Age-related effects of DHEA on peripheral markers of oxidative stress

2010 ◽  
Vol 28 (1) ◽  
pp. 52-57 ◽  
Author(s):  
Maria Helena Vianna Metello Jacob ◽  
Daiane da R. Janner ◽  
Matheus Parmegiani Jahn ◽  
Luiz Carlos Kucharski ◽  
Adriane Belló-Klein ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Age Related ◽  
Markers Of Oxidative Stress ◽  
Peripheral Markers

Peripheral markers of oxidative stress in Parkinson’s disease. the role of L-DOPA

1999 ◽  
Vol 27 (3-4) ◽  
pp. 428-437 ◽  
Author(s):  
E Martignoni ◽  
F Blandini ◽  
L Godi ◽  
S Desideri ◽  
C Pacchetti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Markers Of Oxidative Stress ◽  
Peripheral Markers

scholarly journals Dietary Supplementation with Beta-Cryptoxanthin (BCX) Protects Against Light-Induced Retinal Damage

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 126-126
Author(s):  
Deshanie Rai ◽  
Kazim Sahin ◽  
Kazim Sahin ◽  
Emre Sahin ◽  
Mehmet Tuzcu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Angiogenic Factor ◽  
Retinal Damage ◽  
Waste Products ◽  
Health Technologies ◽  
Retinal Tissue ◽  
Age Related ◽  
Markers Of Oxidative Stress

Abstract Objectives The retinal pigment epithelium (RPE) regulates the transport of nutrients and waste products to and from the retina and protects against light and oxidative stress. Structural or physiological dysfunction of RPE leads to retinal conditions such as age-related eye disease (ARED). It is well-established that artificial and natural light is an important factor in the progression of ARED as it can induce oxidative damage and photochemical lesions. Recently, the use of LED in general lighting has raised concerns regarding the effects of this light source on the RPE. The goal was to investigate whether beta-cryptoxanthin, an efficient pro-vitamin A carotenoid can exert protective effects against LED-induced RPE cell damage. Methods Rats were fed with BCX for 4 weeks at a dose of 2 and 4 mg/kg body weight followed by retinal damage by exposing the eye to bright LED light for 48 hrs. Commercially available white LED sources, which are widely used in rat housing studies was used to induce retinal damage. Animals were sacrificed at the end of the study and retinal tissue and blood samples were collected and evaluated for retinal damage and markers of oxidative stress. Results BCX supplementation significantly reduced retinal damage as demonstrated by histopathology measurements including total retinal thickness, outer nuclear layer thickness, and swelling. Similarly, markers of oxidative stress including serum and retinal tissue levels of malondialdehyde, superoxide dismutase, glutathione peroxidase, and catalase were beneficially modulated by BCX supplementation. In parallel, BCX supplementation reduced inflammatory markers (IL-1β, IL-6, NF-κB), angiogenic factor VEGF, apoptotic proteins (Caspase-3, GAP43, GFAP, NCAM, HO-1) and mitochondrial stress markers (ATF4, ATF6, Grp78, Grp97) in retinal tissue. Conclusions Our study supports that oral supplementation of BCX dose-dependently exerts a protective effect against retinal damage induced by high-intensity light in a rat model by reducing oxidative stress, inflammation, angigogenesis and protection against mitochondrial DNA damage. BCX dietary intakes and supplementation throughout all stages of life can help protect against ARED that may start early in life. Funding Sources OmniActive Health Technologies.

scholarly journals Obesity and Age-Related Changes in Markers of Oxidative Stress and Inflammation Across Four Generations

Obesity ◽  
2016 ◽  
Vol 24 (6) ◽  
pp. 1389-1396 ◽  
Author(s):  
Gerben Hulsegge ◽  
Gerrie-Cor M. Herber-Gast ◽  
Annemieke M.W. Spijkerman ◽  
H. Susan ◽  
J. Picavet ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Age Related ◽  
Markers Of Oxidative Stress ◽  
Age Related Changes

scholarly journals Peripheral markers of oxidative stress in chronic mercuric chloride intoxication

2006 ◽  
Vol 39 (6) ◽  
pp. 767-772 ◽  
Author(s):  
L.L.P. Gutierrez ◽  
N.G. Mazzotti ◽  
A.S.R. Araújo ◽  
R.B. Klipel ◽  
T.R.G. Fernandes ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mercuric Chloride ◽  
Markers Of Oxidative Stress ◽  
Peripheral Markers

scholarly journals Markers of Oxidative Stress in Erythrocytes and Plasma During Aging in Humans

