Cytotoxic Yohimbine‐Type Alkaloids from the Leaves of Rauvolfia vomitoria

2020 ◽  
Vol 17 (12) ◽  
Author(s):  
Guanqun Zhan ◽  
Rongkun Miao ◽  
Fuxin Zhang ◽  
Xingbin Wang ◽  
Xinxin Zhang ◽  
...  
Keyword(s):  
Rauvolfia Vomitoria

Two new alkaloids from Rauvolfia vomitoria

Planta Medica ◽  
2015 ◽  
Vol 81 (05) ◽  
Author(s):  
S Liang ◽  
Z Ali ◽  
IA Khan
Keyword(s):  
Rauvolfia Vomitoria

Phenolic constituents and inhibitory effects of the leaf of Rauvolfia vomitoria Afzel on free radicals, cholinergic and monoaminergic enzymes in rat’s brain in vitro

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Olubukola H. Oyeniran ◽  
Adedayo O. Ademiluyi ◽  
Ganiyu Oboh
Keyword(s):  
Lipid Peroxidation ◽  
Free Radicals ◽  
Methanolic Extract ◽  
Array Detector ◽  
Oh Radicals ◽  
Inhibitory Effects ◽  
Methanolic Extracts ◽  
Phenolic Constituents ◽  
Rauvolfia Vomitoria

AbstractObjectivesRauvolfia vomitoria is a medicinal plant used traditionally in Africa in the management of several human diseases including psychosis. However, there is inadequate scientific information on the potency of the phenolic constituents of R. vomitoria leaf in the management of neurodegeneration. Therefore, this study characterized the phenolic constituents and investigated the effects of aqueous and methanolic extracts of R. vomitoria leaf on free radicals, Fe2+-induced lipid peroxidation, and critical enzymes linked to neurodegeneration in rat’s brain in vitro.MethodsThe polyphenols were evaluated by characterizing phenolic constituents using high-performance liquid chromatography coupled with diode array detector (HPLC-DAD). The antioxidant properties were assessed through the extracts ability to reduce Fe3+ to Fe2+; inhibit ABTS, DPPH, and OH radicals and Fe2+-induced lipid peroxidation. The effects of the extracts on AChE and MAO were also evaluated.ResultsThe phenolic characterization of R. vomitoria leaf revealed that there were more flavonoids present. Both aqueous and methanolic extracts of R. vomitoria leaf had inhibitory effects with the methanolic extract having higher significant (p≤0.05) free radicals scavenging ability coupled with inhibition of monoamine oxidases. However, there was no significant (p≤0.05) difference obtained in the inhibition of lipid peroxidation and cholinesterases.ConclusionThis study suggests that the rich phenolic constituents of R. vomitoria leaf might contribute to the observed antioxidative and neuroprotective effects. The methanolic extract was more potent than the aqueous extract; therefore, extraction of R. vomitoria leaf with methanol could offer better health-promoting effects in neurodegenerative condition.

Rauvomines A and B, Two Monoterpenoid Indole Alkaloids from Rauvolfia vomitoria

2017 ◽  
Vol 19 (15) ◽  
pp. 3998-4001 ◽  
Author(s):  
Jun Zeng ◽  
Dong-Bo Zhang ◽  
Pan-Pan Zhou ◽  
Qi-Li Zhang ◽  
Lei Zhao ◽  
...  
Keyword(s):  
Indole Alkaloids ◽  
Monoterpenoid Indole Alkaloids ◽  
Rauvolfia Vomitoria

In vivo effects of Rauvolfia vomitoria ( Apocynaceae ) ethanolic extract on sexual performance and reproductive activity in male rats

Andrologia ◽  
2019 ◽  
Vol 52 (1) ◽  
Author(s):  
Brice Landry Koloko ◽  
Ijaz Bushra ◽  
Modeste Wankeu‐Nya ◽  
Marie Ide Ngaha Njila ◽  
Hubert Kenmogne ◽  
...  
Keyword(s):  
Ethanolic Extract ◽  
Reproductive Activity ◽  
Male Rats ◽  
Sexual Performance ◽  
In Vivo Effects ◽  
Rauvolfia Vomitoria

Antimycobacterial, antioxidant activity and toxicity of extracts from the roots of <i>Rauvolfia vomitoria</i> and <i>R. caffra</i>

Spatula DD ◽  
2011 ◽  
Vol 1 (2) ◽  
pp. 73 ◽  
Author(s):  
Paul Erasto ◽  
Zakaria Mbwambo ◽  
Ramadhani Nondo ◽  
Namrita Lall
Keyword(s):  
Antioxidant Activity ◽  
Rauvolfia Vomitoria
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