated with a poor prognosis in ovarian cancer. We also found that KIF2A mRNA contains two target sites for miR-206 binding and confirmed that miR-206 directly suppresses KIF2A; inhibits ovarian cancer cell proliferation, migration, and invasion; and induces apoptosis. Conclusion: The results suggest KIF2A could serve a valuable prognostic indicator in ovarian cancer and provide a rationale for treatment of ovarian cancer by targeting KIF2A via miR-206.

Tumour cell proliferation is abolished by inhibitors of and exchange

1993 ◽  
Vol 29 (1) ◽  
pp. 132-137 ◽  
Author(s):  
Branka Horvat ◽  
Shahram Taheri ◽  
Aida Salihagić
Keyword(s):  
Cell Proliferation ◽  
Tumour Cell ◽  
Tumour Cell Proliferation
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