2010 ◽  
Vol 3 (1) ◽  
pp. 2-12 ◽  
Author(s):  
Kanti Bhooshan Pandey ◽  
Syed Ibrahim Rizvi
Keyword(s):  
Oxidative Stress ◽  
Aging Process ◽  
Biological Process ◽  
Related Phenomenon ◽  
Free Radical Theory ◽  
Radical Theory ◽  
Age Related ◽  
General Decline ◽  
Markers Of Oxidative Stress ◽  
Probability Of Death

Aging is an inevitable universal biological process, which can be characterized by a general decline in physiological function with the accumulation of diverse adverse changes and increased probability of death. Among several theories, oxidative stress/free radical theory offers the best mechanistic elucidation of the aging process and other age-related phenomenon. In the present paper, we discuss the aging process and have focused on the importance of some reliable markers of oxidative stress which may be used as biomarkers of the aging process.

Peripheral markers of oxidative stress and antioxidative defense in euthymia of bipolar disorder—Gender and obesity effects

2015 ◽  
Vol 172 ◽  
pp. 367-374 ◽  
Author(s):  
S.A. Bengesser ◽  
N. Lackner ◽  
A. Birner ◽  
F.T. Fellendorf ◽  
M. Platzer ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bipolar Disorder ◽  
Antioxidative Defense ◽  
Markers Of Oxidative Stress ◽  
Peripheral Markers

The effects of tirofiban on peripheral markers of oxidative stress and endothelial dysfunction in patients with acute coronary syndromes

2007 ◽  
Vol 119 (2) ◽  
pp. 167-174 ◽  
Author(s):  
Efstathios K. Iliodromitis ◽  
Ioanna Andreadou ◽  
Sophia Markantonis-Kyroudis ◽  
Kalliopi Mademli ◽  
Stamatis Kyrzopoulos ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Acute Coronary Syndromes ◽  
Markers Of Oxidative Stress ◽  
Coronary Syndromes ◽  
Peripheral Markers

scholarly journals Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Dominik Szwajgier ◽  
Ewa Baranowska-Wójcik ◽  
Joanna Grzelczyk ◽  
Wioletta Żukiewicz-Sobczak
Keyword(s):  
Oxidative Stress ◽  
Down Syndrome ◽  
Matched Control ◽  
Dietary Supplementation ◽  
Dose Effect ◽  
Control Groups ◽  
Markers Of Oxidative Stress ◽  
Nutritional Studies ◽  
Peripheral Markers ◽  
Healthy Persons

Oxidative stress plays an important role in Down syndrome (DS) pathology since the gene dose effect leads to abnormal levels of certain enzymes and metabolites. In this review, we focused on relatively easy-to-obtain, peripheral markers of oxidative stress and inflammation, in order to compare the levels of these markers in DS patients and chromosomally healthy persons. Studies taking into account age- and sex-matched control groups were of particular interest in this context. We analyzed the factors that influence the levels of said markers in both groups (i.e., the usefulness of the markers), including the age of DS patients, occurrence of regular trisomy 21 or mosaicism, physical activity of patients, and the onset of Alzheimer’s disease in DS. This paper was conceived as a handbook—to help for selecting suitable, easy-to-obtain markers for monitoring of the health status of DS patients (e.g., in nutritional studies and during dietary supplementation).

scholarly journals Peripheral biomarkers of oxidative stress in aging and Alzheimer's disease

2008 ◽  
Vol 2 (1) ◽  
pp. 2-8 ◽  
Author(s):  
Tania Marcourakis ◽  
Rosana Camarini ◽  
Elisa Mitiko Kawamoto ◽  
Leandro Rodrigues Scorsi ◽  
Cristoforo Scavone
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Disorders ◽  
Stress Markers ◽  
Markers Of Oxidative Stress ◽  
The Central Nervous System ◽  
Peripheral Markers ◽  
Lateral Sclerosis ◽  
Biomarkers Of Oxidative Stress

Abstract Aging is associated with a greatly increased incidence of a number of neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). These conditions are associated with chronic inflammation, which generates oxygen reactive species, ultimately responsible for a process known as oxidative stress. It is well established that this process is the culprit of neurodegeneration, and there are also mounting evidences that it is not restricted to the central nervous system. Indeed, several studies, including some by our group, have demonstrated that increased peripheral oxidative stress markers are associated to aging and, more specifically, to AD. Therefore, it is very instigating to regard aging and AD as systemic conditions that might be determined by studying peripheral markers of oxidative stress.

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