Hydroxycinnamic acid amide dimers from goji berry and their potential anti‐AD activity

Author(s):  
Yin Qiang ◽  
Tian Chai ◽  
Wen-Han Zhang ◽  
Hui Jiao
2019 ◽  
Vol 100 (6) ◽  
pp. 591-605 ◽  
Author(s):  
Shailesh Karre ◽  
Arun Kumar ◽  
Kalenahalli Yogendra ◽  
Udaykumar Kage ◽  
Ajjamada Kushalappa ◽  
...  

2011 ◽  
Vol 59 (10) ◽  
pp. 5516-5522 ◽  
Author(s):  
Giuseppina Negri ◽  
Erica Weinstein Teixeira ◽  
Maria Luisa Teles Marques Florêncio Alves ◽  
Augusta Carolina de Camargo Carmell Moreti ◽  
Ivani Pozar Otsuk ◽  
...  

2015 ◽  
Vol 58 (3) ◽  
pp. 156-163 ◽  
Author(s):  
Donah Mary Macoy ◽  
Woe-Yeon Kim ◽  
Sang Yeol Lee ◽  
Min Gab Kim

2014 ◽  
Vol 27 (10) ◽  
pp. 1159-1169 ◽  
Author(s):  
Laura Campos ◽  
Purificación Lisón ◽  
María Pilar López-Gresa ◽  
Ismael Rodrigo ◽  
Laura Zacarés ◽  
...  

Hydroxycinnamic acid amides (HCAA) are secondary metabolites involved in plant development and defense that have been widely reported throughout the plant kingdom. These phenolics show antioxidant, antiviral, antibacterial, and antifungal activities. Hydroxycinnamoyl-CoA:tyramine N-hydroxycinnamoyl transferase (THT) is the key enzyme in HCAA synthesis and is induced in response to pathogen infection, wounding, or elicitor treatments, preceding HCAA accumulation. We have engineered transgenic tomato plants overexpressing tomato THT. These plants displayed an enhanced THT gene expression in leaves as compared with wild type (WT) plants. Consequently, leaves of THT-overexpressing plants showed a higher constitutive accumulation of the amide coumaroyltyramine (CT). Similar results were found in flowers and fruits. Moreover, feruloyltyramine (FT) also accumulated in these tissues, being present at higher levels in transgenic plants. Accumulation of CT, FT and octopamine, and noradrenaline HCAA in response to Pseudomonas syringae pv. tomato infection was higher in transgenic plants than in the WT plants. Transgenic plants showed an enhanced resistance to the bacterial infection. In addition, this HCAA accumulation was accompanied by an increase in salicylic acid levels and pathogenesis-related gene induction. Taken together, these results suggest that HCAA may play an important role in the defense of tomato plants against P. syringae infection.


2009 ◽  
Vol 64 (3-4) ◽  
pp. 176-178 ◽  
Author(s):  
Ivanka Stankova ◽  
Maya Spasova

Three hydroxycinnamic acid derivatives conjugated with glycine-containing oxazole were synthesized. The prepared compounds were tested for their antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH・) test. Among the tested hydroxycinnamic acid amides the highest DPPH scavenging activity has been found for the sinapic acid amide.


2015 ◽  
Vol 133 ◽  
pp. 57-64 ◽  
Author(s):  
Desiree Bailey ◽  
Brian P. Kirby ◽  
Jeffrey Atkinson ◽  
Solomon Fixon-Owoo ◽  
Martin C. Henman ◽  
...  

2018 ◽  
Vol 21 (0) ◽  
Author(s):  
Giuseppina Negri ◽  
Lidia Maria Ruv Carelli Barreto ◽  
Fábia Lugli Sper ◽  
Claudemir de Carvalho ◽  
Maria das Graças Ribeiro Campos

Abstract An Apis mellifera bee pollen sample from Bahia state in Brazil was studied to evaluate its botanical origin and phytochemical composition. The bee pollen sample was collected in the municipality of Canavieiras, in an area with a very high predominance of Cocos nucifera L (Aracaceae), which was identified as the major taxon (99%), thus being the possible botanical origin of this pollen. The main constituents found in the non-polar extract analysed by GC-EI-MS were saturated fatty acids and long chain esters, together with phytosterols such as ergosta-5,24(28)-dien-3-ol, campesterol and sitosterol, detected in smaller quantities. Flavonoid glycosides, as well as hydroxycinnamic acid amide derivatives were detected in the polar extract analysed by HPLC-ESI-MS/MS. The presence of flavonoid glycosides, hydroxycinnamic acid amide derivatives, fatty acids and phytosterols have been reported in many bee pollen taxa. To the best of the authors’ knowledge, this is the first study of the chemical composition of bee pollen from C. nucifera , which is cultivated for its coconut fruit.


2020 ◽  
Vol 11 ◽  
Author(s):  
Benjamin J. Knollenberg ◽  
Guo-Xing Li ◽  
Joshua D. Lambert ◽  
Siela N. Maximova ◽  
Mark J. Guiltinan

The hydroxycinnamic acid amides (HCAAs) are a diverse group of plant-specialized phenylpropanoid metabolites distributed widely in the plant kingdom and are known to be involved in tolerance to abiotic and biotic stress. The HCAA clovamide is reported in a small number of distantly related species. To explore the contribution of specialized metabolites to disease resistance in cacao (Theobroma cacao L., chocolate tree), we performed untargeted metabolomics using liquid chromatography – tandem mass spectrometry (LC-MS/MS) and compared the basal metabolite profiles in leaves of two cacao genotypes with contrasting levels of susceptibility to Phytophthora spp. Leaves of the tolerant genotype ‘Scavina 6’ (‘Sca6’) were found to accumulate dramatically higher levels of clovamide and several other HCAAs compared to the susceptible ‘Imperial College Selection 1’ (‘ICS1’). Clovamide was the most abundant metabolite in ‘Sca6’ leaf extracts based on MS signal, and was up to 58-fold higher in ‘Sca6’ than in ‘ICS1’. In vitro assays demonstrated that clovamide inhibits growth of three pathogens of cacao in the genus Phytophthora, is a substrate for cacao polyphenol oxidase, and is a contributor to enzymatic browning. Furthermore, clovamide inhibited proteinase and pectinase in vitro, activities associated with defense in plant-pathogen interactions. Fruit epidermal peels from both genotypes contained substantial amounts of clovamide, but two sulfated HCAAs were present at high abundance exclusively in ‘Sca6’ suggesting a potential functional role of these compounds. The potential to breed cacao with increased HCAAs for improved agricultural performance is discussed.


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