scholarly journals In vivo tumour-cell proliferation after adriamycin treatment

1982 ◽  
Vol 45 (3) ◽  
pp. 429-437 ◽  
Author(s):  
R Rowley ◽  
H A Hopkins ◽  
W B Looney
Keyword(s):  
Cell Proliferation ◽  
Tumour Cell ◽  
Tumour Cell Proliferation

scholarly journals Inhibitory effect of yoghurt and soya yoghurt containing bifidobacteria on the proliferation of Ehrlich ascites tumour cells in vitro and in vivo in a mouse tumour model

2004 ◽  
Vol 92 (1) ◽  
pp. 81-86 ◽  
Author(s):  
I. A. Abd El-Gawad ◽  
E. M. El-Sayed ◽  
S. A. Hafez ◽  
H. M. El-Zeini ◽  
F. A. Saleh
Keyword(s):  
Cell Proliferation ◽  
Tumour Cell ◽  
Tumour Cells ◽  
Soya Milk ◽  
Ascites Tumour ◽  
Ehrlich Ascites ◽  
Ehrlich Ascites Tumour ◽  
Tumour Cell Proliferation

The effect of yoghurt and soya yoghurt containing Bifidobacterium lactis Bb-12 or B. longum Bb-46 on Ehrlich ascites tumour cell proliferation was investigated in vitro and in vivo. Tumour cells were incubated with B. lactis Bb-12 or B. longum Bb-46 cultivated in de Mann Rogosa Sharpe (MRS) broth medium, or with their centrifuged supernatant fractions or sediments, for 2 h at 37°C. Treatment resulted in the inhibition of tumour cell proliferation by 85·42 (sd 0·78) and 85·10 (sd 1·28) % by intact micro-organisms, 77·61 (sd 0·29) and 71·43 (sd 1·75) % by their supernatant fractions, but only 4·00 (sd 0·19) and 9·09 (sd 1·24) % by the two sedimented bacteria, respectively. The incubation of tumour cells with yoghurt and soya yoghurt containing Bb-12 for 2 h resulted in 83·01 (sd 0·11) and 88·23 (sd 0·06) % inhibition, respectively, while it was 83·82 (sd 0·24) and 86·36 (sd 0·06) %, respectively for the same products containing Bb-46. Corresponding values for plain yoghurt and soya milk (without bifidobacteria) were 32·81 (sd 0·14) and 5·55 (sd 0·12) %, respectively. The differences between yoghurt or soya yoghurt containing Bb-12 or Bb-46 and plain yoghurt, soya milk or control treatments were statistically significant (n 3; P>0·05). Female Swiss albino mice were injected intraperitoneally with the same tumour cells. The lifespan of mice fed diets supplemented with yoghurt or soya yoghurt containing Bb-12 or Bb-46 was prolonged by 16, 23, 34 and 39%, respectively compared with that of the positive control group (n 6; P>0·05). The lifespan of groups fed plain yoghurt or soya milk was prolonged by 15 and 8%, respectively. Prolongation of lifespan was positively correlated with faeces bifidobacterial count in the groups fed yoghurt or soya yoghurt containing bifidobacteria (r 0·917; P>0·05).

scholarly journals CHCHD4 regulates a proliferation-EMT switch in tumour cells, through respiratory complex I mediated metabolism

2019 ◽  
Author(s):  
Luke W. Thomas ◽  
Cinzia Esposito ◽  
Jenna M. Stephen ◽  
Ana S. H. Costa ◽  
Christian Frezza ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Respiratory Chain ◽  
Tumour Cell ◽  
Complex I ◽  
Coiled Coil ◽  
Gene Signature ◽  
Tumour Cells ◽  
Mitochondrial Metabolism ◽  
Tumour Cell Proliferation

ABSTRACTBACKGROUNDMitochondrial metabolism involves oxidative phosphorylation (OXPHOS) via the respiratory chain and is required for the maintenance of tumour cell proliferation and regulation of epithelial–mesenchymal transition (EMT)-related phenotypes through mechanisms that are not fully understood. The essential mitochondrial import protein coiled-coil helix coiled-coil helix domain-containing protein 4 (CHCHD4) controls respiratory chain complex activity and oxygen consumption, and regulates the growth of tumours in vivo. In this study we interrogate the role of CHCHD4-regulated respiratory chain activity and metabolism in tumour cell proliferation and EMT-related phenotypes.RESULTSWe show that CHCHD4 is essential for the proliferation of tumour cells irrespective of their aetiology. In human tumours, elevated CHCHD4 expression is correlated with a mitochondrial OXPHOS gene signature and with a proliferative gene signature associated with the mTORC1 signalling pathway. Elevated CHCHD4 increases tumour cell proliferation, in a manner that is dependent on complex I (CI) activity, glutamine consumption and mTORC1 activation. CHCHD4 expression is inversely correlated with EMT gene expression both in vitro and in vivo. Finally, we show CHCHD4 regulates the intracellular distribution of the EMT marker vimentin, in a CI-mediated manner.CONCLUSIONSCHCHD4 regulates tumour cell proliferation and metastatic (EMT-related) phenotypes through its control of CI-mediated mitochondrial metabolism.

scholarly journals MIP-2A Is a Novel Target of an Anilinoquinazoline Derivative for Inhibition of Tumour Cell Proliferation

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e76774 ◽  
Author(s):  
Mayuko Tokunaga ◽  
Hirokazu Shiheido ◽  
Noriko Tabata ◽  
Yuko Sakuma-Yonemura ◽  
Hideaki Takashima ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumour Cell ◽  
Tumour Cell Proliferation ◽  
Novel Target

Tumour cell proliferation is abolished by inhibitors of and exchange

1993 ◽  
Vol 29 (1) ◽  
pp. 132-137 ◽  
Author(s):  
Branka Horvat ◽  
Shahram Taheri ◽  
Aida Salihagić
Keyword(s):  
Cell Proliferation ◽  
Tumour Cell ◽  
Tumour Cell Proliferation

scholarly journals Immunohistochemical detection of tumour cell proliferation and intratumoural microvessel density in canine malignant mammary tumours

2015 ◽  
Vol 59 (2) ◽  
pp. 255-261
Author(s):  
Gulbin Sennazli ◽  
Funda Yildirim ◽  
Seckin Serdar Arun ◽  
Aydin Gurel ◽  
Kivilcim Sonmez
Keyword(s):  
Cell Proliferation ◽  
Tumour Cell ◽  
Cellular Proliferation ◽  
Histological Grade ◽  
Mammary Tissue ◽  
Biological Behaviour ◽  
Ki 67 ◽  
Tissue Samples ◽  
Mammary Tumours ◽  
Tumour Cell Proliferation

Abstract The objective of this study was to investigate the correlation between different histological types and grades of canine malignant mammary tumours, tumour cell proliferation and their angiogenic activity using immunohistochemical markers. Mammary tissue samples from 47 bitches with mammary cancer were evaluated. The expression of cellular proliferation marker Ki-67 and endothelial marker Von Willebrand’s factor (vWF) were immunohistochemically demonstrated. The tumours with the highest Ki-67 and vWF expressions were found to share similar histomorphological features. Simple solid carcinoma had the highest levels of Ki-67, vWF, and higher histological grade while complex carcinomas, osteosarcomas, and carcinosarcomas had the lowest ones. The differences between the expressions of Ki-67 and vWF in different tumour types were considered to be of great importance in determination of biological behaviour and prognosis of these tumours. This study is one of the few studies that evaluate these differences among the subtypes of malignant canine mammary tumours

Sign in / Sign up

Export Citation Format

Share Document