Expression of NF-κB and downstream antioxidant genes in skeletal muscle of hibernating ground squirrels,Spermophilus tridecemlineatus

2011 ◽  
Vol 30 (2) ◽  
pp. 166-174 ◽  
Author(s):  
Marcus E. Allan ◽  
Kenneth B. Storey
Keyword(s):  
Skeletal Muscle ◽  
Ground Squirrels ◽  
Spermophilus Tridecemlineatus ◽  
Antioxidant Genes

scholarly journals Myostatin levels in skeletal muscle of hibernating ground squirrels

2011 ◽  
Vol 214 (15) ◽  
pp. 2522-2527 ◽  
Author(s):  
N. E. Brooks ◽  
K. H. Myburgh ◽  
K. B. Storey
Keyword(s):  
Skeletal Muscle ◽  
Ground Squirrels

scholarly journals Nitrogen recycling buffers against ammonia toxicity from skeletal muscle breakdown in hibernating arctic ground squirrels

2020 ◽  
Vol 2 (12) ◽  
pp. 1459-1471
Author(s):  
Sarah A. Rice ◽  
Gabriella A. M. Ten Have ◽  
Julie A. Reisz ◽  
Sarah Gehrke ◽  
Davide Stefanoni ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Ground Squirrels ◽  
Ammonia Toxicity ◽  
Nitrogen Recycling ◽  
Muscle Breakdown ◽  
Arctic Ground Squirrels

Dietary supplementation with MicroActive Coenzyme Q10 increases expression of antioxidant genes in Thoroughbred skeletal muscle

2018 ◽  
Vol 1859 ◽  
pp. e45
Author(s):  
Caitriona E. Curley ◽  
Mary F. Rooney ◽  
Michael E. Griffin ◽  
Lisa M. Katz ◽  
Richard K. Porter ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Coenzyme Q10 ◽  
Dietary Supplementation ◽  
Antioxidant Genes

scholarly journals Circulation and metabolic rates in a natural hibernator: an integrative physiological model

2010 ◽  
Vol 299 (6) ◽  
pp. R1478-R1488 ◽  
Author(s):  
Marshall Hampton ◽  
Bethany T. Nelson ◽  
Matthew T. Andrews
Keyword(s):  
Body Temperature ◽  
Metabolic Rate ◽  
Core Body Temperature ◽  
Circulatory System ◽  
Physiological Model ◽  
Ground Squirrels ◽  
Metabolic Rates ◽  
Spermophilus Tridecemlineatus ◽  
Brown Adipose ◽  
Core Body

Small hibernating mammals show regular oscillations in their heart rate and body temperature throughout the winter. Long periods of torpor are abruptly interrupted by arousals with heart rates that rapidly increase from 5 beats/min to over 400 beats/min and body temperatures that increase by ∼30°C only to drop back into the hypothermic torpid state within hours. Surgically implanted transmitters were used to obtain high-resolution electrocardiogram and body temperature data from hibernating thirteen-lined ground squirrels ( Spermophilus tridecemlineatus ). These data were used to construct a model of the circulatory system to gain greater understanding of these rapid and extreme changes in physiology. Our model provides estimates of metabolic rates during the torpor-arousal cycles in different model compartments that would be difficult to measure directly. In the compartment that models the more metabolically active tissues and organs (heart, brain, liver, and brown adipose tissue) the peak metabolic rate occurs at a core body temperature of 19°C approximately midway through an arousal. The peak metabolic rate of the active tissues is nine times the normothermic rate after the arousal is complete. For the overall metabolic rate in all tissues, the peak-to-resting ratio is five. This value is high for a rodent, which provides evidence for the hypothesis that the arousal from torpor is limited by the capabilities of the cardiovascular system.

Regulation of UCP1 and UCP3 in arctic ground squirrels and relation with mitochondrial proton leak

2006 ◽  
Vol 101 (1) ◽  
pp. 339-347 ◽  
Author(s):  
Jamie L. Barger ◽  
Brian M. Barnes ◽  
Bert B. Boyer
Keyword(s):  
Skeletal Muscle ◽  
Ground Squirrels ◽  
Proton Leak ◽  
Mrna Levels ◽  
Nonesterified Fatty Acids ◽  
Protein Levels ◽  
Bat Mitochondria ◽  
Brown Adipose ◽  
Arctic Ground Squirrels ◽  
Ucp3 Expression

Uncoupling protein (UCP) 1 (UCP1) catalyzes a proton leak in brown adipose tissue (BAT) mitochondria that results in nonshivering thermogenesis (NST), but the extent to which UCP homologs mediate NST in other tissues is controversial. To clarify the role of UCP3 in mediating NST in a hibernating species, we measured Ucp3 expression in skeletal muscle of arctic ground squirrels in one of three activity states (not hibernating, not hibernating and fasted for 48 h, or hibernating) and housed at 5°C or −10°C. We then compared Ucp3 mRNA levels in skeletal muscle with Ucp1 mRNA and UCP1 protein levels in BAT in the same animals. Ucp1 mRNA and UCP1 protein levels were increased on cold exposure and decreased with fasting, with the highest UCP1 levels in thermogenic hibernators. In contrast, Ucp3 mRNA levels were not affected by temperature but were increased 10-fold during fasting and >3-fold during hibernation. UCP3 protein levels were increased nearly fivefold in skeletal muscle mitochondria isolated from fasted squirrels compared with nonhibernators, but proton leak kinetics in the presence of BSA were unchanged. Proton leak in BAT mitochondria also did not differ between fed and fasted animals but did show classical inhibition by the purine nucleotide GDP. Levels of nonesterified fatty acids were highest during hibernation, and tissue temperatures during hibernation were related to Ucp1, but not Ucp3, expression. Taken together, these results do not support a role for UCP3 as a physiologically relevant mediator of NST in muscle.

Expression of Nrf2 and its downstream gene targets in hibernating 13-lined ground squirrels, Spermophilus tridecemlineatus

2008 ◽  
Vol 312 (1-2) ◽  
pp. 121-129 ◽  
Author(s):  
Pier Jr Morin ◽  
Zhouli Ni ◽  
David C. McMullen ◽  
Kenneth B. Storey
Keyword(s):  
Ground Squirrels ◽  
Spermophilus Tridecemlineatus
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